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RISS 인기검색어
- 검색키워드
- 저자 : Krzysik, Lisa (검색결과 4 건)
- 무료
- 기관 내 무료
- 유료
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Emotion Expressiveness and Knowledge in Preschool-Age Children: Age-Related Changes
Shin, Nana,Krzysik, Lisa,Vaughn, Brian E. Korean Association of Child Studies 2014 Child studies in Asia-Pacific context Vol.4 No.1
Emotion is a central feature of social interactions. In this study, we examined age-related changes in emotion expressiveness and emotion knowledge and how young children's emotion expressiveness and knowledge were related. A total of 300 children attending a daycare center contributed data for the study. Observation and interview data relevant to measures of emotion expressiveness and knowledge were collected and analyzed. Both emotion knowledge and expressed positive affect increased with age. Older preschool children expressed positive affect more frequently than did younger preschoolers. Older preschool children also labeled, recognized, and provided plausible causes mores accurately than did younger preschool children. In addition, we tested whether children's errors on the free labeling component conform to the structural model previously suggested by Bullock and Russell (1986) and found that preschool children were using systematic strategies for labeling emotion states. Relations between emotion expressiveness and emotion knowledge generally were not significant, suggesting that emotional competence is only gradually constructed by the child over the preschool years.
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Blockade of cannabinoid 1 receptor improves GLP-1R mediated insulin secretion in mice
Gonzalez-Mariscal, I.,Krzysik-Walker, S.M.,Kim, W.,Rouse, M.,Egan, J.M. North-Holland 2016 Molecular and cellular endocrinology Vol.423 No.-
<P>The cannabinoid 1 receptor (CBI) is an important regulator of energy metabolism. Reports of in vivo and in vitro studies give conflicting results regarding its role in insulin secretion, possibly due to circulatory factors, such as incretins. We hypothesized that this receptor may be a regulator of the entero-insular axis. We found that despite lower food consumption and lower body weight postprandial GLP-1 plasma concentrations were increased in CB1(-/-) mice compared to CB1(+/+) mice administered a standard diet or high fat/sugar diet. Upon exogenous GLP-1 treatment, CB1(-/-) mice had increased glucose stimulated insulin secretion. In mouse insulinoma cells, cannabinoids reduced GLP-1R-mediated intracellular CAMP accumulation and subsequent insulin secretion. Importantly, such effects were also evident in human islets, and were prevented by pharmacologic blockade of CB1. Collectively, these findings suggest a novel mechanism in which endocannabinoids are negative modulators of incretin-mediated insulin secretion. (C) 2015 Elsevier Ireland Ltd. All rights reserved.</P>
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Emotion Expressiveness and Knowledge in Preschool-Age Children: Age-Related Changes
Nana Shin,Lisa Krzysik,Brian E Vaughn 한국아동학회 2014 Child studies in Asia-Pacific context Vol.4 No.1
Emotion is a central feature of social interactions. In this study, we examined age-related changes in emotion expressiveness and emotion knowledge and how young children`s emotion expressiveness and knowledge were related. A total of 300 children attending a daycare center contributed data for the study. Observation and interview data relevant to measures of emotion expressiveness and knowledge were collected and analyzed. Both emotion knowledge and expressed positive affect increased with age. Older preschool children expressed positive affect more frequently than did younger preschoolers. Older preschool children also labeled, recognized, and provided plausible causes mores accurately than did younger preschool children. In addition, we tested whether children`s errors on the free labeling component conform to the structural model previously suggested by Bullock and Russell (1986) and found that preschool children were using systematic strategies for labeling emotion states. Relations between emotion expressiveness and emotion knowledge generally were not significant, suggesting that emotional competence is only gradually constructed by the child over the preschool years.
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Resveratrol Prevents β-Cell Dedifferentiation in Nonhuman Primates Given a High-Fat/High-Sugar Diet
Fiori, Jennifer L.,Shin, Yu-Kyong,Kim, Wook,Krzysik-Walker, Susan M.,Gonzá,lez-Mariscal, Isabel,Carlson, Olga D.,Sanghvi, Mitesh,Moaddel, Ruin,Farhang, Kathleen,Gadkaree, Shekhar K.,Doyle, Maire American Diabetes Association 2013 Diabetes Vol.62 No.10
<P>Eating a “Westernized” diet high in fat and sugar leads to weight gain and numerous health problems, including the development of type 2 diabetes mellitus (T2DM). Rodent studies have shown that resveratrol supplementation reduces blood glucose levels, preserves β-cells in islets of Langerhans, and improves insulin action. Although rodent models are helpful for understanding β-cell biology and certain aspects of T2DM pathology, they fail to reproduce the complexity of the human disease as well as that of nonhuman primates. Rhesus monkeys were fed a standard diet (SD), or a high-fat/high-sugar diet in combination with either placebo (HFS) or resveratrol (HFS+Resv) for 24 months, and pancreata were examined before overt dysglycemia occurred. Increased glucose-stimulated insulin secretion and insulin resistance occurred in both HFS and HFS+Resv diets compared with SD. Although islet size was unaffected, there was a significant decrease in β-cells and an increase in α-cells containing glucagon and glucagon-like peptide 1 with HFS diets. Islets from HFS+Resv monkeys were morphologically similar to SD. HFS diets also resulted in decreased expression of essential β-cell transcription factors forkhead box O1 (FOXO1), NKX6–1, NKX2–2, and <I>PDX1</I>, which did not occur with resveratrol supplementation. Similar changes were observed in human islets where the effects of resveratrol were mediated through Sirtuin 1. These findings have implications for the management of humans with insulin resistance, prediabetes, and diabetes.</P>
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