Testicular Adrenal Rest Tumor in 11-Beta-Hydroxylase Deficiency Driven Congenital Adrenal Hyperplasia

Mehmet Kaynar,Mehmet Giray Sönmez,Yaşar Ünlü,Tuna Karatağ,Erdem Tekinarslan,Alpay Sümer 대한비뇨의학회 2014 Investigative and Clinical Urology Vol.55 No.4

Testicular adrenal rest tumors (TART) occur often as asymptomatic nodules in corticotropin-dependent lesions aberrant adrenal tissue in congenital adrenal hyperplasia(CAH) patients. The present manuscript is about an unusual case of a 16-year-old CAHpatient due to 11β-hydroxylase deficiency. He underwent testicle biopsy because of testicletumor suspicion and diagnosed with TART.

Unilateral Posterior Surgery for Severe Osteoporotic Vertebrae Fractures’ Sequelae in Geriatric Population: Minimum 5-Year Results of 109 Patients

Tuna Pehlivanoglu,Yigit Erdag,Ismail Oltulu,Umut Dogu Akturk,Emre Korkmaz,Kerem Yildirim,Ender Sarioglu,Kerem Gun,Ender Ofluoglu,Mehmet Aydogan 대한척추신경외과학회 2021 Neurospine Vol.18 No.2

Objective: This study aimed to evaluate the efficacy and safety of modified posterior vertebral column resection (PVCR) combined with anterior column restoration in elderly patients presenting with thoracic or thoracolumbar osteoporotic fractures with spinal cord compression and severe pain. Methods: One hundred nine patients with one level thoracolumbar osteoporotic fracture and at least 5 years of follow-up were included. They underwent posterior instrumentation performed with polymethymetachrylate augmented pedicle screws. A modified PVCR (unilateral costotransversectomy+hemilaminectomy) combined with the insertion of an expandable titanium cage for anterior column restoration was undertaken. Patients were evaluated clinically and radiographically. Results: Patients had a mean age of 74.1 and a follow-up duration of 92.3 months. Mean duration of operations, hospital stays, and mean loss of blood were 172.3 minutes, 4.3 days, and 205.4 mL. All of the patients were mobilized immediately after surgery. The mean preoperative local kyphosis angle improved from 39.3° to 4.7° at the last follow-up (p=0.003). Patients preoperative mean visual analogue score, Japanese Orthopaedic Association, and Oswestry Disability Index scores improved from 7.7/8.6/76.3 to 1.6/26.1/17.4 (p<0.001 for all), respectively. The average 36-item Short-Form survey physical component summary/mental component summary scores at the last follow-up were 55.1/56.8. A dural tear was detected intraoperatively in 1 patient and repaired immediately. Conclusion: Subtotal PVCR combined with the insertion of an expandable titanium cage was detected as a safe and effective method for osteoporotic vertebrae fractures’ sequelae in the older population involving spinal cord compression by enabling the decompression of the spinal canal and reconstruction of the resected segment, resulting in significant improvement in clinical and radiographic outcomes.

The use of infrared thermography to detect the stages of estrus cycle and ovulation time in anatolian shepherd dogs

( Kemal Tuna Olgac ),( Ergun Akcay ),( Beste Cil ),( Burak Mehmet Ucar ),( Ali Daskın ) 한국축산학회(구 한국동물자원과학회) 2017 한국축산학회지 Vol.59 No.10

Background: The aim of the study is to evaluate the effectiveness of thermographic monitoring, using the temperature changes of perianal and perivulvar areas for the determination of estrus in Anatolian Shepherd bitches. Fifteen bitches were used in the study. Blood and vaginal smear samples were collected and thermographic monitoring of perianal and perivulvar areas were carried out starting from proestrus to early diestrus. Also, external signs of estrus were investigated. Smear samples were evaluated by light microscopy after Diff-Quik staining method and superficial and keratinized superficial cells were determined as percentage (S + KS%). Progesterone and luteinizing hormone measurements were done by radioimmunoassay. The difference in temperature between perianal and perivulvar areas was evaluated through thermographic images by FLIR ResearchIR Software. Results: According to the results obtained from the study, differences between progesterone and S + KS% were statistically significant (P < 0,05). Although temperature showed increase and decrease with progesterone and S + KS%, the differences were not important statistically (P > 0,05). Serum luteinizing hormone levels did not sign any difference (P > 0,05). Conclusions: As a result, thermographic monitoring alone is not enough for estrus detection in Anatolian Shepherd bitches. However, it can be used to assist the actual estrus detection technique in terms of providing some foreknowledge by evaluating the differences in temperature

