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RISS 인기검색어
- 검색키워드
- 저자 : Loo Han Chuan (검색결과 3 건)
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Creation of Consistent Burn Wounds: A Rat Model
Cai, Elijah Zhengyang,Ang, Chuan Han,Raju, Ashvin,Tan, Kong Bing,Hing, Eileen Chor Hoong,Loo, Yihua,Wong, Yong Chiat,Lee, Hanjing,Lim, Jane,Moochhala, Shabbir M.,Hauser, Charlotte A.E.,Lim, Thiam Chye Korean Society of Plastic and Reconstructive Surge 2014 Archives of Plastic Surgery Vol.41 No.4
Background Burn infliction techniques are poorly described in rat models. An accurate study can only be achieved with wounds that are uniform in size and depth. We describe a simple reproducible method for creating consistent burn wounds in rats. Methods Ten male Sprague-Dawley rats were anesthetized and dorsum shaved. A 100 g cylindrical stainless-steel rod (1 cm diameter) was heated to $100^{\circ}C$ in boiling water. Temperature was monitored using a thermocouple. We performed two consecutive toe-pinch tests on different limbs to assess the depth of sedation. Burn infliction was limited to the loin. The skin was pulled upwards, away from the underlying viscera, creating a flat surface. The rod rested on its own weight for 5, 10, and 20 seconds at three different sites on each rat. Wounds were evaluated for size, morphology and depth. Results Average wound size was $0.9957cm^2$ (standard deviation [SD] 0.1845) (n=30). Wounds created with duration of 5 seconds were pale, with an indistinct margin of erythema. Wounds of 10 and 20 seconds were well-defined, uniformly brown with a rim of erythema. Average depths of tissue damage were 1.30 mm (SD 0.424), 2.35 mm (SD 0.071), and 2.60 mm (SD 0.283) for duration of 5, 10, 20 seconds respectively. Burn duration of 5 seconds resulted in full-thickness damage. Burn duration of 10 seconds and 20 seconds resulted in full-thickness damage, involving subjacent skeletal muscle. Conclusions This is a simple reproducible method for creating burn wounds consistent in size and depth in a rat burn model.
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Creation of Consistent Burn Wounds: A Rat Model
Elijah Zhengyang Cai,Chuan Han Ang,Kong Bing Tan,Eileen Chor Hoong Hing,Yihua Loo,Yong Chiat Wong,Hanjing Lee,Jane LIM,Shabbir M Moochhala,Charlotte AE Hauser,Thiam Chye LIM,Ashvin Raju 대한성형외과학회 2014 Archives of Plastic Surgery Vol.41 No.4
Background: Burn infliction techniques are poorly described in rat models. An accurate studycan only be achieved with wounds that are uniform in size and depth. We describe a simplereproducible method for creating consistent burn wounds in rats. Methods: Ten male Sprague-Dawley rats were anesthetized and dorsum shaved. A 100 gcylindrical stainless-steel rod (1 cm diameter) was heated to 100°C in boiling water. Temperature was monitored using a thermocouple. We performed two consecutive toe-pinchtests on different limbs to assess the depth of sedation. Burn infliction was limited to theloin. The skin was pulled upwards, away from the underlying viscera, creating a flat surface. The rod rested on its own weight for 5, 10, and 20 seconds at three different sites on eachrat. Wounds were evaluated for size, morphology and depth. Results: Average wound size was 0.9957 cm2 (standard deviation [SD] 0.1845) (n=30). Wounds created with duration of 5 seconds were pale, with an indistinct margin of erythema. Wounds of 10 and 20 seconds were well-defined, uniformly brown with a rim of erythema. Average depths of tissue damage were 1.30 mm (SD 0.424), 2.35 mm (SD 0.071), and 2.60mm (SD 0.283) for duration of 5, 10, 20 seconds respectively. Burn duration of 5 secondsresulted in full-thickness damage. Burn duration of 10 seconds and 20 seconds resulted infull-thickness damage, involving subjacent skeletal muscle. Conclusions: This is a simple reproducible method for creating burn wounds consistent insize and depth in a rat burn model.
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Nyanti Larry Ellee,Chua Chia Zhen,Loo Han Chuan,Khor Cheng Zhi,Toh Emilia Sheau Yuin,Gill Rasvinder Singh,Chan Eng Tat,Tan Ker Yin,Rosli Taufiq,Rahim Muhammad Aklil Abd,Ibrahim Arfian,Huan Nai Chien,R 대한결핵및호흡기학회 2023 Tuberculosis and Respiratory Diseases Vol.86 No.4
Background: Attitudes towards smoking, lung cancer screening, and perceived risk of lung cancer have not been widely studied in Malaysia. The primary objective of this study was to describe the factors affecting the willingness of high-risk current smokers and ex-smokers to undergo low-dose computed tomography (LDCT) screening for lung cancer.Methods: A prospective, cross-sectional questionnaire study was conducted in current smokers or ex-smokers aged between 55 and 80 years at three hospitals in Kota Kinabalu, Sabah, Malaysia. The questionnaire recorded the following parameters: perceived lung cancer risk; Prostate Lung Colon Ovarian Cancer 2012 risk prediction model excluding race and ethnicity predictor (PLCOm2012norace); demographic characteristics; psychosocial characteristics; and attitudes towards lung cancer and lung cancer screening.Results: A vast majority of the 95 respondents (94.7%) indicated their willingness to undergo screening. Stigma of lung cancer, low levels of knowledge about lung cancer symptoms, concerns about financial constraints, and a preference for traditional medication were still prevalent among the respondents, and they may represent potential barriers to lung cancer screening uptake. A desire to have an early diagnosis (odds ratio [OR], 11.33; 95% confidence interval [CI], 1.53 to 84.05; p=0.02), perceived time constraints (OR, 3.94; 95% CI, 1.32 to 11.73; p=0.01), and proximity of LDCT screening facilities (OR, 14.33; 95% CI, 1.84 to 111.4; p=0.01) had significantly higher odds of willingness to undergo screening.Conclusion: Although high-risk current smokers and ex-smokers are likely to undergo screening for lung cancer, several psychosocial barriers persist. The results of this study may guide the policymakers and clinicians regarding the need to improve lung cancer awareness in our population.
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