http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Kornilov, Polina,Peretz, Asher,Lee, Yoonji,Son, Karam,Lee, Jin Hee,Refaeli, Bosmat,Roz, Netta,Rehavi, Moshe,Choi, Sun,Attali, Bernard The Federation of American Societies for Experimen 2014 The FASEB Journal Vol.28 No.6
<P>Some of the fascinating features of voltage-sensing domains (VSDs) in voltage-gated cation channels (VGCCs) are their modular nature and adaptability. Here we examined the VSD sensitivity of different VGCCs to 2 structurally related nontoxin gating modifiers, NH17 and NH29, which stabilize K<SUB>v</SUB>7.2 potassium channels in the closed and open states, respectively. The effects of NH17 and NH29 were examined in Chinese hamster ovary cells transfected with transient receptor potential vanilloid 1 (TRPV1) or K<SUB>v</SUB>7.2 channels, as well as in dorsal root ganglia neurons, using the whole-cell patch-clamp technique. NH17 and NH29 exert opposite effects on TRPV1 channels, operating, respectively, as an activator and a blocker of TRPV1 currents (EC<SUB>50</SUB> and IC<SUB>50</SUB> values ranging from 4 to 40 μM). Combined mutagenesis, electrophysiology, structural homology modeling, molecular docking, and molecular dynamics simulation indicate that both compounds target the VSDs of TRPV1 channels, which, like vanilloids, are involved in π-π stacking, H-bonding, and hydrophobic interactions. Reflecting their promiscuity, the drugs also affect the lone VSD proton channel mVSOP. Thus, the same gating modifier can promiscuously interact with different VGCCs, and subtle differences at the VSD-ligand interface will dictate whether the gating modifier stabilizes channels in either the closed or the open state.—Kornilov, P., Peretz, A., Lee, Y., Son, K., Lee, J. H., Refaeli, B., Roz, N., Rehavi, M., Choi, S., Attali, B. Promiscuous gating modifiers target the voltage sensor of K<SUB>v</SUB>7.2, TRPV1, and H<SUB>v</SUB>1 cation channels.</P>
^(235)U Prompt Fission Neutron Spectra-Experimental Mistakes or Lack of Understanding?
N. Kornilov 한국물리학회 2011 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.59 No.23
The isotope ^(235)U is the most important one for nuclear energy production. This explains the particular interest in measurements and evaluation of ^(235)U(n,f) neutron emission data. The Prompt Fission Neutron Spectrum (PFNS) from the ^(235)U(n,f) reaction has been investigated in many experiments at different incident neutron energies from thermal to the fast region. These efforts were motivated by a persistent conflict between microscopic and macroscopic (integral average cross section and K_(eff) experiments) data which still exists today. Can we explain this difference due to experimental mistakes or we should assume unknown physical effect? The experimental facts which confirm that problem exist, some suggestions for future investigations are discussing in the presentation.
Evaluation of the Experimental np-Angular Distribution at 14.1 MeV Neutron Energy
N. V. Kornilov,T. Massey,S. Grimes 한국물리학회 2011 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.59 No.23
The total cross section and angular distribution of the (n,p) scattering reaction is an object for detailed experimental and theoretical investigations as a primary standard. In spite of many years efforts these data, in particular the angular distribution are not known with required accuracy. We analyzed available experimental data at ∼14 MeV and concluded that the big data spread is connected mainly with data normalization. We renormalize the original data using the following procedure. All data sets were fit by different polynomial expansions. The data of independent experiments were normalized to reach minimum χ^2. The beginning value was χ^2 = 1.47 and final value χ^2 = 0.41. The data corrections were <5%. The final result is insensitive to the order of polynomial expansion. The final χ^2 of 0.41 indicates that we have reduced systematic errors in the data sets, so we have reduced the error bars by a factor of 1.6. ENDF/B-7 data are in reasonable agreement with evaluated experimental data. But some problem became more visible - it seems that experimental data require stronger angular asymmetry.