TSSG growth, morphology and properties of potassium lithium niobate (KLN) crystals

Chong, Tow-Chong,Xu, Xue-Wu,Li, Lian,Zhang, Guang-Yu,Kumagai, H.,Hirano, M. The Korea Association of Crystal Growth 1999 한국결정성장학회지 Vol.9 No.4

In the present paper, potassium lithium niobate(KLN) crystals have been grown along <001>, <100> and <110> directions by the top seeded solution growth (TSSG) method from Li-richer melts with different compositions. The morphologies of KLN crystals grown along different directions have been studied, and the well-developed facets have been unambiguously indexed using X-ray goniometer and stereographic projection analysis. The growth mechanism and defects such as cracks and inclusions were discussed on the basis of observations of facets on the crystal-solution interfaces. The crystal compositions were determined by a chemical analysis method. The structure and lattice constants of KLN crystals were determined and calculated on the basis of XRD data by using TREOR90 and PIRUM programs. The Curie temperature and optical absorption were determined by dielectric constant peak and spectrum measurements. respectively. The blue second harmonic generation (SHG) characteristics of KLN sample were also investigated using a pulsed dye laser.

Synergistic Effect of Bone Marrow-Derived Mesenchymal Stem Cells and Platelet-Rich Plasma in Streptozotocin-Induced Diabetic Rats

( Zhen Zhen Lian ),( Xiao Jing Yin ),( Hua Li ),( Li Li Jia ),( Xiu Zhen He ),( Yong Bo Yan ),( Nai Hua Liu ),( Ka Yiu Wan ),( Xiao Kun Li ),( Shao Qiang Lin ) 대한피부과학회 2014 Annals of Dermatology Vol.26 No.1

Background: Diabetic wounds are a major clinical challenge, because minor skin wounds can lead to chronic, unhealed ulcers and ultimately result in infection, gangrene, or even amputation. Studies on bone marrow derived mesenchymal stem cells (BMSCs) and a series of growth factors have revealed their many benefits for wound healing and regeneration. Platelet-rich plasma (PRP) may improve the environment for BMSC development and differentiation. However, whether combined use of BMSCs and PRP may be more effective for accelerating diabetic ulcer healing remains unclear. Objective: We investigated the efficacy of BMSCs and PRP for the repair of refractory wound healing in a diabetic rat model. Methods: Forty-eight rats with diabetes mellitus induced by streptozotocin were divided into four groups: treatment with BMSCs plus PRP, BMSCs alone, PRP alone, phosphate buffered saline. The rate of wound closure was quantified. A histopathological study was conducted regarding wound depth and the skin edge at 7, 14, and 28 days after surgery. Results: Wound healing rates were significantly higher in the BMSC plus PRP group than in the other groups. The immunohistochemistry results showed that the expression of platelet/endothelial cell adhesion molecule 1, proliferating cell nuclear antigen, and transforming growth factor-β1 increased significantly in the BMSC plus PRP group compared to the other treatment groups. On day 7, CD68 expression increased significantly in the wounds of the BMSC plus PRP group, but decreased markedly at day 14 compared to the controls. Conclusion: The combination of BMSCs and PRP aids diabetic wound repair and regeneration. (Ann Dermatol 26(1) 1∼10, 2014)

Aloe-emodin Induced Apoptosis in T-HSC/Cl-6 Cells Involves a Mitochondria-Mediated Pathway

Sohn Dong Hwan,Kim So Yeon,Zhao Yu Zhe,Park Eun Jeon,Lian Li Hua 대한약학회 2004 大韓藥學會 總會 및 學術大會 Vol.2004 No.2

Protective effect of acacetin on sepsis-induced acute lung injury via its anti-inflammatory and antioxidative activity

Li-chao Sun,Hong-bo Zhang,Cheng-Dong Gu,Shi-Dong Guo,Gang Li,Rui Lian,Yao Yao,Guo-qiang Zhang 대한약학회 2018 Archives of Pharmacal Research Vol.41 No.12

Sepsis is a clinical syndrome with no effective protective or therapeutic treatments. Acacetin, a natural flavonoid compound, has anti-oxidative and anti-inflammatory effects which can potentially work to reduce sepsis. We investigated the potential protective effect of acacetin on sepsis-induced acute lung injury (ALI) ALI and dissect out the underlying mechanisms. Mice were divided into five groups: a sham group, a sepsis-induced ALI group, and three sepsis groups pre-treated with 20, 40, and 80 mg/kg body weight of acacetin. We found that acacetin significantly attenuated sepsis-induced ALI, in histological examinations and lung edema. Additionally, acacetin treatment decreased protein and inflammatory cytokine concentration and the number of infiltrated inflammatory cells in BALF compared with that in the non-treated sepsis mice. Pulmonary myeloperoxidase (MPO) activity was lower in the acacetin-pre-treated sepsis groups than in the sepsis group. The mechanism underlying the protective effect of acacetin on sepsis is related to the regulation of certain antioxidation genes, including inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), superoxide dismutases (SODs), and heme oxygenase 1 (HO-1).Taken together, our results indicate that acacetin pre-treatment inhibits sepsis-induced ALI through its anti-inflammatory and antioxidative activity, suggesting that acacetin may be a potential protective agent for sepsis-induced ALI.

