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전두수(Doo Soo Jeon),정해억(Hae Uk Chung),승기배(Ki Bae Seung),강동헌(Dong Hun Kang),김상우(Sang Wo Kim),김용주(Young Ju Kim),채장성(Jang Sung Chae),김재형(Jae Hyung Kim),홍순조(Soon Jo Hong),최규보(Kyu Bo Choi) 대한내과학회 1996 대한내과학회지 Vol.50 No.6
N/A Objectives: Cardiogenic shock resulting from acute myocardial infarction is a serious complication with high mortality. The early identification of patients at high risk of developing post-infarction cardiogenic shock might allow early intervention in an attempt to prevent cardiogenic shock and to reduce the mortality due to cardiogenic shock. The aim of the present study was to examine the risk factors of inhospital development of cardiogenic shock among patients with acute myocardial infarction. Methods: We studied 152patients with acute myocardial infarction who were admitted to Kang-Nam St. Mary's hospital within 24hours after the onset of chest pain and did not have cardiogenic shack on admission between March 1991 and May 1994. Clinical data of these patients were analyzed. Results: Of 152patients, 17(11.1%) developed cardiogenic shock during their hospital stay. Cardiogenic shock developed in 53% of cases more than 24hours after admission. 82.4% of patients with cardiogenic shock died whereas a 6.7% in-hospital mortality was found among patients without cardiogenic shock. Multivariate regression analysis that controlled for variables affecting incidence of postinfarction cardiogenic shock showed that independent risk factors for in-hospital cardiogenic shock were history of myocardial infarction (adjusted relative odds[RO]=5.294, 95% confidence interval[CI]=2.149 to 13.041); heart failure on admission (RO=3.344, 95% CI=1.738 to 6.432); hyperglycemia (>180mg/dl) in non-diabetic patients (RO=3.270, 95% CI=1,590 to 6.727); age over 70 year old (RO=2.912, 95% CI= 1.816 to 4.668); ST deviation over 4mm (RO=2.417, 95% CI=1.225 to 4.767); peak LDH level greater than 1600U/ml (RO=1.154, 95% CI=1.080 to 1.233). Patients with one independent risk factor had an estimated probability of 10.5% for developing inhospital cardiogenic shock; patients with two independent risk factors, 48.5%, patients with three risk factors, 65.0% patients with four risk factors, 65.7% patients with five risk factors, 67.2%. Conclusion: Of post-infarction cardiogenic shock during admission, 53% developed more than 24hours after admission. The more independent risk factors on admission for inhospital cardiogenic shock patients with acute myocardial infarction had, the more likely in-hospital cardiogenic shock developed.
Kang, Young Sun,Park, Yun Gyu,Kim, Bo Kyung,Han, Sang Youb,Jee, Yi Hwa,Han, Kum Hyun,Lee, Mi Hwa,Song, Hye Kyoung,Cha, Dae Ryong,Kang, Shin Wook,Han, Dae Suk Journal of Endocrinology (Ltd. by Guarantee) 2006 Journal of molecular endocrinology Vol.36 No.2
<P>Angiotensin II (Ang-II) and vascular endothelial growth factor (VEGF) have an important role in the pathogenesis of diabetic nephropathy, but the signaling cascade of VEGF regulation in response to Ang-II in podocytes is largely unknown. In these experiments, we looked at the effect of Ang-II on the production of VEGF, and investigated whether VEGF production depends on the p38 mitogen activated protein kinase (MAPK) pathway in cultured mouse podocytes. Incubation of podocytes with Ang-II induced a rapid increase in VEGF mRNA expression and protein synthesis as well as its transcriptional activity in an Ang-II dose-dependent manner. To further define the role of angiotensin type 1 (AT1) and type 2 (AT2) receptors involved in Ang-II-mediated VEGF synthesis, the effects of selective AT1 and AT2 receptor antagonists were evaluated. Prior treatment with losartan significantly inhibited VEGF mRNA and protein synthesis induced by Ang-II, which suggests that the AT1 receptor is involved in Ang-II-mediated VEGF synthesis. Furthermore, stimulation