http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Lee, D.,Bae, S.,Ke, Q.,Lee, J.,Song, B.,Karumanchi, S.A.,Khang, G.,Choi, H.S.,Kang, P.M. Elsevier Science Publishers 2013 Journal of controlled release Vol.172 No.3
The main culprit in the pathogenesis of ischemia/reperfusion (I/R) injury is the generation of high level of hydrogen peroxide (H<SUB>2</SUB>O<SUB>2</SUB>). In this study, we report a novel diagnostic and therapeutic strategy for I/R injury based on H<SUB>2</SUB>O<SUB>2</SUB>-activatable copolyoxalate nanoparticles using a murine model of hind limb I/R injury. The nanoparticles are composed of hydroxybenzyl alcohol (HBA)-incorporating copolyoxalate (HPOX) that, in the presence of H<SUB>2</SUB>O<SUB>2</SUB>, degrades completely into three known and safe compounds, cyclohexanedimethanol, HBA and CO<SUB>2</SUB>. HPOX effectively scavenges H<SUB>2</SUB>O<SUB>2</SUB> in a dose-dependent manner and hydrolyzes to release HBA which exerts intrinsic antioxidant and anti-inflammatory activities both in vitro and in vivo models of hind limb I/R. HPOX nanoparticles loaded with fluorophore effectively and robustly image H<SUB>2</SUB>O<SUB>2</SUB> generated in hind limb I/R injury, demonstrating their potential for bioimaging of H<SUB>2</SUB>O<SUB>2</SUB>-associated diseases. Furthermore, HPOX nanoparticles loaded with anti-apoptotic drug effectively release the drug payload after I/R injury, exhibiting their effectiveness for a targeted drug delivery system for I/R injury. We anticipate that multifunctional HPOX nanoparticles have great potential as H<SUB>2</SUB>O<SUB>2</SUB> imaging agents, therapeutics and drug delivery systems for H<SUB>2</SUB>O<SUB>2</SUB>-associated diseases.