고혈압 치료에 있어 알파차단제의 효과

Khoury, Alexander F.,Kaplan, Norman M.,吳秉熙 대한의학협회 1992 대한의학협회지 Vol.35 No.2

Accelerating the Execution of Matrix Languages on the Cell Broadband Engine Architecture

Khoury, R,Burgstaller, B,Scholz, B IEEE 2011 IEEE transactions on parallel and distributed syst Vol.22 No.1

<P>Matrix languages, including MATLAB and Octave, are established standards for applications in science and engineering. They provide interactive programming environments that are easy to use due to their script languages with matrix data types. Current implementations of matrix languages do not fully utilize high-performance, special-purpose chip architectures, such as the IBM PowerXCell processor (Cell). We present a new framework that extends Octave to harvest the computational power of the Cell. With this framework, the programmer is alleviated of the burden of introducing explicit notions of parallelism. Instead, the programmer uses a new matrix data type to execute matrix operations in parallel on the synergistic processing elements (SPEs) of the Cell. We employ lazy evaluation semantics for our new matrix data type to obtain execution traces of matrix operations. Traces are converted to data dependence graphs; operations in the data dependence graph are lowered (split into submatrices), scheduled and executed on the SPEs. Thereby, we exploit 1) data parallelism, 2) instruction level parallelism, 3) pipeline parallelism, and 4) task parallelism of matrix language programs. We conducted extensive experiments to show the validity of our approach. Our Cell-based implementation achieves speedups of up to a factor of 12 over code run on recent Intel Core2 Quad processors.</P>

Dasatinib treatment for Philadelphia chromosome-positive leukemias : Practical considerations

Khoury, Hanna Jean,Guilhot, Franç,ois,Hughes, Timothy P.,Kim, Dong-Wook,Cortes, Jorge E. Wiley Subscription Services, Inc., A Wiley Company 2009 Cancer Vol.115 No.7

<P>Dasatinib is a highly potent Bcr-Abl inhibitor that is approved for the treatment of imatinib-resistant or -intolerant chronic myeloid leukemia (CML) and Philadelphia chromosome-positive acute lymphoblastic leukemia. Across a series of phase 2 and 3 trials, dasatinib was associated with durable treatment responses in all phases of the disease and was well tolerated. For this article, the authors reviewed available information on specific side effects associated with the use of dasatinib. On the basis of more than 2 years' experience of dasatinib treatment during clinical trials, they provide practical recommendations for side-effect management. Cancer 2009. © 2009 American Cancer Society.</P>

Bosutinib is active in chronic phase chronic myeloid leukemia after imatinib and dasatinib and/or nilotinib therapy failure

Khoury, H. Jean,Cortes, Jorge E.,Kantarjian, Hagop M.,Gambacorti-Passerini, Carlo,Baccarani, Michele,Kim, Dong-Wook,Zaritskey, Andrey,Countouriotis, Athena,Besson, Nadine,Leip, Eric,Kelly, Virginia,Br American Society of Hematology 2012 Blood Vol.119 No.15

<P>Bosutinib, a dual Src/Abl tyrosine kinase inhibitor (TKI), has shown potent activity against chronic myeloid leukemia (CML). This phase 1/2 study evaluated the efficacy and safety of once-daily bosutinib 500 mg in leukemia patients after resistance/intolerance to imatinib. The current analysis included 118 patients with chronic-phase CML who had been pretreated with imatinib followed by dasatinib and/or nilotinib, with a median follow-up of 28.5 months. In this subpopulation, major cytogenetic response was attained by 32% of patients; complete cytogenetic response was attained by 24%, including in one of 3 patients treated with 3 prior TKIs. Complete hematologic response was achieved/maintained in 73% of patients. On-treatment transformation to accelerated/blast phase occurred in 5 patients. At 2 years, Kaplan-Meier-estimated progression-free survival was 73% and estimated overall survival was 83%. Responses were seen across Bcr-Abl mutations, including those associated with dasatinib and nilotinib resistance, except T315I. Bosutinib had an acceptable safety profile; treatment-emergent adverse events were primarily manageable grade 1/2 gastrointestinal events and rash. Grade 3/4 nonhematologic adverse events (> 2% of patients) included diarrhea (8%) and rash (4%). Bosutinib may offer a new treatment option for patients with chronic-phase CML after treatment with multiple TKIs. This trial was registered at www.clinicaltrials.gov as NCT00261846.</P>

