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Magnetic Resonance Myocardial Feature Tracking in Transfusion-Dependent Myelodysplastic Syndrome
Marta Alonso-Fernandez-Gatta,Ana Martin-Garcia,Maria Diez-Campelo,Agustin C. Martin-Garcia,Manuel Barreiro-Pérez,Félix Lopez-Cadenas,Elena Diaz-Pelaez,Pedro L. Sanchez 한국심초음파학회 2021 Journal of Cardiovascular Imaging (J Cardiovasc Im Vol.29 No.4
BACKGROUND: Myocardial deformation with echocardiography allows early detection of systolic dysfunction and is related to myocardial iron overload (MIO) determined by T2* in hereditary anemias under transfusion support. Our aim was to analyze the diagnostic and prognostic usefulness of magnetic resonance feature tracking (MR-FT) myocardial strain in low-risk myelodysplastic syndromes (LR-MDS) patients. METHODS: Prospective study in transfusion-dependent LR-MDS patients and healthy controls who underwent a cardiac MR-FT. We analyzed the relationships between strain MR-FT and iron overload parameters and its prognostic impact in cardiovascular events and/or death. RESULTS: Thirty-one patients and thirteen controls were included. MIO (T2* < 20 ms) was detected in 9.7% of patients. Left ventricular global longitudinal strain (LV-GLS) by MR-FT was pathological (> −19.3%) in 32.3% of patients. Less negative strain values correlated with lower T2* (R = −0.37, p = 0.033) and native myocardial T1 (R = −0.39, p = 0.031) times. LV-GLS by MR-FT was significantly associated with higher incidence of the combined cardiovascular events and/or all-cause death (p = 0.047), with a cut-off value of −17.7% for predicting them (63% sensitivity and 81% specificity, area under the curve = 0.69). After adjusting analysis including demographic, biomarkers and imaging variables, a higher LV-GLS value by MR-FT remained as predictor of combined event in transfusion-dependent LR-MDS patients (hazard ratio, 0.4; confidence interval, 0.15–0.98; p = 0.045). CONCLUSIONS: Longitudinal myocardial strain by MR-FT in LR-MDS patients is associated to MIO and correlates with adverse events in the follow-up, what could serve as a prognostic tool.
Endoscopic ultrasound-guided gastroenterostomy (gastroenteric anastomosis)
Joel Fernandez de Oliveira,Matheus Cavalcante Franco,Gustavo Rodela,Fauze Maluf-Filho,Bruno Costa Martins 소화기인터벤션의학회 2022 International journal of gastrointestinal interven Vol.11 No.3
Endoscopic ultrasound-guided gastroenterostomy (EUS-GE) has emerged as a promising minimally invasive technique for patients with gastric outlet obstruction (GOO), regardless of whether a benign or malignant condition impedes gastric emptying. EUS-GE involves creating a bypass from the stomach to the small bowel distally to the obstruction, which is similar to the surgical gastroenteric anastomosis. In fact, EUS-GE has been reported to have longer stent patency in patients with malignant GOO than conventional self-expandable metal stents deployed across a malignant obstruction. Although surgical treatment is still considered the gold-standard treatment for patients with malignant GOO, the results of recent studies have shown not only similar rates of technical and clinical success with EUS-GE, but also lower rates of adverse events. In this review, we aimed to appraise the current status of EUS-GE, describe the multiple techniques to perform this procedure, compare the outcomes of EUS-GE with those of other therapeutic modalities, and discuss the related adverse events and the future perspectives of EUS-GE.
Endoscopic ultrasound-guided gastroenterostomy (gastroenteric anastomosis)
Joel Fernandez de Oliveira,Matheus Cavalcante Franco,Gustavo Rodela,Fauze Maluf-Filho,Bruno Costa Martins 소화기인터벤션의학회 2022 Gastrointestinal Intervention Vol.11 No.3
Endoscopic ultrasound-guided gastroenterostomy (EUS-GE) has emerged as a promising minimally invasive technique for patients with gastric outlet obstruction (GOO), regardless of whether a benign or malignant condition impedes gastric emptying. EUS-GE involves creating a bypass from the stomach to the small bowel distally to the obstruction, which is similar to the surgical gastroenteric anastomosis. In fact, EUS-GE has been reported to have longer stent patency in patients with malignant GOO than conventional self-expandable metal stents deployed across a malignant obstruction. Although surgical treatment is still considered the gold-standard treatment for patients with malignant GOO, the results of recent studies have shown not only similar rates of technical and clinical success with EUS-GE, but also lower rates of adverse events. In this review, we aimed to appraise the current status of EUS-GE, describe the multiple techniques to perform this procedure, compare the outcomes of EUS-GE with those of other therapeutic modalities, and discuss the related adverse events and the future perspectives of EUS-GE.
