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Kim, Youn-Young,Kang, Kwi-Man,Chung, Sung-Hyun The Pharmaceutical Society of Korea 2002 Archives of Pharmacal Research Vol.25 No.6
We investigated the long term effects of Sopungsungi-won (SP), a Korean traditional formula used for senile constipation and diabetes mellitus, on the development of diabetic nephropathy (DN) in Zucker diabetic fatty (ZDF) rats. ZDF rats were fed regular laboratory chow mixed with SP or rosiglitazone (RSG) for an 8-week period. Kidney hypertrophy was developed with increasing plasma glucose level, and glomerular hypertrophy was improved by 22% and 45% in SP- and RSG-treated rats, respectively. Urinary glucose and albumin excretions were also significantly lower in SP-treated rats than in ZDF control rats. Activation of the mitogen-activated protein kinase (MAPK)-transforming growth factor ${\beta}1$ (TGF ${\beta}1$)-fibronectin pathway in kidney, responsible for glomerular dysfunction, was markedly blunted by SP treatment in a dose dependent manner. Our findings, for the first time, provide strong evidence that long-term administration of SP formula prevents the development and progression of DN in ZDF rats. Human trials are needed to confirm these experimental results.
An 155.52Mbps Physical Layer Processor for ATM Applications
Kim,Sung Do,Jung,Hee Bum,Kim,Kwi Dong,Chai,Sang Hoon,Song,Won Chul,Kim,Kyung Soo 대한전자공학회 1997 ICVC : International Conference on VLSI and CAD Vol.5 No.1
An analog/digital mixed-signal physical layer processing IC for ATM UNI/NNI interface is presented. This ASIC consists of three modules, which are a receiver, a transmitter, and a SDH processor. In the design of receiver and transmitter modules analog full custom PLL circuits are used. The SDH processor is designed with digital standard cell libraries. The chip has been implemented using 0.8㎛ digital CMOS process technology. The experimental result shows power consumption of 950mW at 155.52Mbps.
Heart-shaped pedunculated lipofibroma of the coccygeal area in a neonate
Sung-Min Hong,Soo-Hong Kim,Sung-Eun Jung,Kwi-Won Park,Hyun-Young Kim 대한외과학회 2013 Annals of Surgical Treatment and Research(ASRT) Vol.84 No.1
Pedunculated lipofibroma is a rare benign hamartomatous condition that is characterized by ectopic adipose tissue in the dermis and a solitary form of nevus lipomatosus cutaneous superficialis. We describe here a neonate with congenital pedunculated lipofibroma. The lesion was removed by simple excision.
Kim, Hyoung Rae,Hong, Yeon Sik,Park, Sung-Hwan,Ju, Ji Hyeon,Kang, Kwi Young BioMed Central 2018 Arthritis research & therapy Vol.20 No.-
<P><B>Background</B></P><P>This study aimed to investigate whether the presence of low bone mineral density (BMD) in patients with axial spondyloarthritis (axSpA) predicts formation of new syndesmophytes over 2 years.</P><P><B>Methods</B></P><P>One hundred and nineteen patients fulfilling the imaging arm of the Assessment of SpondyloArthritis International Society axSpA criteria were enrolled. All patients were under 50 years of age. The modified Stoke Ankylosing Spondylitis Spinal Score (mSASSS) was assessed by two trained readers blinded to the patients’ data. BMD (lumbar spine, femoral neck or total hip) at baseline was assessed using dual-energy absorptiometry. Low BMD was defined as <I>Z</I> score ≤ − 2.0. Spinal radiographic progression was defined as worsening of the mSASSS by ≥ 2 points over 2 years. Logistic regression analyses were performed to identify predictors associated with development of new syndesmophytes and spinal radiographic progression.</P><P><B>Results</B></P><P>At baseline, 19 (16%) patients had low BMD. New syndesmophytes had developed in 22 (21%) patients at 2-year follow-up. New syndesmophyte formation after 2 years occurred more in patients with low BMD than in those with normal BMD (<I>p</I> = 0.047). In the multivariable analysis, current smoking, existing syndesmophytes and low BMD at baseline were associated with spinal radiographic progression (OR (95% CI) 3.0 (1.1, 7.7), 4.6 (1.8, 11.8) and 3.6 (1.2, 11.2), respectively). The presence of syndesmophytes at baseline and low BMD were predictors of new syndesmophytes over the following 2 years (OR (95% CI) 5.5 (2.0, 15.2) and 3.6 (1.1, 11.8), respectively).</P><P><B>Conclusions</B></P><P>Low BMD and existing syndesmophytes at baseline were independently associated with the development of new syndesmophytes in young axSpA patients.</P>
