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Erlotinib Induced Trichomegaly of the Eyelashes
Sang Hoon Jeon,Jeong Seon Ryu,Gwang Seong Choi,Jung Soo Kim,Hea Yoon Kwon,Min Su Kim,Hae Seong Nam,Jae Hwa Cho,Seung Min Kwak,Hong Lyeol Lee,Hyun Jung Kim,Geun Jeong Hong 대한결핵 및 호흡기학회 2013 Tuberculosis and Respiratory Diseases Vol.74 No.1
Epithelial growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) have been widely used for non-small-cell lung cancer patients. Its untoward cutaneous effects are largely well known and developed in many patients treated with EGFR TKIs. However trichomegaly of eyelash is rarely reported. Although trichomegaly is not a drug-limiting side effect, it could be troublesome of continuing the treatment because of cosmetic issue or eyeball irritation by long eyelashes. Therefore clinicians are needed to pay attention to this uncommon effect. We herein describe erlotinib induced trichomegaly of eyelashes in a woman with adenocarcinoma of the lung.
Kwak, Soo Heon,Park, Young Joo,Go, Min Jin,Lee, Kyu Eun,Kim, Su-jin,Choi, Hoon Sung,Kim, Tae Hyuk,Choi, Sung Hee,Lim, Soo,Kim, Ki Woong,Park, Do Joon,Kim, Sung Soo,Lee, Jong-Young,Park, Kyong Soo,Jang IRL Press 2014 Human molecular genetics Vol.23 No.16
<P>Genetic factors are thought to be an important determinant of thyroid function and autoimmunity. However, there are limited data on genetic variants in Asians. In this study, we performed a genome-wide association study on plasma thyroid-stimulating hormone (TSH) and free thyroxine (fT<SUB>4</SUB>) concentration and anti-thyroid peroxidase (anti-TPO) antibody positivity in 4238 Korean subjects. In the Stage 1 genome scan, 3396 participants from the Ansung cohort were investigated using 1.42 million genotyped or imputed markers. In the Stage 2 follow-up, 10 markers were genotyped in 842 participants from the Korean Longitudinal Study on Health and Aging cohort. An intronic variant in <I>VAV3,</I> rs12126655, which has been reported in Europeans, was significantly associated with plasma TSH concentration in the joint Stages 1 and 2 analyses (<I>P</I> = 2.2 × 10<SUP>−8</SUP>). We observed that a novel variant, rs2071403, located 75 bp proximal to the translational start site of <I>TPO</I> was significantly associated with plasma anti-TPO antibody positivity in the joint Stages 1 and 2 analyses (<I>P</I> = 1.3 × 10<SUP>−10</SUP>). This variant had a marginal sex-specific effect, and its association was more significant in females. Subjects possessing the rs2071403A allele, associated with an absence of the anti-TPO antibody, had decreased TPO mRNA expression in their thyroid tissue. Another intronic variant of <I>HLA-DPB2</I>, rs733208, had a suggestive association with anti-TPO antibody positivity (<I>P</I> = 4.2 × 10<SUP>−7</SUP>). In conclusion, we have identified genetic variants that are strongly associated with TSH level and anti-TPO antibody positivity in Koreans. Further replications and meta-analysis are required to confirm these findings.</P>
A Genome-Wide Association Study of Gestational Diabetes Mellitus in Korean Women
Kwak, Soo Heon,Kim, Sung-Hoon,Cho, Young Min,Go, Min Jin,Cho, Yoon Shin,Choi, Sung Hee,Moon, Min Kyong,Jung, Hye Seung,Shin, Hyoung Doo,Kang, Hyun Min,Cho, Nam H.,Lee, In Kyu,Kim, Seong Yeon,Han, Bok- American Diabetes Association 2012 Diabetes Vol.61 No.2
<P><B/></P><P>Knowledge regarding the genetic risk loci for gestational diabetes mellitus (GDM) is still limited. In this study, we performed a two-stage genome-wide association analysis in Korean women. In the stage 1 genome scan, 468 women with GDM and 1,242 nondiabetic control women were compared using 2.19 million genotyped or imputed markers. We selected 11 loci for further genotyping in stage 2 samples of 931 case and 783 control subjects. The joint effect of stage 1 plus stage 2 studies was analyzed by meta-analysis. We also investigated the effect of known type 2 diabetes variants in GDM. Two loci known to be associated with type 2 diabetes had a genome-wide significant association with GDM in the joint analysis. rs7754840, a variant in <I>CDKAL1</I>, had the strongest association with GDM (odds ratio 1.518; <I>P</I> = 6.65 × 10<SUP>−16</SUP>). A variant near <I>MTNR1B</I>, rs10830962, was also significantly associated with the risk of GDM (1.454; <I>P</I> = 2.49 × 10<SUP>−13</SUP>). We found that there is an excess of association between known type 2 diabetes variants and GDM above what is expected under the null hypothesis. In conclusion, we have confirmed that genetic variants in <I>CDKAL1</I> and near <I>MTNR1B</I> are strongly associated with GDM in Korean women. There seems to be a shared genetic basis between GDM and type 2 diabetes.</P>
