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RISS 인기검색어
- 검색키워드
- 저자 : Kathy Yuan (검색결과 3 건)
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Kim, Kyung-Ah,Yoo, Hye Hyun,Gu, Wan,Yu, Dae-Hyung,Jin, Ming Ji,Choi, Hae-Lim,Yuan, Kathy,Guerin-Deremaux, Laetitia,Kim, Dong-Hyun The Korean Society of Ginseng 2015 Journal of Ginseng Research Vol.39 No.2
Background: Gut microflora play a crucial role in the biotransformation of ginsenosides to compound K (CK), which may affect the pharmacological effects of ginseng. Prebiotics, such as NUTRIOSE, could enhance the formation and consequent absorption of CK through the modulation of gut microbial metabolic activities. In this study, the effect of a prebiotic fiber (NUTRIOSE) on the pharmacokinetics of ginsenoside CK, a bioactive metabolite of ginsenosides, and its mechanism of action were investigated. Methods: Male Sprague-Dawley rats were given control or NUTRIOSE-containing diets (control diet + NUTRIOSE) for 2 wk, and ginseng extract or vehicle was then orally administered. Blood samples were collected to investigate the pharmacokinetics of CK using liquid chromatography-tandem mass spectrometry. Fecal activities that metabolize ginsenoside Rb1 to CK were assayed with fecal specimens or bacteria cultures. Results: When ginseng extract was orally administered to rats fed with 2.5%, 5%, or 10% NUTRIOSE containing diets, the maximum plasma concentration ($C_{max}$) and area under the plasma concentration-time curve values of CK significantly increased in a NUTRIOSE content-dependent manner. NUTRIOSE intake increased glycosidase activity and CK formation in rat intestinal contents. The CK-forming activities of intestinal microbiota cultured in vitro were significantly induced by NUTRIOSE. Conclusion: These results show that prebiotic diets, such as NUTRIOSE, may promote the metabolic conversion of ginsenosides to CK and the subsequent absorption of CK in the gastrointestinal tract and may potentiate the pharmacological effects of ginseng.
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김경아,유혜현,Wan Gu,Dae-Hyung Yu,Ming Ji Jin,Hae-Lim Choi,Kathy Yuan,Laetitia Guerin-Deremaux,김동현 고려인삼학회 2015 Journal of Ginseng Research Vol.39 No.2
Background: Gut microflora play a crucial role in the biotransformation of ginsenosides to compound K(CK), which may affect the pharmacological effects of ginseng. Prebiotics, such as NUTRIOSE, couldenhance the formation and consequent absorption of CK through the modulation of gut microbialmetabolic activities. In this study, the effect of a prebiotic fiber (NUTRIOSE) on the pharmacokinetics ofginsenoside CK, a bioactive metabolite of ginsenosides, and its mechanism of action were investigated. Methods: Male SpragueeDawley rats were given control or NUTRIOSE-containing diets (controldiet þ NUTRIOSE) for 2 wk, and ginseng extract or vehicle was then orally administered. Blood sampleswere collected to investigate the pharmacokinetics of CK using liquid chromatographyetandem massspectrometry. Fecal activities that metabolize ginsenoside Rb1 to CK were assayed with fecal specimensor bacteria cultures. Results: When ginseng extract was orally administered to rats fed with 2.5%, 5%, or 10% NUTRIOSEcontaining diets, the maximum plasma concentration (Cmax) and area under the plasma concentrationetime curve values of CK significantly increased in a NUTRIOSE content-dependent manner. NUTRIOSEintake increased glycosidase activity and CK formation in rat intestinal contents. The CK-forming activitiesof intestinal microbiota cultured in vitro were significantly induced by NUTRIOSE. Conclusion: These results show that prebiotic diets, such as NUTRIOSE, may promote the metabolicconversion of ginsenosides to CK and the subsequent absorption of CK in the gastrointestinal tract andmay potentiate the pharmacological effects of ginseng.
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김경아,유혜현,Wan Gu,Dae-Hyung Yu,Ming Ji Jin,Hae-Lim Choi,Kathy Yuan,Laetitia Guerin-Deremaux,김동현 고려인삼학회 2014 Journal of Ginseng Research Vol.38 No.3
Background: There is limited understanding of the effect of dietary components on the absorption ofginsenosides and their metabolites into the blood. Methods: This study investigated the pharmacokinetics of the ginseng extract and its main constituentginsenoside Rb1 in rats with or without pretreatment with a prebiotic fiber, NUTRIOSE, by liquidchromatography tandem mass spectrometry. When ginsenoside Rb1 was incubated with rat feces, itsmain metabolite was ginsenoside Rd. Results: When the intestinal microbiota of rat feces were cultured in vitro, their ginsenoside Rd-formingactivities were significantly induced by NUTRIOSE. When ginsenoside Rb1 was orally administered torats, the maximum plasma concentration (Cmax) and area under the plasma drug concentrationetimecurve (AUC) for the main metabolite, ginsenoside Rd, were 72.4 31.6 ng/mL and 663.9 285.3 mg$h/mL, respectively. When the ginseng extract (2,000 mg/kg) was orally administered, Cmax and AUC forginsenoside Rd were 906.5 330.2 ng/mL and 11,377.3 4,470.2 mg$h/mL, respectively. When ginsengextract was orally administered to rats fed NUTRIOSE containing diets (2.5%, 5%, or 10%), Cmax and AUCwere increased in the NUTRIOSE receiving groups in a dose-dependent manner. Conclusion: These findings reveal that intestinal microflora promote metabolic conversion of ginsenosideRb1 and ginseng extract to ginsenoside Rd and promote its absorption into the blood in rats. Its conversionmay be induced by prebiotic diets such as NUTRIOSE.
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