L-erothioneine level in red blood cells of healthy human males in the Western province of Saudi Arabia

TahaA.Kumosani 생화학분자생물학회 2001 Experimental and molecular medicine Vol.33 No.1

A survey of cyclic and linear siloxanes in indoor dust and their implications for human exposures in twelve countries

Tran, Tri Manh,Abualnaja, Khalid O.,Asimakopoulos, Alexandros G.,Covaci, Adrian,Gevao, Bondi,Johnson-Restrepo, Boris,Kumosani, Taha A.,Malarvannan, Govindan,Minh, Tu Binh,Moon, Hyo-Bang,Nakata, Haruhi Elsevier 2015 Environment international Vol.78 No.-

<P><B>Abstract</B></P> <P>Siloxanes are used widely in a variety of consumer products, including cosmetics, personal care products, medical and electrical devices, cookware, and building materials. Nevertheless, little is known on the occurrence of siloxanes in indoor dust. In this survey, five cyclic (D3–D7) and 11 linear (L4–L14) siloxanes were determined in 310 indoor dust samples collected from 12 countries. Dust samples collected from Greece contained the highest concentrations of total cyclic siloxanes (TCSi), ranging from 118 to 25,100ng/g (median: 1380), and total linear siloxanes (TLSi), ranging from 129 to 4990ng/g (median: 772). The median total siloxane (TSi) concentrations in dust samples from 12 countries were in the following decreasing order: Greece (2970ng/g), Kuwait (2400), South Korea (1810), Japan (1500), the USA (1220), China (1070), Romania (538), Colombia (230), Vietnam (206), Saudi Arabia (132), India (116), and Pakistan (68.3). TLSi concentrations as high as 42,800ng/g (Kuwait) and TCSi concentrations as high as 25,000ng/g (Greece) were found in indoor dust samples. Among the 16 siloxanes determined, decamethylcyclopentasiloxane (D5) was found at the highest concentration in dust samples from all countries, except for Japan and South Korea, with a predominance of L11; Kuwait, with L10; and Pakistan and Romania, with L12. The composition profiles of 16 siloxanes in dust samples varied by country. TCSi accounted for a major proportion of TSi concentrations in dust collected from Colombia (90%), India (80%) and Saudi Arabia (70%), whereas TLSi predominated in samples collected from Japan (89%), Kuwait (85%), and South Korea (78%). Based on the measured median TSi concentrations in indoor dust, we estimated human exposure doses through indoor dust ingestion for various age groups. The exposure doses ranged from 0.27 to 11.9ng/kg-bw/d for toddlers and 0.06 to 2.48ng/kg-bw/d for adults.</P> <P><B>Highlights</B></P> <P> <UL> <LI> 5 cyclic and 11 linear siloxanes were determined in 310 indoor dust from 12 countries. </LI> <LI> Linear siloxane concentrations as high as 42,800ng/g and cyclic siloxanes as high as 25,000ng/g were found. </LI> <LI> Decamethylcyclopentasiloxane (D5) was found at the highest concentration in dust from most countries. </LI> <LI> The exposure doses of siloxanes through dust were below 10ng/kg-bw/d. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

A comparative assessment of human exposure to tetrabromobisphenol A and eight bisphenols including bisphenol A via indoor dust ingestion in twelve countries

Wang, Wei,Abualnaja, Khalid O.,Asimakopoulos, Alexandros G.,Covaci, Adrian,Gevao, Bondi,Johnson-Restrepo, Boris,Kumosani, Taha A.,Malarvannan, Govindan,Minh, Tu Binh,Moon, Hyo-Bang,Nakata, Haruhiko,Si Elsevier 2015 Environment international Vol.83 No.-

<P><B>Abstract</B></P> <P>Tetrabromobisphenol A (TBBPA) and eight bisphenol analogues (BPs) including bisphenol A (BPA) were determined in 388 indoor (including homes and microenvironments) dust samples collected from 12 countries (China, Colombia, Greece, India, Japan, Kuwait, Pakistan, Romania, Saudi Arabia, South Korea, U.S., and Vietnam). The concentrations of TBBPA and sum of eight bisphenols (ƩBPs) in dust samples ranged from <1 to 3600 and from 13 to 110,000ng/g, respectively. The highest TBBPA concentrations in house dust were found in samples from Japan (median: 140ng/g), followed by South Korea (84ng/g) and China (23ng/g). The highest ∑BPs concentrations were found in Greece (median: 3900ng/g), Japan (2600ng/g) and the U.S. (2200ng/g). Significant variations in BPA concentrations were found in dust samples collected from various microenvironments in offices and homes. Concentrations of TBBPA in house dust were significantly correlated with BPA and ∑BPs. Among the nine target chemicals analyzed, BPA was the predominant compound in dust from all countries. The proportion of TBBPA in sum concentrations of nine phenolic compounds analyzed in this study was the highest in dust samples from China (27%) and the lowest in Greece (0.41%). The median estimated daily intake (EDI) of ∑BPs through dust ingestion was the highest in Greece (1.6–17ng/kgbw/day), Japan (1.3–16) and the U.S. (0.89–9.6) for various age groups. Nevertheless, in comparison with the reported BPA exposure doses through diet, dust ingestion accounted for less than 10% of the total exposure doses in China and the U.S. For TBBPA, the EDI for infants and toddlers ranged from 0.01 to 3.4ng/kgbw/day, and dust ingestion is an important pathway for exposure accounting for 3.8–35% (median) of exposure doses in China.</P> <P><B>Highlights</B></P> <P> <UL> <LI> TBBPA and bisphenols were measured in 388 indoor dust samples from 12 countries. </LI> <LI> The contribution of house dust to daily intakes of TBBPA and BPA varied among countries. </LI> <LI> Dust is an important source of TBBPA exposures in China, Japan and South Korea. </LI> <LI> Dust ingestion accounted for 3.8–35% (median) of TBBPA exposure in China. </LI> <LI> Contribution of dust to BPA intake is minor. </LI> </UL> </P>