Structural Performance of RC Beams containing Tension-Only Nodes
Manuel Alejandro Fernandez-Rui,Luisa Marı´a Gil-Martin,Enrique Hernandez-Montes 한국콘크리트학회 2018 International Journal of Concrete Structures and M Vol.12 No.1
Strut and Tie (S&T) models are used for the design of what are known as ‘‘discontinuity regions’’ in reinforced concrete (RC) structures. Building codes such as ACI-318 and Eurocode 2 do not give information on the nodes that only connect ties in S&T models (called TTT or tension-only nodes). However, their use is not explicitly prohibited in the design of RC structures. In this work, a comparison between solutions which have been designed both considering and not considering TTT nodes is evaluated. Four RC beams (designed with and without TTT nodes) were subjected to three-point bending. Experimental results show that TTT nodes are a good design solution for special cases of discontinuity regions in RC structures. However, the experimental campaign has proven that this type of node is more vulnerable to errors during construction than solutions designed without TTT nodes.
Bragg reflection of terahertz waves in plasmonic crystals
Lee, Eui Su,Kang, D. H.,Fernandez-Dominguez, A. I.,Garcia-Vidal, F. J.,Martin-Moreno, L.,Kim, D. S.,Jeon, Tae-In The Optical Society 2009 Optics express Vol.17 No.11
<P>We present experimental and theoretical studies on terahertz surface plasmon (TSP) propagation on slit and rectangular aperture arrays in an aluminum sheet. Terahertz waves are coupled onto the plasmonic structures via a parallel plate waveguide. Long-lasting oscillations are observed in the temporal pulse shape after propagating through the periodic structure, whose Fourier transformation into the frequency domain results in Bragg-resonance spectral features. We show that the interference between the incident wave and the radiation reflected from both the aperture array and the waveguide block is responsible for this Bragg-resonance behavior. The reflection coefficient for a single slit is deduced to be 0.017 +/- 0.002.</P>
( Pedro Reales Figueroa ),( Yasser Hessein Abdou ),( Maria Martin Toledano Lucas ),( Ibrahim Hamad ),( Adrian Ruiz Fernandez ),( Juan Velasco Franco ),( Marta Salas Cabanas ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Aims: Current guidelines recommend the use of a basal-bolus insulin regimen in hospitalized patients with hyperglycemia or type 2 DM. In addition a simple strategy facilitating the reconciliation of medication on discharge can improve glycemic control post-discharge. With our study we want to test whether this better glycemic control is maintained over time. Methods: Our study is a prospective and observational study during routine clinical practice. It has been held in an Department of Internal Medicine during hospitalization, with follow-up visit at 3 months after discharge and followed up for 3 years. Study patients (30) were treated with a regimen of basal-bolus insulin during hospitalization and an adjustment of their antidiabetic treatment at discharge. As a control group we included patients(30) hospitalized with similar characteristics, treated with other regimen of insulin or oral antidiabetic agents and to which either no treatment adjustment is recommended at discharge. A follow-up to all patients at 3 months after discharge and again after 3 years I realize. Results: Comparing the study group with the control group we found no differences in baseline HbA1c (8,52%±0,81 vs 8,61%±0.72; p:0,652), age (67,7±3,76 vs 67,8±3,71; p:0,86), sex (16 male vs 17 mal) and BMI (30,33±1,62 Kg/m2 vs 30,41±1,63 Kg/m2). Compared with baseline, the HbA1c at 3 months after discharge is lowe r(7,51%±0.81 vs 8,52%±0,81;p:0,001) and 3 years after discharge also remains lower(7,81%±0,81vs8,52%±0,81; p:0,013). Compared with control subjects, patients included in study have lower HbA1c at 3 months after discharge (7,51%±0,81 vs 8,71% ± 0,81:p:0,004) and lower HbA1c at 3 years after discharge (7,81%±0,81 vs 8,91%±0,81; p:0,002). Conclusion: This study confi rm that protocols to manage hyperglycemia with basal-bolus insulin regimens are also feasible and effective in routine clinical practice, and demonstrate that a simple strategy facilitating the reconciliation of medication on discharge can improve glycemic control post-discharge, that remains after 3 years or follow.