Phenotypic and Cell Wall Proteomic Characterization of a DDR48 Mutant Candida albicans Strain

( Pamela El Khoury ),( Carell Salameh ),( Samer Younes ),( Andy Awad ),( Yana Said ),( Roy A. Khalaf ) 한국미생물 · 생명공학회 2019 Journal of microbiology and biotechnology Vol.29 No.11

Candida albicans is an opportunistic fungus possessing multiple virulence factors controlling pathogenicity. Cell wall proteins are the most important among these factors, being the first elements contacting the host. Ddr48 is a cell wall protein consisting of 212 amino acids. A DDR48 haploinsufficient mutant strain was previously found necessary for proper oxidative stress response and drug resistance. In this study, we aimed to further elucidate the role of Ddr48 by performing additional phenotypic characterization assays. A combinatory proteomic and bioinformatics approach was also undertaken to determine differentially expressed cell wall proteins. Results showed that the mutant strain exhibited a 10% decrease in adhesion mirrored by a 20% decrease in biofilm formation, and slight sensitivity to menadione, diamide, and SDS. Both strains showed similar hyphae formation, virulence, temperature tolerance, and calcofluor white and Congo red sensitivities. Furthermore, a total of 8 and 10 proteins were identified exclusively in the wild-type strain grown under filamentous and nonfilamentous conditions respectively. Results included proteins responsible for superoxide stress resistance (Sod4 and Sod6), adhesion (Als3, Hyr4, Pmt1, and Utr2), biofilm formation (Hsp90, Ece1, Rim9, Ipp1, and Pra1) and cell wall integrity (Utr2 and Pga4). The lack of detection of these proteins in the mutant strain correlates with the observed phenotypes.

CAN THE PHOENIX STILL RISE? TRAUMATIC EFFECT OF BEIRUT PORT EXPLOSION ON LEBANESE PEOPLE’S EXPERIENCES

Myriam El Khoury Malhame,Dunia Harajli,Rafal Ohme,Dorota Reykowska,Malgorzata Jakubowska 글로벌지식마케팅경영학회 2023 Global Marketing Conference Vol.2023 No.07

Mental distress has been consistently reported to be highly prevalent after collective traumas, alongside physical and personal damages. When left untreated, these will worsen survivors’ ability to function. Research also points to unmet needs, related to job security and a sense of belonging. Our study aims to identify a clustered-dimensional approach to people’s experiences after a massive urban violence apart from traditional categorical psychopathological assessments. This cross-sectional internet-based study included 1305 Lebanese adults, 4 months after the apocalyptic Beirut Port explosion. Emotions, attitudes and needs were assessed using iCode software, measuring explicit answers and implicit reaction time. First and foremost, explicit responses revealed alarming levels of distress (75-80%). Latent class analysis further differentiated three groups on seven different dimensions derived from principal component analysis. People who experienced the most intense emotional distress and intrusive thoughts had higher country dissatisfaction and job worries. Faith and community resilience buffered the negative emotionality of those affected in spite of avoidance and intrusion. The last group was less distressed by the trauma with a marked sense of community and an overall reduced country and job dissatisfactions. These findings suggest that integrating implicit responses helps cluster people’s experiences after a collective trauma above and beyond single demographic criteria as vulnerability to mass violence is quite variable within seemingly homogenous samples. They also provide insight onto hard-wired attitudes and needs post-trauma. It mostly taps into multi-factorial individual vulnerabilities and protective factors to better refine targeted interventions for at-risk subpopulation outreach and foster resilience in unstable environments.

Enforcing Security in Smart Homes using Security Patterns

Paul El Khoury,Pierre Busnel,Sylvain Giroux,Keqin Li 보안공학연구지원센터 2009 International Journal of Smart Home Vol.3 No.2

Providing context-dependent security services is an important challenge in ambient intelligence. The complexity and the unbounded nature of such systems make it difficult for software developers to integrate security solutions. In order to solve this problem, in this paper we discuss and address multifold security challenges involved in the implementation of remote healthcare in smart homes using the security patterns approach. First the security challenges are derived from a real-world, industrially relevant scenario. Then it is shown how validated security techniques and mechanisms providing certain security properties can be captured and implemented in security patterns. Next security patterns are applied to satisfy security requirements in the smart home healthcare scenario. The process is exemplified thanks to a running prototype implementing the scenario.

