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1-Chloro-1-phenyl-2-carboethoxy-2-cyanoethene 유도체에 대한 thioglycolic acid 치환제의 합성
이영행,이채호,이갑상,이만구 圓光大學校 1984 論文集 Vol.18 No.2
The substitution products of thioglycolic acid to the derivatives of 1-chloro-1-phenyl-2-carboethoxy-e-cyano ethene synthesized 1-Chloro-1-phenyl-2-carboethoxy-2-cyanoethene [Ⅴ], 1-chloro-10(4-chlorophenyl)-2-carboethoxy-2-cyanoethene[Ⅳ] and 1-chloro-1-(4-methoxyphenyl)-2-carboethoxy-2-cyanoethene[Ⅶ] undergo substitution reactions with thioglycolic acid to form s-[(1-phenyl-2-carboethoxy-2-cyano) ethenyl]-thioglycolic acid s-[(1-(4-chlorophenyl)-2-carboethoxy-e-cyano] ethenyl]-thioglycolic acid and s-[1-(4-methoxyphenyl)-2-carboethoxy-2-cyano] ethenyl]-thioglycolic acid, respectively. The structure of products were identified by elemental analysis, potentiometric titration, infrared and nmr spectra.
Diethyl 3,4,5, - Trimethoxybenzylmalonate의 새로운 합성법
李茶浩,李英行,李晩求,蔡奎允 圓光大學校 1984 論文集 Vol.18 No.2
3,4,5 - Trimethoxybenjoyl chloride 와 diethyl malonate를 축합시키고 이어서 염소화반응 및 수소화반응에 의하여 70%의 수득률로서 diethyl 3,4,5 - trimethoxybenzylmalonate를 얻었다. direct condensation of 3,4,5 - trimethoxybenzoyl chloried with diethyl malonate followed by chlorination and hydrogenation afforded diethyl 3,4,5 - trimethoxybenzylmalonate in 70% overall yield.
2,4-Diamino-5-(3´, 4´, 5´-trimethoxybenzyl) pyrimidine의 합성에 관한 연구
李寀浩 圓光大學校 基礎自然科學硏究所 1984 基礎科學硏究誌 Vol.3 No.1
The reactions of β-morpholino-α-3,4,5-trimethoxybenzylacrylonitrile with p-substituted aniline followed by cyclization affored 2,4-diamino-5-(3', 4', 5'-trimethoxybenzyl) pyrimidine in 85∼95% overall yield.
α-Methyl Dl-N-Benzylaspartate의 합성
이채호,조성동,이만구,채규윤 圓光大學校 基礎自然科學硏究所 1987 基礎科學硏究誌 Vol.6 No.1
Synthesis of α-methyl N-benzylaspartates from DL-aspartic acid is described. DL-Aspartic acid was transformed in several ways into DL-aspartic anhydride which was subjected to alcoholysis in methanol. Benzylation of the resulting a-methyl DL-aspartate with benzyl bromide produced a-methyl β-benzyl DL-N-benzylaspartate. Hydrogenolysis of this ester was converted to α-methyl DL-N-benzylaspartate.
1,2,3,4-Tetrahydroisoquinoline 유도체의 합성
이지선,이채호 圓光大學校 基礎自然科學硏究所 2001 基礎科學硏究誌 Vol.19 No.1
Formic acid내에서 N,N'-bis(2-arylethy1)sulfamide로부터 a-sulfamido-alkylation 반응을 이용하여 bis[2-(1,2,3,4-tetrahydroisoquinoliny1)]sulfone유도체를 합성하였다.