Synthetic Phenolic Antioxidants and Their Metabolites in Indoor Dust from Homes and Microenvironments

Wang, Wei,Asimakopoulos, Alexandros G.,Abualnaja, Khalid O.,Covaci, Adrian,Gevao, Bondi,Johnson-Restrepo, Boris,Kumosani, Taha A.,Malarvannan, Govindan,Minh, Tu Binh,Moon, Hyo-Bang,Nakata, Haruhiko,Si American Chemical Society 2016 Environmental science & technology Vol.50 No.1

<P>Synthetic phenolic antioxidants (SPAs), including 2,6-di-tert-butyl-4-hydroxytoluene (BHT), are extensively used in food, cosmetic and plastic industries. Nevertheless, limited information is available on human exposures, other than the dietary sources, to SPAs. In this study, occurrence of 9 SPAs and their metabolites/degradation products was determined in 339 indoor dust collected from 12 countries. BHT was found in 99.5% of indoor dust samples from homes and microenvironments at concentrations that ranged from < LOQ to 118 mu g/g and 0.10 to 3460 mu g/g, respectively. This is the first study to measure BHT metabolites in house dust (0.01-35.1 mu/g) and their concentrations accounted for 9.2-58% of the sum concentrations (Sigma SPAs). 3,5-di-tert-butyl-4-hydroxybenzaldehyde (BHT-CHO), 2,6-di-tert-butyl-4-(hydroxymethyl)phenol (BHT OH), 2,6-di-tert-butyl-1,4-benzoquinone (BHT-Q) were the major derivatives of BHT found in dust samples. The concentrations of gallic acid esters (gallates) in dust from homes and microenvironments ranged from < LOQ to 18.2 and < LOQ to 684 mu g/g, respectively. The concentrations and profiles of SPAs varied among countries and microenvironments. Significantly elevated concentrations of SPAs were found in dust from an e-waste workshop (1530 mu g/g). The estimated daily intake (EDT) of BHT via house dust ingestion ranged from 0.40 to 222 ng/kg/d (95th percentile).</P>

Epigallocatechin-3-gallate Inhibits Tax-dependent Activation of Nuclear Factor Kappa B and of Matrix Metalloproteinase 9 in Human T-cell Lymphotropic Virus-1 Positive Leukemia Cells

Harakeh, Steve,Diab-Assaf, Mona,Azar, Rania,Hassan, Hani Mutlak Abdulla,Tayeb, Safwan,Abou-El-Ardat, Khalil,Damanhouri, Ghazi Abdullah,Qadri, Ishtiaq,Abuzenadah, Adel,Chaudhary, Adeel,Kumosani, Taha,N Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.3

Epigallocatechin-3-gallate (EGCG) is the most abundant polyphenol molecule from green tea and is known to exhibit antioxidative as well as tumor suppressing activity. In order to examine EGCG tumor invasion and suppressing activity against adult T-cell leukemia (ATL), two HTLV-1 positive leukemia cells (HuT-102 and C91-PL) were treated with non-cytotoxic concentrations of EGCG for 2 and 4 days. Proliferation was significantly inhibited by 100 ${\mu}M$ at 4 days, with low cell lysis or cytotoxicity. HTLV-1 oncoprotein (Tax) expression in HuT-102 and C91-PL cells was inhibited by 25 ${\mu}M$ and 125 ${\mu}M$ respectively. The same concentrations of EGCG inhibited NF-kB nuclearization and stimulation of matrix metalloproteinase-9 (MMP-9) expression in both cell lines. These results indicate that EGCG can inhibit proliferation and reduce the invasive potential of HTLV-1-positive leukemia cells. It apparently exerted its effects by suppressing Tax expression, manifested by inhibiting the activation of NF-kB pathway and induction of MMP-9 transcription in HTLV-1 positive cells.