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      • KCI등재

        Hydrolytic Enzyme Protease in Sludge: Recovery and Its Application

        Santosh Kumar Karn,Awanish Kumar 한국생물공학회 2015 Biotechnology and Bioprocess Engineering Vol.20 No.4

        Excess of sludge generated by industries and municipal waste treatment is becomes a serious issue, mainly due to the growth of population and urbanization or development of new cities and the increases in the industrial activity. Protease refers to a group of important enzymes that hydrolyze or breakdown the protein molecules and involved in variety of biochemical pathways in living cells. They are required for many cellular functions because they are very useful in the digestion as they breakdown the peptide bonds in the protein of food stuff and liberate the amino acids needed for the body. Proteases have been used for a long time in various forms of therapy and industrial application. Industries like paper mills, pulp mills, textile industries and leather industries generate significant amounts of biodegradable sludge. This sludge is an industrial waste and contaminates the environment. Microorganisms degrade this sludge and produce protease and other hydrolytic enzymes. Biodegradation of the industrial sludge would be a great effort in terms of waste management as well as recovery of valuable protease for multifarious application. Emerging evidence from the literature proves the competence and vast application of protease for mankind. It has been used in many applications in the fields of food, medicine, fabric, leather in past decades. Present manuscript describes the key issues related to protease recovery from different industrial and municipal sludge using different approaches and its potential application in life.

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        Scientific rationale of Indian AYUSH Ministry advisory for COVID-19 prevention, prophylaxis, and immunomodulation

        Prashant Kumar Gupta,Kishor Sonewane,Mariappan Rajan,Nitin J. Patil,Trapti Agrawal,Ena Ray Banerjee,Nagendra Singh Chauhan,Awanish Kumar 경희대학교 융합한의과학연구소 2023 Oriental Pharmacy and Experimental Medicine Vol.23 No.2

        The current outbreak of COVID-19 is caused by the SARS-CoV-2 virus that has affected > 210 countries. Various steps are taken by different countries to tackle the current war-like health situation. In India, the Ministry of AYUSH released a self-care advisory for immunomodulation measures during the COVID-19 and this review article discusses the detailed scientific rationale associated with this advisory. Authors have spotted and presented in-depth insight of advisory in terms of immunomodulatory, antiviral, antibacterial, co-morbidity associated actions, and their probable mechanism of action. Immunomodulatory actions of advised herbs with no significant adverse drug reaction/toxicity strongly support the extension of advisory for COVID-19 prevention, prophylaxis, mitigations, and rehabilitation capacities. This advisory also emphasized Dhyana (meditation) and Yogasanas as a holistic approach in enhancing immunity, mental health, and quality of life. The present review may open-up new meadows for research and can provide better conceptual leads for future researches in immunomodulation, antiviral-development, psychoneuroimmunology, especially for COVID-19.

      • KCI등재

        Spontaneous Rectal Perforation with Transanal Evisceration of the Small Bowel: A Rare Case Report

        Pal Ajay Kumar,Kumar Prasoon,Yadav Dhirendra,Kumar Awanish,Pahwa Harvinder Singh,Singh Krishna Kant 대한외상중환자외과학회 2022 Journal of Acute Care Surgery Vol.12 No.2

        Transanal evisceration of the small bowel is a rare surgical emergency. Rectal perforation in such cases is usually due to an underlying rectal prolapse. We report a case of a middle aged (45 years) male with spontaneous rectal perforation and transanal evisceration of the small bowel. Approximately 150 cm of small bowel had eviscerated transanally and the patient required emergent abdominal exploration, reposition of the small bowel, and repair of the rectal perforation. Small bowel evisceration through the anal verge is an emergent condition and the aim was to prevent life threatening complications related to sepsis.

      • Low energy ultrasonic single beacon localization for testing of scaled model vehicle

        Dubey, Awanish C.,Subramanian, V. Anantha,Kumar, V. Jagadeesh Techno-Press 2019 Ocean systems engineering Vol.9 No.4

        Tracking the location (position) of a surface or underwater marine vehicle is important as part of guidance and navigation. While the Global Positioning System (GPS) works well in an open sea environment but its use is limited whenever testing scaled-down models of such vehicles in the laboratory environment. This paper presents the design, development and implementation of a low energy ultrasonic augmented single beacon-based localization technique suitable for such requirements. The strategy consists of applying Extended Kalman Filter (EKF) to achieve location tracking from basic dynamic distance measurements of the moving model from a fixed beacon, while on-board motion sensor measures heading angle and velocity. Iterative application of the Extended Kalman Filter yields x and y co-ordinate positions of the moving model. Tests performed on a free-running ship model in a wave basin facility of dimension 30 m by 30 m by 3 m water depth validate the proposed model. The test results show quick convergence with an error of few centimeters in the estimated position of the ship model. The proposed technique has application in the real field scenario by replacing the ultrasonic sensor with industrial grade long range acoustic modem. As compared with the existing systems such as LBL, SBL, USBL and others localization techniques, the proposed technique can save deployment cost and also cut the cost on number of acoustic modems involved.

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