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- 저자 : Peretz, Asher (검색결과 2 건)
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Kornilov, Polina,Peretz, Asher,Lee, Yoonji,Son, Karam,Lee, Jin Hee,Refaeli, Bosmat,Roz, Netta,Rehavi, Moshe,Choi, Sun,Attali, Bernard The Federation of American Societies for Experimen 2014 The FASEB Journal Vol.28 No.6
<P>Some of the fascinating features of voltage-sensing domains (VSDs) in voltage-gated cation channels (VGCCs) are their modular nature and adaptability. Here we examined the VSD sensitivity of different VGCCs to 2 structurally related nontoxin gating modifiers, NH17 and NH29, which stabilize K<SUB>v</SUB>7.2 potassium channels in the closed and open states, respectively. The effects of NH17 and NH29 were examined in Chinese hamster ovary cells transfected with transient receptor potential vanilloid 1 (TRPV1) or K<SUB>v</SUB>7.2 channels, as well as in dorsal root ganglia neurons, using the whole-cell patch-clamp technique. NH17 and NH29 exert opposite effects on TRPV1 channels, operating, respectively, as an activator and a blocker of TRPV1 currents (EC<SUB>50</SUB> and IC<SUB>50</SUB> values ranging from 4 to 40 μM). Combined mutagenesis, electrophysiology, structural homology modeling, molecular docking, and molecular dynamics simulation indicate that both compounds target the VSDs of TRPV1 channels, which, like vanilloids, are involved in π-π stacking, H-bonding, and hydrophobic interactions. Reflecting their promiscuity, the drugs also affect the lone VSD proton channel mVSOP. Thus, the same gating modifier can promiscuously interact with different VGCCs, and subtle differences at the VSD-ligand interface will dictate whether the gating modifier stabilizes channels in either the closed or the open state.—Kornilov, P., Peretz, A., Lee, Y., Son, K., Lee, J. H., Refaeli, B., Roz, N., Rehavi, M., Choi, S., Attali, B. Promiscuous gating modifiers target the voltage sensor of K<SUB>v</SUB>7.2, TRPV1, and H<SUB>v</SUB>1 cation channels.</P>
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Eli Abramov,Mor Mordechai Peretz,Ilya Zeltser 전력전자학회 2019 ICPE(ISPE)논문집 Vol.2019 No.5
This study delineates the conditions for softswitching in capacitively-coupled resonant converters that are compensated with LCLC matching networks. Such converters’ setups are extremely popular in wireless capacitive power transfer(CPT) technology. The detailed analysis explores the intricate relationships between the parameters, operating conditions, and transfer characteristics. It reveals that by design of the compensation networks’ parameters according to the highest expected coupling capacitance, then zero-voltage switching (ZVS) conditions are achieved over the entire operation range. The results of the analysis further outline the necessary conditions for zero-current switching (ZCS) at turn off. Consequently, the system maintains soft-switching both at turn on and turn off, for all switches. This provides a significant potential enhancement of the power transfer and processing efficiency, in particular for applications of wireless energy where the operating frequency is very high. The theoretical analysis and predictions have been verified by simulations and experimentally. The simulation platform incorporates a simple and flexible cross-coupled model, also developed in this study, which is used to evaluate the results under various conditions. The experiments have been carried out on a LCLC capacitive-based WPT prototype operated in the MHz range, and examined through several air-gaps up to 120 mm. An excellent agreement has been obtained between the theoretical work, simulations and the experimental evidence.
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