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Keloid와 Hypertrophic Scar ( 비후성반흔 )의 형태학적 관찰
김정숙,유재덕,Kim, Chung-Soak,Lew, Jae-Duk 한국현미경학회 1973 Applied microscopy Vol.3 No.1
Introduction. The human cutaneous scars manifest themselves many ways in different types according to the factors such as the age, sex, race of the patient as well as the location,. kind and heal ing process of the wound. Among the scars it is quiet difficult to verify the clinical course of the hypertrophic or keloidal scars from the true keloids. However, clinical observations indicate that stress, either mechanical or in the forms of chronic infections, can induce a functional change in the fibroblasts causing an excessive production of collagenous matrix. In this study, we preliminary attempt to justify any difference of the cellular structure between keloids and hypertrophic scars by using electron microscope. Material and Methods. A total of 23 cases: 2 scars, 2 hypertrophic scars and 19 keloids are examined. Immediately, the biopsy tissue was fixed in 10% neutral formalin and 4% glutaraldehyde solution in phosphate buffer for 4 hours, post fixed in 1 % osmium tetraoxide for two hours, dehydrated with graded alcohol, and embedded in Epon 812. Thick sections were stained with hematoxylin eosin, periodic acid-Schiff(PAS) and Van Gieson stain. Thin sections were cut and uranyle acetate, lead citratestain and examined with the electron microscope. Result. The morphologic features of keloid showed thick, homogenously eosinophilic bands of collagen and numberous large active fibroblasts. The hypertrophic scar and soft scar are more cellular than keloid and composed thinner collagenous fiber. For this paper in the etiology of keloids can not as be defined, but and interesting keloidal tissue fibroblast showed irregular nucleus with irregular shape dense bodies and fibril materials contained in to the cytoplasm.
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권태정,김정숙,문영명,Kwon Tae-Jung,Kim Chung-Soak,Moon Young-Myung 한국현미경학회 1981 Applied microscopy Vol.11 No.1
Gastric xanthoma which is not a true neoplasm and clinically insignificant consists of the small yellowish lesion of the gastric mucosa, frequently of multiple occurrence. Histologically the lesion shows chronic superficial gastritis with intestinal metaplasia and occasional collections of foam cells within the lamina propria. Electron microscopically. the xanthoma, cells are composed of. lipid-laden histiocytes with. many autophagocytic Iysosomes surrounding the cytoplasmic lipid vacuoles. Many residual bodies are also noted. The pathogenesis of the gastric xanthoma is obscure, however it is thought that a previous focal lesion of the gastric mucosa may have been a factor. One case of gastric xanthoma is reported here and a brief review of literature is also made.
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한경자(Han Kyung Ja),이은옥(Lee Eun Ok),김매자(Kim Mae Ja),하양숙(Hah Yang Soak),박영숙(Park Young Soak),송미순(Song Mi Soon),정재원(Chung ChaeWeon),박성희(Park Sunghee),문미혜(Moon Mi Hye) 대한종양간호학회 2004 Asian Oncology Nursing Vol.4 No.2
Purpose: To exarmne Informational needs of cancer patients receiving chemotherapy Methods: A cross<br/> sectional survey design was utilized The sample was 198 cancer patients receiving chemotherapy for a diagnosis of stomach or lung cancer at a university hospital A modified version of Toronto Informational Needs Questionnaire was applied Results Subjects reported highest Informational needs In prognosis dimension. followed by the treatment dimension Including side effects and alternativetherapy Information about medical tests and follow-up care after the treatment was also in great need Dimensions of support for pattents/famlly and sexuahty were low in need The degree of informational needs was negatively correlated with patient's age and number of children Differences were found in informational needs according to the educational level employment status. and gender of the patIents. while diagnosis and treatment options did not make differences in informational needs. Conclusion: Health care professionals need to perceive informational needs of cancer patients receiving chemotherapy. and to provide them with information especially in the area of prognosis and treatment Informational intervention would be effective when it si given with consideration of patien's charactenstics
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