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RISS 인기검색어
- 검색키워드
- 저자 : Khaled Saad (검색결과 5 건)
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Khaled Saad,Azza A. Eltayeb,Ismail L. Mohamad,Abdulrahman A. Al-Atram,Yasser Elserogy,Geir Bjørklund,Amira A. El-Houfey,Bubba Nicholson 대한정신약물학회 2015 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.13 No.2
Objective: There is growing evidence for a gut-brain connection associated with autism spectrum disorders (ASDs). This suggests a potential benefit from introduced digestive enzymes for children with ASD. Methods: We performed a double-blind, randomized clinical trial on 101 children with ASD (82 boys and 19 girls) aged from 3 to 9 years. ASD patients were diagnosed according to the Diagnostic and Statistical Manual of Mental Disorders 4th edition, text revision (DSM-IV-TR) diagnostic criteria. Structured interviews of at least one hour each both with the parents and the child were performed. Later on, another two hours-session was conducted applying the Childhood Autism Rating Scale (CARS). ASD patients were randomized to receive digestive enzymes or placebo. Results: The ASD group receiving digestive enzyme therapy for 3 months had significant improvement in emotional response, general impression autistic score, general behavior and gastrointestinal symptoms. Our study demonstrated the usefulness of digestive enzyme in our population of ASD patients. Conclusion: Digestive enzymes are inexpensive, readily available, have an excellent safety profile, and have mildly beneficial effects in ASD patients. Depending on the parameter measured in our study, we propose digestive enzymes for managing symptoms of ASD. Digestive enzyme therapy may be a possible option in treatment protocols for ASD in the future.
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Improving the brittle behaviour of high-strength concrete using keratin and glass fibres
Abdelsamie, Khaled,Agwa, Ibrahim Saad,Tayeh, Bassam A.,Hafez, Radwa Defalla Abdel Techno-Press 2021 Advances in concrete construction Vol.12 No.6
Keratin fibres are waste products of the poultry industry. Natural materials made from chicken feather fibres (CFFs) are used in concrete-reinforced composites in this study. Brittleness is a major problem of high-strength concrete (HSC) that leads to sudden failure at the ultimate capacity of concrete. Hence, this work aims to investigate effects of using CFFs on improving the brittle behaviour of HSC. Two scenarios are performed to analyse the effectiveness of using CFFs. HSC containing different ratios of CFF (0% as the control, 0.5%, 1%, 1.5%, 2%, and 3%) by volume are tested in the first scenario. Glass fibres (GF) are used to replace CFFs in the other scenario. Tests of fresh, hardened and morphological properties for concrete are performed. Results showed the enhanced brittle behaviour of HSC when using both types of fibres. The preferable ratio of both types of fibres is 1% by volume. Flexural and splitting tensile strengths increased by about 44.9 % and 42.65 % for mixes containing 0.1% GF, respectively. While they were increased by about 21.6 % and 21.16 % for mixes containing 0.1% CFF, respectively.
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A Chemotherapy-Diffusion Model for the Cancer Treatment and Initial Dose Control
Abdel-Gawad, Hamdy Ibrahim,Saad, Khaled Mmohamed Department of Mathematics 2008 Kyungpook mathematical journal Vol.48 No.3
A one site chemotherapy agent-diffusion model is proposed which accounts for diffusion of chemotherapy agent, normal and cancer cells. It is shown that, by controlling the initial conditions, consequently an initial dose of the chemotherapy agent, the system is guaranteed to evolute towards a target equilibrium state. Or, growth of the normal cells occurs against decay of the cancer cells. Effects of diffusion of chemotherapy-agent and cells are investigated through numerical computations of the concentrations in square and triangular cancer sites.
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Darwish Badran,Ayman El-Baz El-Agroudy,Amira Adly Kassab,Khaled Saad El-Bayoumi,Zienab Helmy Eldken,Noha Ramadan Mohammed Elswaidy 대한해부학회 2024 Anatomy & Cell Biology Vol.57 No.1
The world has witnessed tremendous advancements in nano-base applications. Zinc oxide nanoparticles (ZON) are widely used in food industry and medicine. Although their application is of important value, they may cause toxicity to body tissues. Peripheral blood mononuclear cells (PBMCs) proved its efficacy in tissue regeneration especially when it is preconditioned by activated platelet supernatant (APS). The aim of this study is to evaluate the effect of ZON on the gastric mucosa and the therapeutic role of the PBMCs preconditioned by APS in rats. Ten rats were donors and fifty rats were recipients. The recipients were divided into; control group, ZON group (10 mg/kg/day orally for five days) and preconditioned PBMCs group (1×107 once intravenously 24 hours after ZON). Gastric specimens were processed for histological, immunohistochemical, biochemical and quantitative real-time polymerase chain reaction studies. ZON group showed marked structural changes in the gastric mucosa. There was desquamation or deep ulceration of the epithelium. Cytoplasmic vacuoles and pyknotic nuclei were in glandular cells. Reduced proliferating cell nuclear antigen and increased tumor necrosis factor-α were in epithelial cells. There were significant elevation in malondialdahyde and reduction in glutathione, superoxide dismutase, and catalase. Enhancement in mRNA expression of nuclear factor kappa-B and cyclooxygenase-2 was detected. The preconditioned PBMCs group showed significant improvement of all parameters. So, ZON had cytotoxic effects on the gastric mucosa and the preconditioned PBMCs had a therapeutic effect on gastric mucosal damage after ZON.
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Al-Darwish, Abdulaziz Ahmed,Al-Naim, Abdullah Fouad,Al-Mulhim, Khalid Saleh,Al-Otaibi, Nasser Khaled,Morsi, Mohammed Saad,Aleem, Ansari Mukhtar Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.6
Background: Cervical cancer is the second most common cancer among females and also the most preventable. In the literature there is abundant evidence that awareness regarding cervical cancer and its prevention is low in the developing countries. Medical students are the future health professionals and can play an important role in increasing awareness among the general population. To assess the knowledge regarding symptoms, risk factors and prevention of cervical carcinoma among medical students in th Kingdom of Saudi Arabia, the present study was planned. Materials and Methods: This cross-sectional study was conducted using a self-administered questionnaire with students at the College of Medicine, King Faisal University, Al-Ahsa, KSA, from December 2012 to May 2013. Results: The responses of 188 students (males 111, females 77) in their second, third, fourth, and fifth years were recorded and used in the data analysis. The majority of the students were not aware of the early warning signs, symptoms and risk factors. On average, only 43.7% males and 56% of females were aware about the early signs and symptoms whereas 51.4% males and 57.8% females had knowledge about the risk factors of cervical cancers. Some 55% males and 46.8% females were unable to select the correct answer regarding human papilloma virus (HPV) infection as the cause of cervical cancer. Majority of the students (67%) were not aware about the availability of vaccine against HPV. Conclusions: Lack of knowledge regarding early signs and symptoms, risk factors and prevention of cervical cancer was observed in the present study.
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