X-ray Irradiation Induced Damage in MOS Structures and It's Effect on Oxide Reliability
Kim, Shi Ho,Lee, Ho Jun,Han, Chul Hi,Lee, Kwy Ro,Choi, Sang Soo,Jeon, Young Jin,Fabrizio, Enzo Di,Gentili, Massimo 대한전자공학회 1993 ICVC : International Conference on VLSI and CAD Vol.3 No.1
The effects of X-ray induced damage on long-term reliability of MOS structures have been investigated. The gate leakage at low electric field during measurement of Flow-Nordheim tunneling current increases after X-ray irradiation. which is explained by interface trap-assisted tunneling mechanism. This leakage component is completely eliminated by forming gas annealing at 45℃, The long-term reliability of MOS gate oxide, is significantly affected by the residual damages in the oxide every after annealing. In MOS structures, charge to breakdown(Qbd) is reduced about 15% from the unirradiated device. The major mechanisms responsible for reduction of Qbd in irradiated device arc enhanced electron trapping into tile neutral traps and effective thinning of gate oxide by additional defects. Degradation of reliability in irradiated MOS structure limits the applications of X-ray lithography to the devices which required low gate leakage current and high long-term stability sucn as EEPROM's and Flash Memory's.
Kim, Ga-Hyun,Kim, Il-Shin,Park, Sang-Won,Lee, Kwangmin,Yun, Kwi-Dug,Kim, Hyun-Seung,Oh, Gye-Jeong,Ji, Min-Kyung,Lim, Hyun-Pil American Scientific Publishers 2016 Journal of Nanoscience and Nanotechnology Vol.16 No.2
<P>This study examined the effect of the immobilization of the Gly-Arg-Gly-Asp-Ser (GRGDS) peptide on titanium dioxide (TiO2) nanotube via chemical grafting on osteoblast-like cell (MG-63) viability and differentiation. The specimens were divided into two groups; TiO2 nanotubes and GRGDS-immobilized TiO2 nanotubes. The surface characteristics of GRGDS-immobilized TiO2 nanotubes were observed by using X-ray photoelectron spectroscopy (XPS) and a field emission scanning electron microscope (FE-SEM). The morphology of cells on specimens was observed by FE-SEM after 2 hr and 24 hr. The level of cell viability was investigated via a tetrazolium (XTT) assay after 2 and 4 days. Alkaline phosphatase (ALP) activity was evaluated to measure the cell differentiation after 4 and 7 days. The presence of nitrogen up-regulation or C=O carbons confirmed that TiO2 nanotubes were immobilized with GRGDS peptides. Cell adhesion was enhanced on the GRGDS-immobilized TiO2 nanotubes compared to TiO2 nanotubes. Furthermore, significantly increased cell spreading and proliferation were observed with the cells grown on GRGDS-immobilized TiO2 nanotubes (P < .05). However, there was no significant difference in ALP activity between GRGDS-immobilized TiO2 nanotubes and TiO2 nanotubes. These results suggest that the GRGDS-immobilized TiO2 nanotubes might be effective in improving the osseointegration of dental implants.</P>
Enhancement of cycle performance of Li–S batteries by redistribution of sulfur
Kim, Kwi Ryong,Yu, Seung-Ho,Sung, Yung-Eun The Royal Society of Chemistry 2016 Chemical communications Vol.52 No.6
<P>A practically available strategy is employed to improve the cycle life of lithium-sulfur batteries. The simple process of activation cycling at the polysulfide dissolution region leads to the partial dissolution of polysulfides and the redistribution of sulfur on the electrode. After 50 cycles, the modified activation-cycled sulfur cathode exhibits a capacity that is roughly double that of a cathode without activation cycling.</P>