Electrochemical synthesis and corrosion behaviour of poly (pyrrole-co-o-anisidine-co-o-toluidine)

Süleyman Yalçınkaya,Tunç Tüken,Birgül Yazıcı,Mehmet Erbil 한국물리학회 2010 Current Applied Physics Vol.10 No.3

In this study, a ter-polymer film of pyrrole, o-anisidine and o-toluidine has been electrochemically synthesized on low carbon steel. The synthesis solution was aqueous oxalic acid containing 2:1:1 monomer feed ratio between pyrrole, o-anisidine and o-toluidine, respectively. The characterization of synthesized ter-polymer film was realized with help of UV–Vis absorption, Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM) and differential scanning calorimetry (DSC) techniques. The stability of this ter-polymer film as a coating material has also been investigated on steel, in 3.5%NaCl solution. Under such severe conditions, the ter-polymer film was found to exhibit low permeability against water ingress. It was able to exhibit protective coating behavior on steel, even after 72 h exposure time. The DSC results revealed that the ter-polymer film had better thermal stability with respect to single polypyrrole film. The synthesized ter-polymer film was completely different in aspect of morphology,stability and other structural properties when compared to single polypyrrole film. This highly stable and extremely thin (0.80 ㎛) film can find application for various purposes (anticorrosive, electrocatalytic,etc.), at where the stability of polypyrrole like films constitutes a drawback.

Monte Carlo analysis of LWR spent fuel transmutation in a fusion-fi ssion hybrid reactor system

Sümer S¸ ahi_n,Hacı Mehmet S¸ ahin,Güven Tunç 한국원자력학회 2018 Nuclear Engineering and Technology Vol.50 No.8

The aim of this paper is to determine neutronic performances of the light water reactor (LWR) spent fuelmixed with fertile thorium fuel in a FFHR. Time dependent three dimensional calculations for majortechnical data, such as blanket energy multiplication, tritium breeding ratio, cumulative fissile fuelenrichment and burnup have been performed by using Monte Carlo Neutron-Particle Transport codeMCNP5 1.4, coupled with a novel interface code MCNPAS, which is developed by our research group. Aself-sustaining tritium breeding ratio (TBR>1.05) has been kept throughout the calculations. The studyhas shown that the fissile fuel quality will be improved in the course of the transmutation of the LWRspent in the FFHR. The latter has gained the reusable fuel enrichment level conventional LWRs betweenone and two years. Furthermore, LWR spent fuel - thorium mixture provides higher burn-up values thanin light water reactors.

Factors associated with surgical morbidity of primary debulking in epithelial ovarian cancer

( Emre Gunakan ),( Yusuf Aytac Tohma ),( Mehmet Tunc ),( Huseyin Akıllı ),( Hanifi Şahin ),( Ali Ayhan ) 대한산부인과학회 2020 Obstetrics & Gynecology Science Vol.63 No.1