Readiness of Translation Graduates for the Job in the Jordanian Market: The Employers` Perspective

( Ogareet Yacoub Khoury ) 이화여자대학교 통역번역연구소 2017 T&I review Vol.7 No.-

This is an empirical study that surveys the employers at the translation industry in Jordan on the competences and skills required the most in the market versus what they lack in the inexperienced translation graduates. Forty two employers from different translation service providers in the capital city, Amman are surveyed on their perceptions of translation competence. The PACTE competence model (2000, 2003, 2005, 2009, 2011) is used as a guiding model for the study. The data collection tool employed is a closed-ended Likert type questionnaire on a four-point scale. The purpose of the study is to reveal the demands of the market in relation to the status quo of the translator training programs at the Jordanian universities. Understanding what the programs offer, their pedagogical methodology and strategy and the extent to which they are market-oriented unveils any existing weaknesses and paves the way for implementing corrective actions. The results reveal that there is a gap between what is required by the employers at the translation service providers and the competence of the inexperienced graduates -from the perspective of the employers. The significance of the study lies in its reliance on empirical evidence in probing the requirements of the employers versus the actual competence of the graduates; a research area which has been left unexplored in Jordan.

Dietary Application for the Management of Patients with Hemodialysis: A Formative Development Study

Cosette Fakih El Khoury,Mirey Karavetian,Ruud J.G. Halfens,Rik Crutzen,Dayana El Chaar,Jos M. G. A. Schols 대한의료정보학회 2019 Healthcare Informatics Research Vol.25 No.4

Objectives: To describe the step-by-step person-centered, theory-based development of the KELA.AE app for Arabic speaking hemodialysis patients. Methods: A step-by-step person-driven theory-based approach was conducted to develop a self-monitoring and educational dietary app for hemodialysis patients. The development follows the Integration, Design, Assessment, and Sharing (IDEAS) framework. Qualitative, semi-structured interviews with 6 hemodialysis patients and 6 healthcare practitioners (dietitians and nephrologists) were performed to assess the need for an app, the willingness to use an app, and features desired in an app. Results: The KELA.AE app, which includes a self-monitoring feature, CKD-friendly recipes, and a theory-based, evidence-based educational feature was developed. Qualitative analysis of interviews revealed two predominant themes from patient interviews ‘Experience with the diet’, ‘App evaluation’, and one theme from interviews with healthcare practitioners ‘App evaluation’. Patients expressed frustration with current accessibility of dietary information along with the need for educational materials in the app. The review of the KELA.AE prototype was positive overall, and patients reported a willingness to use the app. Healthcare practitioners considered the app accurate, simple, and culturally sensitive but expressed concerns about app misuse and the replacement of healthcare practitioners. Conclusions: The KELA.AE app was found to be satisfactory and supportive of the participants’ needs. Changes were made to the app as suggested during the interviews.

Laparoscopic cystectomy for pancreatic echinococcosis

Ashraf Imam,Tawfik Khoury,Dani Weis,Harbi Khalayleh,Muhammad Adeleh,Abed Khalaileh 한국간담췌외과학회 2019 Annals of hepato-biliary-pancreatic surgery Vol.23 No.1

Cystic echinococcosis (CE) is a widely endemic helminthic disease caused by infection with the Echinococcus granulosus tapeworm. Following ingestion of eggs, hydatid cysts develop, most frequently in the liver and lungs, but occasionally in other organs. Infection of the pancreas by hydatid cysts is very rare, even in endemic areas. Most cases of pancreatic hydatid cysts reported in the literature were treated surgically using traditional open laparotomy. There are only few case reports describing laparoscopic treatment for this disease. Herein, we report on an eighteen-year-old female patient who was referred to our institution with a hydated pancreatic tail cyst. After a course of treatment with Albendazole, we successfully performed laparoscopic splenic-sparing distal pancreatectomy to remove the cyst with an uneventful intra- and post-operative course.