Clouding phenomenon of amphiphilic drug promazine hydrochloride solutions: Influence of pharmaceutical excipients

Malik Abdul Rub,Naved Azum,Dileep Kumar,Farah Khan,Abdullah M. Asiri 한국공업화학회 2015 Journal of Industrial and Engineering Chemistry Vol.21 No.1

Various additives viz. hydrotropes, bile salts, fatty acid and cyclodextrin effect on the cloudpoint (CP) behavior of amphiphilic drug promazine hydrochloride (PMZ) in 1 mmol dm 3 14-4-14 + 10 mmol dm 3 sodium phosphate (SP) buffer solutions have been investigated in the present study. These various additives are usually used as pharmaceutical excipients. The additives like anionichydrotropes, bile salts and fatty acid salts increase the CP of PMZ, when added in low concentrations,whereas at high concentration, decrease it. Cationic and nonionic hydrotropes increase the CP of PMZsolutions at all concentration. Cyclodextrin behave like simple sugar is found to decrease the CP of thedrug solutions at all concentrations. Gemini surfactant (14-4-14) has been found a better surfactant thatcan prevent clouding under physiological condition. It can thus be used as a drug-carrier system thatincreases the storage stability. The thermodynamic parameters are also evaluated: where DGocis foundto be negative and DHoc and TDSocvalues are negative as well as positive depending upon type and natureof additive.

Investigation of micellar and phase separation phenomenon of phenothiazine drug promazine hydrochloride with anionic hydrotropes

Malik Abdul Rub,Abdullah M. Asiri,Naved Azum,Kabir-ud-Din 한국공업화학회 2014 Journal of Industrial and Engineering Chemistry Vol.20 No.4

The purpose of the present study was to determine the influence of various anionic hydrotropes on the self-aggregation and phase behavior of amphiphilic drug promazine hydrochloride (PMZ) and to search for means which reduce/increase the values of critical micelle concentration (cmc) and boost/suppress the cloud point (CP), respectively, used in pharmaceutical formulations. By using regular solution theory (RST) and Rosen’s model various micellar and surface properties such as micellar composition, surface excess concentration (Gmax), interaction parameters (bm, bs) etc. have been determined. The solution micellar behaviors were also investigated using Motomura and Rodenas models for defense and comparison of results. Thermodynamic parameters were also evaluated and discussed.

Micellization behavior of mixtures of amphiphilic promazine hydrochloride and cationic aniline hydrochloride in aqueous and electrolyte solutions

Malik Abdul Rub,Naved Azum,Farah Khan,Abdullah G. Al-Sehemi,Abdullah M. Asiri 한국화학공학회 2015 Korean Journal of Chemical Engineering Vol.32 No.10

We studied the influence of cationic hydrotrope aniline hydrochloride on the micellization behavior of cationic amphiphilic phenothiazine drug promazine hydrochloride in the presence and absence of 50mmol kg−1 NaCl. The experimental critical micelle concentration (CMC) values came out to be lower than ideal CMC (CMCid) values, signifying attractive interactions between the two components in mixed micelles. NaCl further decreases the CMC of pure PMZ and aniline hydrochloride as well as their mixture due to screening of the electrostatic repulsion among the polar head groups. The bulk properties of solution were examined by using different theoretical models for justification and comparison of results. The micellar mole fraction of aniline hydrochloride (X1 Rub, X1 M, X1 Rod and X1 id) was evaluated by different proposed models, showing greater contribution of hydrotrope in mixed micelle. The negative values of interaction parameter (β) indicate synergistic interactions and negative values of β further decrease by the addition of salt in mixed systems. From the CMC values as a function of temperature, various thermodynamic properties have been evaluated and discussed in detail.

Amphiphilic antidepressant drug amitriptyline hydrochloride under the influence of ionic and nonionic hydrotropes; micellization and phase separation

Malik Abdul Rub,Abdullah M. Asiri,Naved Azum,Anish Khan,Aftab Aslam Parwaz Khan,Sher Bahadar Khan,Mohammed M. Rahman,Kabir-ud-Din 한국공업화학회 2013 Journal of Industrial and Engineering Chemistry Vol.19 No.6

Herein we report the micellization and cloud point of an amitriptyline hydrochloride (AMT) under the influence of cationic, anionic and nonionic hydrotropes. Anionic hydrotropes were employed to know the micellar and surface behaviors, besides studying the clouding behavior of AMT drug with cationic,anionic and nonionic hydrotropes. Tensiometric study has been performed and the properties studied include the critical micelle concentration (cmc), maximum surface excess at the air/water interface (Gmax), the minimum area per of amphiphilic molecule at air/water interface (Amin), and the different thermodynamic parameters, besides clouding phenomenon. Interaction parameters of micelles (bm) and monolayer (bs) indicate that drug-hydrotrope systems show better interaction at the interface than in micelles.

