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- 저자 : Lifang He (검색결과 5 건)
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Jian He,Xulin Hu,Luyao Xing,Dongliang Chen,Lijun Peng,Gaofeng Liang,Chengdong Xiong,Xiangchun Zhang,Lifang Zhang 한국공업화학회 2021 Journal of Industrial and Engineering Chemistry Vol.99 No.-
Tissue-engineered scaffolds acted as active natural extracellular matrices that allowed for cellattachment, migration, proliferation, and differentiation. To enhance the drug loading, degradationcontrol, and mechanical features of tissue-engineered scaffolds used in bone regeneration applications,we synthesized novel poly(trimethylene carbonate) (PTMC)/modified HA nanoparticles (KHA NPs,modified by silane coupling agent)/vancomycin hydrochloride (VH) porous microspheres scaffold. Thefabricated PTMC/KHA/VH scaffold has unique surface corrosion degradation, excellent surface properties,and high cytocompatibility. The novel PTMC/KHA/VH scaffold was characterized by 42% porosity,100 mmpore size, and 208.2 MPa compressive modulus. After the treatment of a rat femur defect for 4, 8, and 12weeks, the surface corrosion biodegraded of the PTMC/KHA/VH scaffold remarkably decreasedinflammation response and promoted bone regeneration, suggesting its use as a bioactive structurein bone tissue engineering.
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An Effective Krill Herd Algorithm for Numerical Optimization
Songwei Huang,Lifang He,Xu Si,Yuanyuan Zhang,Pengyu Hao 보안공학연구지원센터 2016 International Journal of Hybrid Information Techno Vol.9 No.7
The krill herd (KH) algorithm is a novel swarm intelligent algorithm which is inspired the herding behavior of the krill swarms. The various test results in the relevant literature show that the KH algorithm has better performance than the other swarm intelligent algorithm for optimization problem. In order to further improve the performance of the KH algorithm, an improved KH is proposed in this paper. The algorithm is performed on ten test functions and the results are compared with the basic KH algorithm, PSO, DE and GA algorithm. The experimental results indicate that the improved algorithm is a good method for numerical optimization problem.
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Jinsheng Liao,Qi Wang,Lifang Lan,Jiangfei Guo,Liling Nie,Suijun Liu,He-Rui Wen 한국물리학회 2017 Current Applied Physics Vol.17 No.3
Lu2Ti2O7:Yb3þ/Er3þ (LTO:Yb3þ/Er3þ) nanophosphors codoped with Yb3þ (8e20 at%) and Er3þ ions (0.5 e4 at%) were synthesized by a microwave hydrothermal process. Under the 980 nm excitation, the sample gives a set of upconversion light: very strong red emissions near 661 nm (4F9/2 / 4I15/2), weak green around 523 nm and 545 nm (2H11/2/4I15/2 and 4S3/2/4I15/2, respectively). The optimum doping concentrations of Er3þ and Yb3þ for the highest emission intensity were determined by photoluminescence (PL) analyses. Concentration dependent studies revealed that the optimal composition was realized for the 12 at% Yb3þ and 2.0 at% Er3þ-doping concentration with a strong emission. A possible UC mechanism for LTO:Yb3þ/Er3þ is discussed via the change of the pump power. The temperature dependence of the fluorescence intensity ratios (FIR) for the two green UC emission bands peaked at 523 and 545 nm was studied in the range of 298e573 K under excitation by a 980 nm diode laser and the maximum sensitivity was approximately 0.00313 K『1 at 536 K. This indicates that LTO:Yb3þ/Er3þ nanophosphors are potential candidates for optical temperature sensors with high sensitivity.
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Structure and Photocatalytic Activity of Nitrogen-doped HTiNbO5 Nanosheet Aggregation
Wei Lv,Jie He,Andong Xu,Lifang Hu,Liangguo Da 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2017 NANO Vol.12 No.1
Nitrogen-doped HTiNbO5 nanosheet (N-HTiNbO5-NS) aggregation was successfully obtained through a series of process, including preparation of nitrogen-doped precursor (N-KTiNbO5), proton-exchange of N-KTiNbO5 and exfoliation of N-HTiNbO5. The structures of the as-prepared samples are characterized by means of powder X-ray diffraction (XRD), Scan electron microscopy (SEM), Transmission electron microscopy (TEM), N2 adsorption-desorption isotherms UV-visible diffuse reflectance spectroscopy (UV-Vis-DRS), Laser Raman spectroscopy (LRS), X-ray photoelectron spectroscopy (XPS) and Thermogravimetric analysis-differential scanning calorimetry (TG-DSC). The catalytic activities of the as-prepared samples are evaluated by the photocatalytic degradation of methylene blue (MB) aqueous solution under visible light irradiation. The results reveal that N-HTiNbO5-NS due to the large specific surface area and brilliant visible light response exhibits a relatively excellent photocatalytic activity in the decomposition of MB under visible light irradiation.
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Yixia Xie,Baowei Hu,Yue Gao,Yaxin Tang,Guohe Chen,Jiayuan Shen,Zhikai Jiang,He Jiang,Jiwei Han,Junyan Yan,Lifang Jin 한국통합생물학회 2022 Animal cells and systems Vol.26 No.6
Glycogen storage disease type Ia (GSD-Ia) is caused by a deficiency in the glucose-6-phosphatase (G6Pase, G6pc) enzyme, which catalyses the final step of gluconeogenesis and glycogenolysis. Accumulation of G6pc can lead to an increase in glycogen and development of fatty liver. Ductular reactions refer to the proliferation of cholangiocytes and hepatic progenitors, which worsen fatty liver progress. To date, however, ductular reactions in GSD-Ia remain poorly understood. Here, we studied the development and potential underlying mechanism of ductular reactions in GSD-Ia in mice. We first generated GSD-Ia mice using CRISPR/Cas9 to target the exon 3 region of the G6pc gene. The typical GSD-Ia phenotype in G6pc−/− mice was then analysed using biochemical and histological assays. Ductular reactions in G6pc−/− mice were tested based on the expression of cholangiocytic markers cytokeratin 19 (CK19) and epithelial cell adhesion molecule (EpCAM). Yes-associated protein 1 (Yap) signalling activity was measured using western blot (WB) analysis and quantitative real-time polymerase chain reaction (qRT-PCR). Verteporfin was administered to the G6pc−/− mice to inhibit Yap signalling. The CRISPR/Cas9 system efficiently generated G6pc−/− mice, which exhibited typical GSD-Ia characteristics, including retarded growth, hypoglycaemia, and fatty liver disease. In addition, CK19- and EpCAM-positive cells as well as Yap signalling activity were increased in the livers of G6pc−/− mice. However, verteporfin treatment ameliorated ductular reactions and decreased Yap signalling activity. This study not only improves our understanding of GSD-Ia pathophysiology, but also highlights the potential of novel therapeutic approaches for GSD-Ia such as drug targeting of ductular reactions.
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