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Zeynep Nur Karadogan,Yasar Tanir,Ali Karayagmurlu,Canan Kucukgergin,Murat Coskun 대한정신약물학회 2023 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.21 No.4
Objective: Despite being highly genetic, the etiology of autism spectrum disorder (ASD), has not yet been clarified. Recent research has focused on the role of neuroinflammation and immune system dysfunction in the pathophysiology of neurodevelopmental disorders including ASD. Galectin-1 and galactin-3 are considered among the biomarkers of neuroinflammation and there has been recent reports on the potential role of galectins in the etiology of neurodevelopmental disorders. However, there has been no study examining the relationship between ASD and galectin levels. Methods: Current study aimed to investigate galectin-1 and galectin-3 serum levels in young subjects with ASD comparing with their unaffected siblings and healthy controls. Results: We found significantly higher levels of galectin-1 in case group compared to both unaffected siblings and healthy controls, and higher levels of galectin-3 in case group compared to healthy controls. However, there was no significant association between galectin-1 and galectin-3 levels with the severity of ASD. Conclusion: Findings of our study may support neuroinflammation hypothesis in the etiology of ASD and the potential role of galectin-1 and galectin-3 as biomarkers.
Local thin jacketing for the retrofitting of reinforced concrete columns
Yuce, Serkan Z.,Yuksel, Ercan,Bingol, Yilmaz,Taskin, Kivanc,Karadogan, H. Faruk Techno-Press 2007 Structural Engineering and Mechanics, An Int'l Jou Vol.27 No.5
Two series of tests were conducted to investigate the behavior of local thin jacketing for the retrofitting of reinforced concrete (RC) columns. In the first series, four full-scale RC columns with a height of 400 cm and a 30 cm square cross-section were tested under constant axial load and reversed cyclic lateral displacements. The heavily damaged columns were retrofitted with local thin jacketing. Self-compacting concrete (SCC) was used in the production of 7.5 cm thick, four-sided jacketing. The height of the jacketing was 100 cm for one specimen and 200 cm for all others. In the second series, the retrofitted columns were retested with the same axial load and displacement history. The effectiveness of local thin jacketing in the retrofitting of RC columns was examined with respect to lateral strength, stiffness, inelastic load-deformation behavior and energy dissipation.
Uni-axial behavior of energy dissipative steel cushions
Hasan ozkaynak,Arastoo Khajehdehi,Ahmet Gullu,Faraz Azizisales,Ercan Yuksel,Faruk Karadogan 국제구조공학회 2018 Steel and Composite Structures, An International J Vol.27 No.6
Seismic excitations may impart a significant amount of energy into structures. Modern structural design attitudes tend to absorb some part of this energy through special dissipaters instead of heavy plastic deformations on the structural members. Different types of dissipater have been generated and utilized in various types of structures in last few decades. The expected earthquake damage is mainly concentrated on these devices and they may be replaced after earthquakes. In this study, a low-cost device called <i>energy dissipative steel cushion</i> (EDSC) made of flat mild steel was developed and tested in the Structural and Earthquake Engineering Laboratory (STEELab) of Istanbul Technical University (ITU). The monotonic and cyclic tests of EDSC were performed in transversal and longitudinal directions discretely. Very large deformation capability and stable hysteretic behavior are some response properties observed from the tests. Load vs. displacement relations, hysteretic energy dissipation properties as well as the closed form equations to predict the behavior parameters are presented in this paper.
Numerical Modelling of Energy Dissipative Steel Cushions
Ahmet Gullu,Eleni Smyrou,Arastoo Khajehdehi,Hasan ozkaynak,I. Engin Bal,Ercan Yuksel,Faruk Karadogan 한국강구조학회 2019 International Journal of Steel Structures Vol.19 No.4
Energy dissipative steel cushions (EDSCs) are simple units that can be used to join structural members. They can absorb a substantial amount of seismic energy due to their geometric shapes and the ductile behavior of mild steel. Large deformation capability and stable hysteretic behavior were obtained in monotonic and cyclic tests of EDSCs in the framework of the SAFECLADDING project. Discrete numerical modeling strategies were applied to reproduce the experimental results. The fi rst and second models comprise two-dimensional shell elements and one-dimensional fl exural frame elements, respectively. The uncertain points in the preparation of the models included the mesh density, representation of the material properties, and interaction between contacting surfaces. A zero-length nonlinear link element was used in the third attempt in the numerical modeling. Parameters are recommended for the Ramberg–Osgood and bilinear models. The obtained results indicate that all of the numerical models can reproduce the response, and the stiff ness, strength, and unloading and reloading curves were fi tted accurately.