Objective Epithelial ovarian cancer (EOC) requires an aggressive surgical approach. The important part of literature on ovarian cancer surgery emphasize residual tumor and survival analyses. Morbidity issue keeps in background. Therefore, we aimed to report on morbidity of cytoreductive surgery for EOC in this study. Methods EOC patients who underwent primary debulking were evaluated. Intraoperative and postoperative complications that occurred within 30 days after the surgery and factors that affect morbidity were considered. Results The study involved 359 patients. Forty-six intraoperative complications occurred in 42 (11.6%) patients. Advanced stage and cancer antigen level of 125 were independently and significantly associated with operative complications (hazard ratio [HR], 1.66; 95% confidence interval [CI], 1.01-2,73; P=0.044, and HR, 1.47; 95% CI, 1.05-2.06; P=0.025, respectively). The need for intensive care unit admission was significantly higher in patients with intraoperative complications (28.6% vs. 8.8%, P=0.001). Intraoperative and postoperative complication rates were significantly higher in extended surgery than in standard surgery (18.9%vs. 8.5%, P=0.005 and 38.7% vs. 10.9%, P<0.001, respectively). Intraoperative and postoperative transfusion need, hospital stay duration, and chemotherapy start day were also significantly higher in extended surgery than in standard surgery. Hundred postoperative complications occurred in 70 patients. Age, extended surgery, presence of ascites, and presence of operative complications were independently and significantly associated with postoperative complications. Conclusion Morbidity of extensive surgical approach should be kept in mind in ovarian cancer surgery aimed at leaving no residual tumor. Patient-based management with an appropriate preoperative evaluation may avoid morbidity of extended/extensive surgical approaches.

Detection of progressive and regressive phase and LINE-1 retrotransposon in transfected dogs with transmissible venereal tumor during chemotherapy

Sevil Atalay Vural,Rifki Haziroglu,Mehmet R. Vural,Ibrahim M. Polat,Arda S. Tunc 대한수의학회 2018 Journal of Veterinary Science Vol.19 No.5

Canine transmissible venereal tumor (CTVT) is a tumor that commonly occurs in genital and extragenital sites of both genders. Long interspersed nuclear elements (LINE-1) retrotransposon has a pivotal role in allogenic transfection among uncontrolled dog populations. This study aimed to perform pathomorphological, immunohistochemical, and in situ polymerase chain reaction (PCR) evaluation of CTVT (n = 18) in transfected dogs during chemotherapy. Immunohistochemically, tumor phases were investigated by using specific markers (CD3, CD4, CD8, CD79, and transforming growth factor beta [TGF-b]), and investigated an amplified specific sequence of TVT LINE-1 retrotransposon by in situ PCR. Polyhedral-shaped neoplastic cells that had large, round, hypo/hyperchromatic nuclei and eosinophilic cytoplasm were detected. All marker results were positive, especially in the early weeks of recovery. CD4 and TGF-b markers were conspicuously positive at the initial stage. In situ PCR LINE-1 sequence was initially positive in only four cases. It is believed that the CD and TGF-b markers provide phase identification at tumor initiation and during chemotherapy. It is thought that presence of T and B lymphocytes, which have roles in cellular and humoral immunity, is needed so that regression of the tumor is possible.

MMP2 Gene-735 C/T and MMP9 gene -1562 C/T Polymorphisms in JAK2V617F Positive Myeloproliferative Disorders

Sag, Sebnem Ozemri,Gorukmez, Ozlem,Ture, Mehmet,Gorukmez, Orhan,Topak, Ali,Sahinturk, Serdar,Ocakoglu, Gokhan,Gulten, Tuna,Ali, Ridvan,Yakut, Tahsin Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.2

Background: Myeloproliferative disorders (MPDs) are clonal hematologic malignancies originating at the level of the pluripotent hematopoietic stem cell. Matrix metalloproteases (MMPs) are proteolytic enzymes that contribute to all stages of malignancy progression. Genetic variants in the MMP genes may influence the biological function of these enzymes and change their role in carcinogenesis and progression. To our knowledge, this is the first investigation of associations between the -735 C/T and -1562 C/T polymorphisms in the MMP2 and MMP9 genes, respectively, and the risk of essential thrombocytosis (ET), and polycythemia vera (PV). Materials and Methods: The case-control study included JAK2V617F mutation positive 102 ET and PV patients and 111 controls. Polymorphisms were determined by using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and electrophoresis. Results: No statistically significant differences were detected between patient (ET+PV) and control groups regarding genotype distribution for MMP2 gene-735 C/T and MMP9 gene -1562 C/T polymorphisms and C/T allele frequency (p>0.050). Statistically borderline significance was observed between PV and control groups regarding genotype distribution for the MMP9 gene -1562 C/T polymorphism (p=0.050, OR=2.26, 95%Cl=0.99-5.16). Conclusions: Consequently this study supported that CC genotype of MMP9 gene -1562 C/T polymorphism may be related with PV even if with borderline significance.