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RISS 인기검색어
- 검색키워드
- 저자 : Keita Hirai (검색결과 2 건)
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Contribution of ipRGC to the Fluorescent Feeling
Yuki Tanaka,Keita Hirai,Midori Tanaka,Takahiko Horiuchi,Katsunori Okajima 한국색채학회 2017 AIC 2017 Jeju Vol.2017 No.10
Fluorescence is generated when a substance absorbs light energy at a short wavelength and then emits light energy at a longer wavelength. This unique characteristic evokes a “fluorescent feeling,” which is different from the perception that is detected when objects reflect light. In our previous study, when an image that was colorimetrically equivalent to a real fluorescent object was reproduced on a monitor, the fluorescent feeling evoked by the reproduced image was reduced. This suggested that the differences in spectral distribution between a reproduced image and a real fluorescent object can affect the fluorescent feeling. In recent years, the role of intrinsically photosensitive retinal ganglion cells (ipRGCs) in the detection of brightness has been reported. In this study, we investigate the contribution of ipRGCs to the fluorescent feeling. In our experiment, ipRGC stimulation was tested and compared to the light flux stimulus. We investigated both central vision and peripheral vision. We found that as ipRCG excitation increased, the participants perceived a larger fluorescent feeling. In addition, a large fluorescent feeling was perceived in the peripheral vision, where ipRGCs play a prominent role in image detection. These results indicate that ipRGCs are important for the development of the fluorescent feeling.
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Mucus Plugs and Small Airway Dysfunction in Asthma, COPD, and Asthma-COPD Overlap
Tamura Kanami,Shirai Toshihiro,Hirai Keita,Nakayasu Hiromasa,Takahashi Shingo,Kishimoto Yutaro,Akamatsu Taisuke,Asada Kazuhiro,Kato Satoshi 대한천식알레르기학회 2022 Allergy, Asthma & Immunology Research Vol.14 No.2
Purpose: There are reports concerning mucus plugs detected on high-resolution computed tomography images and airflow obstruction in asthma and chronic obstructive pulmonary disease (COPD). However, little is known about the associations between mucus plugs and small airway dysfunction (SAD). We evaluated the relationship between mucus plugs and pulmonary function in patients with asthma, COPD, and asthma-COPD overlap (ACO), and investigated the relevance to SAD and type 2 inflammation in a retrospective study. Methods: Subjects included 49 asthmatic, 40 ACO, and 41 COPD patients. ACO was diagnosed based on the Japanese Respiratory Society ACO guidelines. Clinical and laboratory parameters, including blood eosinophil count, serum total IgE levels, fractional exhaled nitric oxide (FeNO), spirometry, and forced oscillation technique (FOT), were compared between patients with and without mucus plugs. Results: Mucus plugs were found in 29 (59%) asthmatic, 25 (65%) ACO, 17 (41%) COPD patients. Patients with mucus plugs had reduced spirometry and larger FOT parameters, especially in COPD patients. Mucus scores correlated positively with IgE in ACO and FeNO in asthmatic patients, but not in COPD patients. Multivariate logistic regression analysis revealed that SAD parameters, including forced vital capacity and resonant frequency, a respiratory reactance parameter, were significantly associated with the presence of mucus plugs in the whole studied population. Conclusions: SAD, rather than large airway dysfunction, was associated with mucus plugs in asthma, ACO, and COPD patients.
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