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FCT 11 : Successful treatment of longitudinal melanonychia with Q-switched Nd:YAG laser
( Gil Han ),( Sang Don Yoon ),( Sung Ae Kim ),( Kyu Suk Lee ) 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.2
Background: Longitudinal melanonychia is a common cosmetic problem in dermatology. To confirm the diagnosis of longitudinal melanonychia and rule out the malignant melanoma, dermatologists recommend patients to get the biopsy of the nail matrix which is painful and can result in permanent nail dystrophy. Objectives: The purpose of this study is to investigate the effect of Q-switched Nd:YAG laser in patients with longitudinal melanonychia without malignant melanoma risk. Methods: 10 patients were enrolled. We selected the patients who has longitudinal melanonychia without any malignantrisk through clinical appearance and dermoscopic finding. Two to four sessions of Q-switched Nd:YAG laser treatment were performed to patients depending on their individual melanonychia states. Improvement was evaluated using visual analoque scale by both dermatologists and patients. Results: All longitudinal melanonychia showed remarkableimprovement after two to four sessions of treatment. The remained lesions were completely treated within additional two sessions. Clinical improvement were very good or good in both dermatologists and no recurrence was observed during the follow up period.Conclusion: In conclusion, we suggest that Q-switched Nd:YAG laser is a safe and effective treatment option for stable longitudinal melanonychia.
Sung-Hwa Kang,Shin Hwang,Tae-Yong Ha,Gi-Won Song,Dong-Hwan Jung,Ki-Hun Kim,Chul-Soo Ahn,Deok-Bog Moon,Gil-Chun Park,Bo-Hyun Jung,Young-In Yoon,Sung-Gyu Lee 한국간담췌외과학회 2014 한국간담췌외과학회지 Vol.18 No.2
Backgrounds/Aims: There are few guidelines for tailored immunosuppressive regimens for liver transplantation (LT) recipients with hepatocellular carcinoma (HCC). To establish long-term immunosuppressive regimens suitable for Korean adult LT recipients, we analyzed those that were currently in use at a single high-volume institution. Methods: This cross-sectional study comprises three parts including review of the immunosuppressive regimens used to manage 2,147 adult LT outpatients, review of LT recipients who were diagnosed of HCC at LT, and review of LT recipients who suffered from HCC recurrence. Results: In 1,000 adult LT recipients who were living more than 5 years with no adverse events, 916 received a calcineurin inhibitor (CNI)-based therapy (CNI only in 520; CNI with mycophenolate mofetil [MMF] in 396) and 84 were receiving an MMF-based therapy (MMF only in 45; MMF with minimal CNI in 39). Tacrolimus was preferred over cyclosporine for both monotherapy and combination therapy along the passage of posttransplant period. There was no difference in selection of immunosuppressants, target blood concentration, and rate of combination therapy between LT recipients with and without HCC, except for the first 1 year. Sirolimus-based regimens were applied in 21 patients who showed HCC recurrence. Sorafenib was often used after conversion to sirolimus. Conclusions: Tailored immunosuppressive regimen covering the long-term posttransplant period should be established after consideration of individualized patient profiles including HCC.
BAYESIAN INFERENCE FOR FIELLER-CREASY PROBLEM USING UNBALANCED DATA
Lee, Woo-Dong,Kim, Dal-Ho,Kang, Sang-Gil The Korean Statistical Society 2007 Journal of the Korean Statistical Society Vol.36 No.4
In this paper, we consider Bayesian approach to the Fieller-Creasy problem using noninformative priors. Specifically we extend the results of Yin and Ghosh (2000) to the unbalanced case. We develop some noninformative priors such as the first and second order matching priors and reference priors. Also we prove the posterior propriety under the derived noninformative priors. We compare these priors in light of how accurately the coverage probabilities of Bayesian credible intervals match the corresponding frequentist coverage probabilities.