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Effectiveness of music therapy on the activation level of cerebral function
Katsutoshi Tadokoro,Koh Inoue,Keisuke Suzuki 대한인간공학회 2012 대한인간공학회 학술대회논문집 Vol.2012 No.5
The effectiveness of the musical therapy on cerebral function and cerebral blood flow is not clearly investigated. In this research, the relation between how to enjoy the music and activity level of cerebral function when listening to music or singing music was investigated. Based on the investigation results, the optimal presentation method of the music effecting on the activity level of the brain was proposed. In this study, the activity level of cerebral function was quantified in terms of the fluctuation of oxygenated hemoglobin (oxyHb). The fluctuation of the oxyHb and the RRI of heart rate were observed during each experiment. The Cardiac Sympathetic Index (CSI) of the sympathetic nerve and the Cardiac Vagal Index (CVI) of the parasympathetic nerve were used for the investigation. It was observed that making the level of CVI higher by listening to music after making the level of CSI higher by singing music is effective for increasing the level of oxyHb.
Kim, Eun-Young,Inoue, Naomi,Koh, Dong-Hee,Iwata, Hisato Elsevier 2019 Ecotoxicology and environmental safety Vol.171 No.-
<P><B>Abstract</B></P> <P>To understand the role of aryl hydrocarbon receptor (AHR) isoforms in avian species, we investigated the functional characteristics of two AHR isoforms (designated as <I>jc</I>AHR1 and <I>jc</I>AHR2) of the jungle crow (<I>Corvus macrorhynchos</I>). Two amino acid residues corresponding to Ile<SUP>324</SUP> and Ser<SUP>380</SUP> (high sensitive type) in chicken AHR1 that are known to determine dioxin sensitivity were Ile<SUP>325</SUP> and Ala<SUP>381</SUP> (moderate sensitive type) in <I>jc</I>AHR1 and Val<SUP>306</SUP> and Ala<SUP>362</SUP> (low sensitive type) in <I>jc</I>AHR2. The quantitative comparison of the two <I>jc</I>AHR mRNA expression levels in a Tokyo jungle crow population showed that <I>jc</I>AHR2 accounted for 92.4% in the liver, while <I>jc</I>AHR1 accounted for only 7.6%. Both <I>in vitro</I>-expressed <I>jc</I>AHR1 and <I>jc</I>AHR2 proteins exhibited a specific binding to [<SUP>3</SUP>H]-labeled 2,3,7,8-tetrachlorodibenzo-<I>p</I>-dioxin (TCDD). Transactivation potencies for <I>jc</I>AHR1 and <I>jc</I>AHR2 in <I>in vitro</I> reporter gene assays were measured in <I>jc</I>AHR-expressed cells exposed to 16 dioxins and related compounds (DRCs). Both <I>jc</I>AHR1 and <I>jc</I>AHR2 were activated in a congener- and an isoform-specific manner. EC<SUB>50</SUB> value of TCDD for <I>jc</I>AHR2 (0.61 nM) was six-fold higher than that for <I>jc</I>AHR1 (0.098 nM), but <I>jc</I>AHR2 had higher transactivation efficacy than <I>jc</I>AHR1 in terms of the magnitude of response. The high transactivation efficacy of <I>jc</I>AHR2 in DRCs is in contrast to that of AHR2s in other avian species with low transactivation efficacy. Molecular docking simulations of TCDD with <I>in silico jc</I>AHR1 and <I>jc</I>AHR2 homology models showed that the two sensitivity-decisive amino acids indirectly controlled TCDD-binding modes through their surrounding amino acids. Deletion assays of <I>jc</I>AHR2 revealed that 736–805 amino acid residues in the C-terminal region were critical for its transactivation. We suggest that <I>jc</I>AHR2 plays a critical role in regulating the AHR signaling pathway, at least in its highly expressed organs.</P> <P><B>Highlights</B></P> <P> <UL> <LI> To understand the role of aryl hydrocarbon receptor (AHR) isoforms in avian species, we investigated the functional characteristics of two AHR isoforms (designated as <I>jc</I>AHR1 and <I>jc</I>AHR2) of the jungle crow (<I>Corvus macrorhynchos</I>). </LI> <LI> The quantitative comparison of the two <I>jc</I>AHR mRNA expression levels in a Tokyo jungle crow population showed that <I>jc</I>AHR2 accounted for 92.4% in the liver, while <I>jc</I>AHR1 accounted for only 7.6%. </LI> <LI> Apart from previous studies indicating that AHR1 is a major player that determines dioxin susceptibility in avian species, we clarify here that AHR2 in the jungle crow plays a critical role in AHR signaling, at least in the liver, due to its higher mRNA expression levels and abilities of TCDD binding and transactivation. </LI> </UL> </P>
Kim, Jae-Jung,Park, Young-Mi,Baik, Kyu-Heum,Choi, Hye-Yeon,Yang, Gap-Seok,Koh, InSong,Hwang, Jung-Ah,Lee, Jieun,Lee, Yeon-Su,Rhee, Hwanseok,Kwon, Tae Soo,Han, Bok-Ghee,Heath, Karen E,Inoue, Hiroshi,Yo Springer-Verlag 2012 HUMAN GENETICS Vol.131 No.3
<P>Height is a highly heritable trait that involves multiple genetic loci. To identify causal variants that influence stature, we sequenced whole exomes of four children with idiopathic short stature. Ninety-five nonsynonymous single-nucleotide polymorphisms (nsSNPs) were selected as potential candidate variants. We performed association analysis in 740 cohort individuals and identified 11 nsSNPs in 10 loci (DIS3L2, ZBTB38, FAM154A, PTCH1, TSSC4, KIF18A, GPR133, ACAN, FAM59A, and NINL) associated with adult height (P < 0.05), including five novel loci. Of these, two nsSNPs (TSSC4 and KIF18A loci) were significant at P < 0.05 in the replication study (n = 1,000) and five (ZBTB38, FAM154A, TSSC4, KIF18A, and FAM59A loci) were significant at P < 0.01 in the combined analysis (n = 1,740). Together, the five nsSNPs accounted for approximately 2.5% of the height variation. This study demonstrated the utility of next-generation sequencing in identifying genetic variants and loci associated with complex traits.</P>