李寀浩,李英行 圓光大學校 1982 論文集 Vol.16 No.2
Trimethoprim은 그람음성균과 변형균에 대하여 광범위한 항균력을 가진다. Trimethoprim은 흔히 3,4,5-trimethoxybenzaldelyde를 출발물질로 사용하여 합성되며 그 합성자체가 복잡하고 어려운 점이 많다. 이러한 어려운 점을 피하기 위하여 3,4,5-trimethoxybenzoic acid를 출발물질로 사용하였으며 그의 acid chloride와 ethyl cyanoacetate나 diethyl malonate를 축합시켜서 Trimethoprim의 중간체인 diethyl 3,4,5-trimethoxybenzolymalonate와 diethyl 3,4,5-trimethoxybenzylmalonate를 합성하였다. Trimethoprim has a moderately broad antibacterial spectrum which includes many of the gram-negative species. This compound has always been synthesized starting from 3,4,5-trimethoxy benzaldebyde, but the synthesis of the starting material itself were very complicated and tedious. To avoid these difficulties, we used 3,4,5-trimethoxybenzoic acid as starting material and attempted to condense ethyl cyanoacetate and diethyl malonate with 3,4,5-trimethoxybenzoyl chloride. As a result, the intermediates for the synthesis of trimethoprim, diethyl 3,4,5-trimethoxybenzoylmalonate and diethyl 3,4,5-trimethoxybenzylmalonate were synthesized.
1,4,5,6-Tetrahydro-1-methyl-2-styrylpyrimidine의 합성에 관한 연구
李寀浩,鄭在奎 圓光大學校 基礎自然科學硏究所 1983 基礎科學硏究誌 Vol.2 No.1
Broad-spectrum anthelmintic activity has been discovered in a series of tetrahydropyrimidines substituted variousely at the 2-position by 2-arylethy1 or 2-arylviny1 group. These anthelmintic agents were prepared starting from the corresponding arylaldehyde. 1,4,5,6-Tetrahydro-1-methy1-2styrylpyrimidine which is the simplest in a series of tetrahydropyrimidines was prepared starting from benzoy1 chloride, instead of benzaldehyde.
α-Alkyl N-Benzylaspartates의 합성
이채호,이만구,채규윤 圓光大學校 基礎自然科學硏究所 1986 基礎科學硏究誌 Vol.5 No.2
Synthesis of α-alkyl N-benzylates from maleic anhydride is described. Maleic anhydride was transformed into monoalkyl maleates which were treated which benzylamine to afford β-alkyl N-benzylaspartates(alkyl=methyl and benzyl). Base hydrolysis of these esters and subsequent treatment of the resulting carboxylic acid with HBr in AcOH produced N-benzylaspartic anhydride hydrobromide. Alcoholysis of this salts in methanol and benzyl alchol yielded α-methyl N-benzyl-aspartate and α-benzyl N-benzylaspartate, respectively.
채수경,김미자,이광원,손호현 全北大學校 齒醫學硏究所 1991 전북치대논문집 Vol.9 No.1
The purpose of this study was to evaluate the effect of various dentin adhesives on the incisal and gingival marginal leakage of class Ⅴ cavity. V-shape cavities with enamel bevel (0.7-1㎜) were prepared on the faciocervical area of 72 extracted human anterior teeth. Gingival margin of cavities was placed on dentin or cementum. Including 1 group with no dentin treatment, they were divided into 6 groups according to dentin surface treatment with Scotchprep(3M Co.), Prisma Universal Bond 2(Dentsply Inter. Inc.), Gluma(Cloumbus/Bayer), All BOND 2(Bisco inc.) and Denthesive(Kulzer Co.). After dentin treatment, Dentin adhesive(3M Co.) was applied on the treated dentin surface and Silux("U" shade, 3M Co.) was filled and polished. Dye penetration technique using 2% methylene blue solution was adopted to assess incisal and gingival marginal leakage. The following results were obtained 1. The degree of incisal marginal leakage in the non-treated group was greater than that in other groups(p<0.01), and incisal marginal leakage in the groups treated with All BOND 2, and Denthesive was less than that in the group treated with Gluma(P<0.01). 2. Incisal marginal leakage in the groups treated with Prisma Universal Bond 2, and Scotchprep was less than that in the group treated with Gluma(p<0.01). 3. Incisal marginal leakage among the groups treated with Scotchprep, Prisma Universal Bond 2, All BOND 2 and Denthesive was not different(p>0.05). 4. The degree of gingival marginal leakage in the non-treated group was significantly greater than that in other groups(p<0.01). 5. Gingival marginal leakage among the groups treated with Scotchprep, Prisma Universal Bond 2, Gluma, All BOND 2, and Denthesive was not statistically significant(p>0.05). But gingival marginal leakage was significantly less in the All BOND 2 treated group compared with Gluma treated group(p<0.05).