DNA Methylation in Peripheral Blood: A Potential Biomarker for Cancer Molecular Epidemiology

Li, Lian,Choi, Ji-Yeob,Lee, Kyoung-Mu,Sung, Hyuna,Park, Sue K.,Oze, Isao,Pan, Kai-Feng,You, Wei-Cheng,Chen, Ying-Xuan,Fang, Jing-Yuan,Matsuo, Keitaro,Kim, Woo Ho,Yuasa, Yasuhito,Kang, Daehee Japan Epidemiological Association 2012 Journal of epidemiology Vol.22 No.5

<P>Aberrant DNA methylation is associated with cancer development and progression. There are several types of specimens from which DNA methylation pattern can be measured and evaluated as an indicator of disease status (from normal biological process to pathologic condition) and even of pharmacologic response to therapy. Blood-based specimens such as cell-free circulating nucleic acid and DNA extracted from leukocytes in peripheral blood may be a potential source of noninvasive cancer biomarkers. In this article, we describe the characteristics of blood-based DNA methylation from different biological sources, detection methods, and the factors affecting DNA methylation. We provide a comprehensive literature review of blood-based DNA methylation as a cancer biomarker and focus on the study of DNA methylation using peripheral blood leukocytes. Although DNA methylation patterns measured in peripheral blood have great potential to be useful and informative biomarkers of cancer risk and prognosis, large systematic and unbiased prospective studies that consider biological plausibility and data analysis issues will be needed in order to develop a clinically feasible blood-based assay.</P>

LANDUSE MONITORING BY RS, GIS AND GPS AT COUNTY LEVEL IN CHINA

Li, Xiao Juan,Yin, Lian Wang,Li, Jing 대한원격탐사학회 2000 International Symposium on Remote Sensing Vol.16 No.1

Using the synthetic technology of RS, GPS and GIS to monitor landuse at county level (scale 1:10,000) has characteristics of lower expense, high precision and efficiency. This method is suitable for China and has a great prospective. Landuse monitoring by 3S can be divided into five stages: ① finding out the possible changing area by RS, ②Capturing the spatial data of the changing area by GPS, ③Processing the GPS data, ④Editing GPS data in GIS and ⑤Analysis and output. In this paper, we discuss the techniqueflow and key techniques in each stage of landuse monitoring by 3S. Furthermore, we develop a prototype of a temporal landuse information system (TLIS) which built on a feature-based spatio-temporal data model. This system not only has the functions of traditional GIS but also has the sptio-temporal query and reasoning functions. It can play the process of changing feature instances which let us understand the nature of the landuse changing in spatio-temporal dimensions.

韩国中低端化妆品进入中国市场模式的思考

Li Lian Hua(李莲,花),Li Zhuo(李卓) 대한경영교육학회 2016 경영교육저널 Vol.27 No.1

With the increase of China's national income, people has changed the idea of "beauty" and increased the demand for cosmetics, China has overtaken Japan as the world's second largest cosmetics consumer. As the "Korean wave" isescalating, coupled with the south Korean cosmetics in high technical content, good quality, reasonable price, its share in China has been rising year by year, in 2015, South Korea has surpassed Japan and the United States, became the second largest exporter of cosmetics in China only after France. On December 20th, 2015, China and South Korea free trade agreement(FTA) took effect, it will promote more and more south Korean cosmetics to enter the Chinese market. Almost sixty percent of low and middle in come earners and 37million college students in China, will form the huge mid-range cosmetics consumer groups. As China's "Internet+" and the Wechat business development, China's cosmetics market environment is changing recently. In this background, this paper aims to grasp the new change and put forward some rationalization proposals for the South Korean mid-range cosmetics entering the Chinese market step by step. 随着中国国民收入的增加, 人们对'美'的观念发生了变化, 对化妆品的需求不断增加, 中国已超越日本成长为世界第二大化妆品消费国。随着'韩流'越演越烈, 再加上韩国化妆品技术含量高、品质好, 价格合理, 其在中国的占有率逐年攀升, 2015年, 韩国已超越日本和美国, 成为仅次于法国的第二大对华化妆品出口国。2015年12月20日, 中韩自由贸易协定(FTA)的正式生效, 这将会促进越来越多的韩国化妆品进入中国市场。中国有近六成的中低收入者和3700万的在校大学生, 会形成庞大的中低端化妆品消费群体。随着中国"互联网+"和微商的发展, 目前, 中国化妆品市场销售环境在变化。在这样的背景下, 本文力争把脉新变化, 为韩国中低端化妆品更有步骤的进军中国市场提出几点合理化的建议。