C. Garcia‑Cabezon,M. A. Castro‑Sastre,A. I. Fernandez‑Abia,M. L. Rodriguez‑Mendez,F. Martin‑Pedrosa 대한금속·재료학회 2022 METALS AND MATERIALS International Vol.28 No.11
The 17–4 Precipitation Hardening Stainless Steel (PH SS) manufactured by Selective Laser Melting (SLM) has wide applicationperspectives, but they are limited due to defects and anisotropy. The selection of the appropriate process variablesplays a fundamental part in the microstructure and in the determination of the final mechanical and corrosion properties. The main purpose of this study is to analyze the corrosion behavior, hardness and microstructure of 17–4 PH SS manufacturedby SLM in comparison to the commercial counterparts. The anisotropic behavior was investigated by analyzing themicrostructure–hardness and corrosion interrelationship, both in the surface of the construction platform and in the growthdirection of the element. The corrosion behavior of the SLM 17–4PH SS in its natural state was investigated in relation tothat of the 17–4 PH SS heat treated in a 0.1 M NaCl + 0.5 M H2SO4solution, using three electrochemical techniques. Theresults confirmed that the corrosion resistance of SLM 17–4 PH SS was considerably better than that of the forging, evenafter 60 days of immersion in the test solution. This was attributed to the absence of important manufacturing defects, tothe fine microstructure with an important amount of austenite produced by SLM, and to a small amount of non-metallicinclusions precipitated as a result of the fast cooling and the high speed of solidification associated with the SLM process.
Neoadjuvant therapy impact in early pancreatic cancer: “bioborderline” vs. “non-bioborderline”
Alvaro Gregorio Morales Taboad,Pablo Lozano Lominchar,Maria Fernandez Martinez,Pilar Garcia-Alfonso,Andres Munoz Martin,Jose Manuel Asencio 한국간담췌외과학회 2022 Annals of hepato-biliary-pancreatic surgery Vol.26 No.4
Characterization of the New n_TOF Neutron Beam: Fluence, Profile and Resolution
C. Guerrero,V. Becares,D. Cano-Ott,M. Fernandez-Ordonez,E. Gonzalez-Romero,F. Martin-Fuertes,T. Martinez,E. Mendoza,G. Pina,J. Quinones,V. Vlachoudis,M. Calviani,S. Andriamonje,M. Brugger,F. Cerutti,E 한국물리학회 2011 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.59 No.23
After a halt of four years, the n_TOF spallation neutron facility at CERN has resumed operation in November 2008 with a new spallation target characterized by an improved safety and engineering design, resulting in a more robust overall performance and efficient cooling. The first measurement during the 2009 run has aimed at the full characterization of the neutron beam. Several detectors, such as calibrated fission chambers, the n\textunderscore TOF Silicon Monitor, a MicroMegas detector with ^(10)B and ^(235)U samples, as well as liquid and solid scintillators have been used in order to characterize the properties of the neutron fluence. The spatial profile of the beam has been studied with a specially designed "X-Y" MicroMegas which provided a 2D image of the beam as a function of neutron energy. Both properties have been compared with simulations performed with the FLUKA code. The characterization of the resolution function is based on results from simulations which have been verified by the study of narrow capture resonances of ^(56)Fe, which were measured as part of a new campaign of (n, γ) measurements on Fe and Ni isotopes.
Alvarez-Arenal, Angel,Gonzalez-Gonzalez, Ignacio,deLlanos-Lanchares, Hector,Martin-Fernandez, Elena,Brizuela-Velasco, Aritza,Ellacuria-Echebarria, Joseba The Korean Academy of Prosthodonitics 2017 The Journal of Advanced Prosthodontics Vol.9 No.5
PURPOSE. The aim of this study is to evaluate and compare the stress distribution in Locator attachments in mandibular two-implant overdentures according to implant locations and different loading conditions. MATERIALS AND METHODS. Four three-dimensional finite element models were created, simulating two osseointegrated implants in the mandible to support two Locator attachments and an overdenture. The models simulated an overdenture with implants located in the position of the level of lateral incisors, canines, second premolars, and crossed implant. A 150 N vertical unilateral and bilateral load was applied at different locations and 40 N was also applied when combined with anterior load at the midline. Data for von Mises stresses in the abutment (matrix) of the attachment and the plastic insert (patrix) of the attachment were produced numerically, color-coded, and compared between the models for attachments and loading conditions. RESULTS. Regardless of the load, the greatest stress values were recorded in the overdenture attachments with implants at lateral incisor locations. In all models and load conditions, the attachment abutment (matrix) withstood a much greater stress than the insert plastic (patrix). Regardless of the model, when a unilateral load was applied, the load side Locator attachments recorded a much higher stress compared to the contralateral side. However, with load bilateral posterior alone or combined at midline load, the stress distribution was more symmetrical. The stress is distributed primarily in the occlusal and lateral surface of the insert plastic patrix and threadless area of the abutment (matrix). CONCLUSION. The overdenture model with lateral incisor level implants is the worst design in terms of biomechanical environment for the attachment components. The bilateral load in general favors a more uniform stress distribution in both attachments compared to a much greater stress registered with unilateral load in the load side attachments. Regardless of the implant positions and the occlusal load application site, the stress transferred to the insert plastic is much lower than that registered in the abutment.