Kwak Dae-hoon,Nam Jae-sung J-INSTITUTE 2016 Public Value Vol.1 No.2
Since the late 1970s and early 1980s, community policing has been adopted in most of police agencies in the United States as well as many other countries to improve overall effectiveness of police departments and en-hance citizen’s perception toward police. Under the philosophy of community policing, police-community rela-tion is considered as one of important elements to success their missions. That is, effective community policing requires input of citizens regarding the needs and problems of the community. Thus, public attitude toward police can be very influential and should be one that is positive. For instance, there has always existed a cyclical relationship between the police and the public: distrust towards the police affects their effectiveness of crime control, which leads to an increase in crime that, ultimately, results in further distrust. Nationwide, principally in countries that have a widespread allocation of poverty and interference from an overreaching state or gov-ernment, law enforcement has been viewed particularly disapprovingly and untrusting due to past behaviors of their own police involved in corruption and dishonesty. Although there has been an extensive body of research that has been conducted on public confidence in the police, there has been limited research that has focused on press freedom and other nations. The purpose of current study, therefore, is to shed light on the public confidence in police across 15 OECD countries using the World Value Survey (2010-2014). Moreover, the study attempts to determine how press freedom influences the public confidence in policing forces across 15 countries. The findings from this study partially supported our research hypothesis where press freedom positively in-fluenced public confidence in the police agencies across the OECD countries. More specifically, consistent with prior research, individual characteristics of the respondents were statistically significant while the press free-dom became a non-significant factor on police confidence. In particular, people who were older, female, and have a high level of education tend to report a higher level of police confidence. In addition, two country level variables were statistically significant. That is, crime rates had a negative impact on police confidence while economic growth were positively related to the police confidence. Although the current study improves our understanding of the effect of press freedom on police confidence, there are several limitations, and future study needs to be conducted to better understand police confidence. Finally, implications for practice and fu-ture research are discussed.
Kwak, Seong-Sung,Jang, Seung-Hoon,Jeong, Se-Heon,Jeon, Yubyeol,Biswas, Dibyendu,Hyun, Sang-Hwan 韓國受精卵移植學會 2012 한국동물생명공학회지 Vol.27 No.3
The 3-isobutyl-1-methylxanthine (IBMX) is non-selective phosphodiesterase and is able to prevent resumption of meiosis by maintaining elevated cyclic AMP (cAMP) concentrations in the oocyte. The present study was conducted to analyze: (1) nuclear maturation (examined by the Hoechst staining), (2) whether cytoplasmic maturation (examined by the intracellular glutathione (GSH) concentration) of porcine oocytes is improved during meiotic arrest after prematuration (22 h) with IBMX. Before in vitro maturation (IVM), oocytes were treated with 1 mM IBMX for 22 h. After 22 h of pre-maturation, the higher rate of IBMX treated group oocytes were arrested at the germinal vesicle (GV) stage (42.3%) than control IVM oocytes (10.1%). It appears that the effect of IBMX on the resumption of meiosis has shown clearly. In the end of IVM, the reversibility of the IBMX effect on the nuclear maturation has been corroborated in this study by the high proportions of MII stage oocytes (72.5%) reached after 44 h of IVM following the 22 h of inhibition. However, intracellular GSH concentrations were lower in the oocytes treated with IBMX than the control oocytes (6.78 and 12.94 pmol/oocyte, respectively). These results demonstrate that cytoplasmic maturation in porcine oocytes pre-treated with IBMX for 22 h did not equal that of control oocytes in the current IVM system. These results indicate that pre-maturation with IBMX for 22 h may not be beneficial in porcine IVM system.