Biomedical features and therapeutic potential of rosmarinic acid

Saba Noor,Taj Mohammad,Malik Abdul Rub,Ali Raza,Naved Azum,Dharmendra Kumar Yadav,Md Imtaiyaz Hassan,Abdullah M. Asiri 대한약학회 2022 Archives of Pharmacal Research Vol.45 No.4

For decades, the use of secondary metabolitesof various herbs has been an attractive strategy in combatinghuman diseases. Rosmarinic acid (RA) is a bioactivephenolic compound commonly found in plants of Lamiaceaeand Boraginaceae families. RA is biosynthesizedusing amino acids tyrosine and phenylalanine via enzymecatalyzedreactions. However, the chemical synthesis of RAinvolves an esterifi cation reaction between caff eic acid and3,4-dihydroxy phenyl lactic acid contributing two phenolicrings to the structure of RA. Several studies have ascertainedmultiple therapeutic benefi ts of RA in various diseases,including cancer, diabetes, infl ammatory disorders, neurodegenerativedisorders, and liver diseases. Many previousscientifi c papers indicate that RA can be used as an antiplasmodic,anti-viral and anti-bacterial drug. In addition,due to its high anti-oxidant capacity, this natural polyphenolhas recently gained attention for its possible applicationas a nutraceutical compound in the food industry. Here we provide state-of-the-art, fl exible therapeutic potential andbiomedical features of RA, its implications and multipleuses. Along with various valuable applications in safeguardinghuman health, this review further summarizes thetherapeutic advantages of RA in various human diseases,including cancer, diabetes, neurodegenerative diseases. Furthermore,the challenges associated with the clinical applicabilityof RA have also been discussed.

Experimental and theoretical investigation of micellization behavior of sodium dodecyl sulfate with cetyltrimethylammonium bromide in aqueous/urea solution at various temperatures

Md. Anamul Hoque,Shamim Mahbub,Malik Abdul Rub,Shahed Rana,Mohammed Abdullah Khan 한국화학공학회 2018 Korean Journal of Chemical Engineering Vol.35 No.11

Mixed micelle formation behavior of cationic surfactant-cetyltrimethylammonium bromide (CTAB) and anionic surfactant sodium dodecyl sulfate (SDS) in aqueous as well as in urea medium from 303.15K to 323.15K at 5K interval was carried out by conductometric method. The differences between the experimental values of critical micelle concentrations (cmc) and ideal critical micelle concentrations (cmcid) illustrate the interaction between the amphiphiles studied. The values of micellar mole fraction (X1Rub (Rubingh), X1 M (Motomura), X1Rod (Rodenas) and X1 id (ideal) of surfactant CTAB determined by different proposed models and outcome indicate high involvement of CTAB in SDS-CTAB mixed micellization, which enhance by means of the augment of mole fraction of CTAB. The negative value of interaction parameter (  ) showed an attractive interaction involving CTAB and SDS. Activity coefficients were less than unity in all case, which also reveals the presence of interaction between CTAB & SDS. The negative G0 m values imply the spontaneous mixed micellization phenomenon. The attained values of H0 m were positive at inferior temperature, while negative at superior temperature. The negative H0 m values in urea (NH 2CONH2) medium illustrate exothermic micellization process. The magnitudes of S0 m were positive in almost all cases. The excess free energy of mixed micelle formation (Gex) was found to be negative, which indicates the stability of mixed micelle as compared to the individual’s components micelles.

Effect of low levels of hydrotropes on micellization of phenothiazine drug

Sulaiman Y. M. Alfaifi,Dileep Kumar,Malik Abdul Rub,Farah Khan,Naved Azum,Anish Khan,Abdullah M. Asiri,Hurija Džudžević-Čančar 한국화학공학회 2021 Korean Journal of Chemical Engineering Vol.38 No.2

Interactions within mixtures of the phenothiazine drug promethazine hydrochloride (PMH) and cationic hydrotropes ortho-toluidine hydrochloride (o-TDH) and para-toluidine hydrochloride (p-TDH) were investigated at different ratios and temperatures via conductometry to understand various physicochemical properties. Critical micelle concentration (cmc) was less than values of cmcid (cmc in ideal mixed system), indicating significant interaction among the studied constituents in solution mixtures. The cmc of pure PMH was also determined by measuring the surface tension for comparison. A variety of micellization thermodynamic parameters (Gibbs free energy [Gm 0 ], change in standard enthalpy [Hm 0 ], and change in entropy [Sm 0 ]) were computed using conductometry. The micellar mole fraction (X1 Rb, X1 Rod, and X1 id) of hydrotropes estimated by various theoretical models (Rubingh, Rodenas, and Motomura) was assessed, and the results showed a greater contribution of hydrotropes in mixed micelles along with their values increasing via an increase in mole fraction (1) of hydrotropes (o-TDH/p-TDH). Negative  values suggest extremely favorable attractive interaction/synergism, as declines occurred in the whole quantity of amphiphile used for the desired purpose, leading to a drop of expenditure along with ecological concern. Obtained activity coefficients (f1 and f2) were always beneath unity, meaning nonideality was found between PMH and o-TDH/p-TDH. Like the conductivity method, the UV-visible and FT-IR techniques also demonstrate the interaction between the PMH and o-TDH/p-TDH.