SPECIAL TOPICS IN MARITIME LAW : Marine Insurance Law -General Conditions in Hull, Cargo and P&I Covers

( Lian Jun Li ) 고려대학교 법학연구원 2014 The Asian Business Lawyer Vol.13 No.-

The marine insurance market can represent something of a maze to the un-initiated. Perhaps it is better described as a jigsaw of interlocking covers, often provided by hundreds of individuals or corporate, to make a marine adventure cover whole. The reason for this is largely historic, tracing its routes to the Lloyd’s coffee houses of London, through the American Civil War to the massive expansion of international trade . to this day still heavily reliant on the shipping industry. This article does not intend to provide a complete history of marine insurance, nor a line by line analysis of various hull, cargo and P&I cover. Instead, it will try to provide some historical context to each strand, before reviewing some of the more prevalent clauses and covers in today’s marine underwriting market. It is hoped that the reader will come away from the article with a clearer idea as to who insures what, for how much and why.

Aloe Emodin-Induced Apoptosis in t-HSC/Cl-6 Cells Involves a Mitochondria-Mediated Pathway

Lian, Li-Hua,Park, Eun-Jeon,Piao, Hui-Shan,Zhao, Yu-Zhe,Sohn, Dong Hwan Blackwell Science, Ltd 2005 Basic & Clinical Pharmacology & Toxicology Vol.96 No.6

<P>Abstract: </P><P>The aim of our study was to clarify the apoptosis pathway induced by aloe emodin, an hydroxyanthraquinone present in <I>aloe vera</I> leaves, in rat hepatic stellate cells transformed by simian virus 40 (t-HSC/Cl-6), which retain the features of activated rat stellate cells. Apoptosis was determined by DNA fragmentation, caspase activity assay and western blotting analysis. Treatment of t-HSC/Cl-6 cells with 12.5, 25, or 50 &mgr;M aloe emodin inhibited t-HSC/Cl-6 cell viability in a dose- and time-dependent manner. The induction of apoptosis by aloe emodin was confirmed by typical DNA ladder formation and annexin v-propidium iodide flow-cytometric analysis. Aloe emodin treatment of t-HSC/Cl-6 cells caused activation of caspase-3 and caspase-9, detected with a caspase activity assay, although no change was observed in caspase-8 activity. Western blotting showed caspase-3 and caspase-9 active forms and the subsequent proteolytic cleavage of poly(ADP-ribose) polymerase. Aloe emodin induced mitochondrial membrane depolarization. Our data also show that cytochrome c increased in the cytosol but decreased in the mitochondria in a time-dependent manner. Increased Bax and unchanged Bcl-2 levels resulted in an increased Bax/Bcl-2 ratio. Thus, our research provides evidence that aloe emodin-induced apoptosis involves a mitochondria-associated apoptosis pathway.</P>

High vis-light photocatalytic property of g-C3N4 on four pollutants (RhB, MB, TC-HCl and P-Nitrophenol)

Lian Xiaoxue,Li Yan,Zou Yunling,An Dongmin,Wang Qiong,Zhou Qingjun,Li Xueqi 한국물리학회 2022 Current Applied Physics Vol.39 No.-

The g-C3N4 nanosheets were synthesized by a multistage program calcination with different heating rate, which was an easy, low-cost, and quick method. The morphology and structure of samples were characterized by various techniques. The performance evaluation of the samples was tested by degrading Rhodamine B, Methylene Blue, Tetracycline Hydrochloride and P-Nitrophenol in visible light. The results show that the photodegradation properties of TP-g-C3N4 prepared by multistage program calcination are the best than others. In particular, the degradation rate of TP-g-C3N4 to Rhodamine B reached 99.6% in just 4 min. TP-g-C3N4 catalyst has excellent stability and recycling performance. According to free radical capture experiments, •O2- may be the main active species for pollutant degradation. The possible photocatalytic degradation mechanism was also discussed. Due to the high specific surface area and a narrow band gap, the TP-g-C3N4 becomes a promising photocatalyst.