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- 저자 : Kenny K. Kim (검색결과 2 건)
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Gonadal Tumors Developed from Consecutively Transplanted Spleens Bearing Gonad Implants
홍인철,이선,우창현,Kenny K. Kim,Jason Kim,Gregory Emmanuel,Slawomir Niewiadomski,Paul Wolf,Ruben F. Gittes 연세대학교의과대학 2004 Yonsei medical journal Vol.45 No.6
This study was conducted by consecutively transplanting spleens, which had gonads implanted previously. A total of 84 cases for infantile testicles and 106 cases for ovarian follicles were performed. In the case of ovarian implants, the results were determined by the total number of follicle implants. A modified spleen transplantation technique called double implantation of ovarian follicles was applied to increase the amount of the implants. In this technique, an extra spleen is implanted into the potential donor so that the ovarian follicles can be implanted to two different spleens, doubling the amount of implants. Through consecutive spleen transplantation, we observed the results beyond a typical rat's life span. In many of these cases, we found more aggressive forms of malignant tumor, seminoma and dysgerminoma. We present the results and discuss possible pathogenic mechanisms of tumor formation.
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Isabel Kerrebijn,Sarah Atwi,Mai Elfarnawany,Andrew M. Eib,Joseph K. Eibl,Jenna L. Taylor,Kim Chul-Ho,Johnson Bruce D.,Jon-Émile S. Kenny 대한중환자의학회 2024 Acute and Critical Care Vol.39 No.1
Background: Using peripheral arteries to infer central hemodynamics is common among hemodynamic monitors. Doppler ultrasound of the common carotid artery has been used in this manner with conflicting results. The aim of this study was to investigate the relationship between changing common carotid artery Doppler measures and stroke volume (SV). We hypothesized that correlation between SV and carotid Doppler would improve with larger numbers of consecutively-averaged cardiac cycles. Methods: Twenty-seven healthy volunteers were recruited and studied in a physiology laboratory. Carotid artery Doppler pulse was measured with a wearable, wireless ultrasound during central hypovolemia and resuscitation induced by a stepped lower body negative pressure protocol. The change in maximum velocity time integral (VTI) and corrected flow time of the carotid artery (ccFT) were compared with changing SV using repeated measures correlation. Results: In total, 73,431 cardiac cycles were compared across 27 subjects. There was a strong linear correlation between changing SV and carotid Doppler measures during simulated hemorrhage (repeated-measures linear correlation [Rrm]=0.91 for VTI; 0.88 for ccFT). This relationship improved with larger numbers of consecutively-averaged cardiac cycles. For ccFT, beyond four consecutively-averaged cardiac cycles the correlation coefficient remained strong (i.e., Rrm of at least 0.80). For VTI, the correlation coefficient with SV was strong for any number of averaged cardiac cycles. For both ccFT and VTI, Rrm remained stable around 25 consecutively-averaged cardiac cycles. Conclusions: Using a wearable carotid Doppler ultrasound 73,431 cardiac cycles were compared to SV during central volume loss and resuscitation induced.
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