UV-Visible spectroscopic and DFT studies of the binding of ciprofloxacin hydrochloride antibiotic drug with metal ions at numerous temperatures

Mohammed Ashraf Uddin,Bupasha Hekim Sutonu,Malik Abdul Rub,Shamim Mahbub,Maha Moteb Alotaibi,Abdullah M. Asiri,Shahed Rana,Md. Anamul Hoque,Mahbub Kabir 한국화학공학회 2022 Korean Journal of Chemical Engineering Vol.39 No.3

Ciprofloxacin hydrochloride (CPFH) is a very common antibiotic drug for the treatment of different types of bacterial infections. The activity of the drug depends on the complexation of the employed drug with different metals present in the body. In the current investigation, the complexation behavior of CPFH drug with numerous metal ions was explored by means of UV-Visible spectroscopic and density functional theory (DFT) techniques at various temperatures. The binding constants (Kf) of CPFH+metal ions complexes were determined from the Benesi-Hildebrand equation. The Kf values experience an alteration with the nature of metal ions employed and the change of temperature. The binding of CPFH with alkali earth metals decreases with the increase of metal size and increases with the increase of temperature, while the opposite effect of temperature was observed for transition metals. The Gibbs free energy of binding (Go) for the complexation between CPFH and metal ions was negative in all cases, which reveals that the complexation phenomenon is spontaneous. The values of enthalpy and entropy connote the presence of both hydrophobic and electrostatic interactions. The complexation of CPFH was observed to be endothermic in the case of alkali earth metals while exothermic for transition metals. The intrinsic enthalpy gain (Ho, *) values signify the higher stability of metal-drug complexes. The compensation temperature (TC) values were found to be comparable to the biological systems. DFT studies show the formulation of 1 : 1 complexes with transition metals as well as the square planar geometry of the complexes. HOMO and LUMO analyses reveal that the stability of CPFH-Ni complexes is higher than that of CPFH-Co/CPFH-Zn complexes.

Mechanistic investigation of the oxidation of Cefuroxime by hexacyanoferrate(III) in alkaline conditions

Aftab Aslam Parwaz Khan,Abdullah M. Asiri,Anish Khan,Naved Azum,Malik Abdul Rub,Mohammed M. Rahman,Sher Bahadar Khan,K. S. Siddiqi,Khalid A. Alamry 한국공업화학회 2013 Journal of Industrial and Engineering Chemistry Vol.19 No.2

The reactions of Cefuroxime (CFA) by hexacyanoferrate (III) (HCF(III)) in alkaline medium at a constant ionic strength has been studied spectrophotometrically. It is a first order reaction, but fractional order in both CFA and alkali. Decrease in dielectric constant of the medium decreases the rate of reaction. The effect of added products and ionic strength has also been investigated. A mechanism involving free radicals is proposed. In a composite equilibrium step, CFA binds to HCF(III) to form a complex that subsequently decomposes to the products. The main two products were separated and identified by column chromatography, TLC and FT-IR. There is good agreement between the observed and calculated rate constants under different experimental conditions. The reaction was studied at different temperatures and activation parameters were computed with respect to the slow step of the proposed mechanism.

Applied poly(2-methoxy aniline) Sn(II)silicate carbon nanotubes composite: Synthesis, characterization, structure–property relationships and applications

Anish Khan,Aftab Aslam Parwaz Khan,Abdullah M. Asiri,Malik Abdul Rub,Naved Azum,Sher Bahadar Khan,Hadi M. Marwani 한국공업화학회 2014 Journal of Industrial and Engineering Chemistry Vol.20 No.4

A new class hybrid poly(2-methoxy aniline) Sn(II)silicate carbon nanotubes composite was synthesized by sol–gel method. The physico-chemical characterization was carried out by Scanning Electron micrograph, X-ray Diffraction, Fourier Transform Infrared, Ultraviolet–Visible Spectroscopy and simultaneous Thermo Gravimetric Analysis. The ion-exchange studies were also carried out to understand the ion-exchange capabilities. The dc electrical conductivity studies reviles its highly conducting nature in the range of 2–3-2 S cm-1. On the basis of distribution studies it was found highly selective for Hg2+. Due to selectivity of the composite, ion selective membrane was prepared and employed it as an indicator electrode in potentiometric titrations.