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RISS 인기검색어
- 검색키워드
- 저자 : Johnson Bruce D. (검색결과 2 건)
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( Joshua Donkor ),( Alex R. Carlson ),( Briana L. Ziegler ),( Jessica I. Johnston ),( Jinkyung Cho ),( Bruce D. Johnson ),( Chul-ho Kim ) 대한스포츠의학회 2023 대한스포츠의학회지 Vol.41 No.2
Purpose: The study was to investigate exercise capacity (peak oxygen uptake [peak VO<sub>2</sub>]) and pulmonary capacitance (GX<sub>cap</sub>), which is an estimate of pulmonary vascular capacitance, in patients with nonalcoholic steatohepatitis (NASH). Methods: This study utilized a database of patients with NASH (n=26 [17 male and 9 female], aged 58.9±4.3 years) and healthy individuals (n=23 [12 male and 11 female, aged 58.6±7.9 years) who underwent a maximal exercise test on a recumbent cycle ergometer (Corival; Lode) in our laboratory. During cardiopulmonary exercise tests, breathing patterns and respiratory gas exchange including breathing efficiency (VE/VCO<sub>2</sub>) and end-tidal CO<sub>2</sub> (PETCO<sub>2</sub>) were measured. In addition, peak VO<sub>2</sub> was obtained via averaging the last 30 seconds at peak level and GX<sub>cap</sub> was obtained by calculation as follows: GX<sub>cap</sub>=oxygen pulse (O<sub>2</sub> pulse)×PETCO<sub>2</sub>. Results: The NASH group demonstrated reduced peak VO<sub>2</sub> relative to the healthy group (17.5±8.4 mL/kg/min vs. 34±10.2 mL/kg/min, respectively; p< 0.05). In addition, there was a higher VE/VCO<sub>2</sub> relationship in the NASH group relative to the healthy group (34.9±5.5 vs. 32.2±4.0, respectively; p< 0.05) and lower PETCO<sub>2</sub> in the NASH group compared to the healthy group (32.8±4.0 mm Hg vs. 35.3±3.8 mm Hg, respectively; p< 0.05). Furthermore, the NASH group showed lower GX<sub>cap</sub> than the healthy group (456±150 vs. 551±202, respectively; p< 0.05). Conclusion: Patients with NASH had reduced exercise capacity and pulmonary vascular capacitance relative to age-matched healthy adults and this may contribute to pulmonary pathophysiology in NASH.
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Isabel Kerrebijn,Sarah Atwi,Mai Elfarnawany,Andrew M. Eib,Joseph K. Eibl,Jenna L. Taylor,Kim Chul-Ho,Johnson Bruce D.,Jon-Émile S. Kenny 대한중환자의학회 2024 Acute and Critical Care Vol.39 No.1
Background: Using peripheral arteries to infer central hemodynamics is common among hemodynamic monitors. Doppler ultrasound of the common carotid artery has been used in this manner with conflicting results. The aim of this study was to investigate the relationship between changing common carotid artery Doppler measures and stroke volume (SV). We hypothesized that correlation between SV and carotid Doppler would improve with larger numbers of consecutively-averaged cardiac cycles. Methods: Twenty-seven healthy volunteers were recruited and studied in a physiology laboratory. Carotid artery Doppler pulse was measured with a wearable, wireless ultrasound during central hypovolemia and resuscitation induced by a stepped lower body negative pressure protocol. The change in maximum velocity time integral (VTI) and corrected flow time of the carotid artery (ccFT) were compared with changing SV using repeated measures correlation. Results: In total, 73,431 cardiac cycles were compared across 27 subjects. There was a strong linear correlation between changing SV and carotid Doppler measures during simulated hemorrhage (repeated-measures linear correlation [Rrm]=0.91 for VTI; 0.88 for ccFT). This relationship improved with larger numbers of consecutively-averaged cardiac cycles. For ccFT, beyond four consecutively-averaged cardiac cycles the correlation coefficient remained strong (i.e., Rrm of at least 0.80). For VTI, the correlation coefficient with SV was strong for any number of averaged cardiac cycles. For both ccFT and VTI, Rrm remained stable around 25 consecutively-averaged cardiac cycles. Conclusions: Using a wearable carotid Doppler ultrasound 73,431 cardiac cycles were compared to SV during central volume loss and resuscitation induced.
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