of the cells with Ang-II increased both phosphorylation of p38 MAPK and MAP kinase kinase 3/6 (MKK3/6). Additionally, Ang-II enhanced the DNA binding activity to cAMP response element binding protein (CREB) and phosphorylation of CREB. In addition, to investigate the role of p38 MAPK in Ang-II-induced VEGF synthesis, podocytes were pretreated with or without the p38 MAPK inhibitor, SB203580 for 24 h to observe whether Ang-II-mediated VEGF synthesis was inhibited by blocking p38 MAPK. The addition of SB203580 led to a marked inhibition of the increased VEGF mRNA and protein production induced by Ang-II in a dose-dependent manner. Taken together, these results suggest that Ang-II stimulates the synthesis of VEGF in podocytes and the production of VEGF induced by Ang-II is mediated, in part, through the activation of the p38 MAPK pathway.</P>
Seroprevalence of tuberculosis in domesticated elk (<i>Cervus canadensis</i>) in Korea
Kang, Shin-Seok,Byeon, Hyeon-Seop,Ku, Bok Kyung,Kim, Sang Woo,Kim, Jiro,Woo, Jeongim,Ahn, Byeongwoo,Kim, Soojin,Monoldorova, Sezim,Park, Chan-Ho,Cho, Sang-Nae,Jeon, Bo-Young Elsevier 2016 Research in veterinary science Vol.107 No.-
<P><B>Abstract</B></P> <P>Tuberculosis is a contagious disease in animals, primarily cattle, although it also affects wild animals and humans. There are few data on the state of tuberculosis in domesticated elk (<I>Cervus canadensis</I>) in Korea. In order to investigate tuberculosis in elk, the effectiveness of an enzyme linked immunosorbent assay (ELISA) using MPB70 and MPB83 antigens was compared with the tuberculin skin test (TST), and seroprevalence was measured with this assay using serum samples collected from domesticated elk herds in Korea. The respective sensitivities of the MPB70 and MPB83 ELISAs were 51.9% (95% CI 42.0–61.6) and 49.1% (95% CI 39.3–58.9), and their specificities were 100.0% (95% CI 92.6–100.0) and 97.9% (95% CI 88.9–100.0), respectively, in comparison with the TST. The herd prevalence ranged from 50 to 80% and the mean herd seropositive rate was 67.7% (21 of 31). Of 819 serum samples, 163 (19.9%) were seropositive, and the within-region prevalence ranged from 18.5–58.0%. In conclusion, the ELISA using the MPB70 and MPB83 antigens showed moderate sensitivity and high specificity compared to TST in elk, and tuberculosis was assumed to be fairly prevalent in domesticated elk in Korea.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Establishment of ELISA using the MPB70 and MPB83 antigens for tuberculosis of elk </LI> <LI> Performance of these ELISAs (sensitivity and specificity) compared with TST </LI> <LI> Estimation of seroprevalence of tuberculosis in elk in Korea using these ELISAs </LI> <LI> First report on prevalence data of tuberculosis in domesticated elk in Korea </LI> <LI> A basic epidemiological data of tuberculosis in elk in an Asian region </LI> </UL> </P>
Kang Ryong Choi,Seung Je Moon,Taejoon Kouh,In Bo Shim,Sam Jin Kim,Chul Sung Kim IEEE 2009 IEEE transactions on magnetics Vol.45 No.6
<P>CoCr<SUB>2</SUB>O<SUB>4</SUB>(CCO) materials show multiferroic effect that ferroelectricity and ferromagnetism co-exist. CCO film was deposited on Pt/Ti/Si/SiO<SUB>2</SUB> substrates by pulsed laser deposition (PLD). The CCO film were prepared using KrF(248 nm) excimer lasers and with a pressure of 100 mTorr, substrate temperatures of 700<SUP>deg</SUP>C . The crystal structure was found to be oriented {111} planes by means of X-ray diffraction (XRD) with Cu radiation. The morphology of film has showed triangle shapes. The ferrimagnetic transition was observed at around 95 K, which was determined as Neel temperature and spiral magnetic transition temperature (<I>T</I> <SUB>S</SUB>) was 21.5 K, while the <I>T</I> <SUB>S</SUB> of bulk CCO was 28.0 K. We note that decreasing of <I>T</I> <SUB>S</SUB> in CCO films is closely related to the preferred orientation of {111} direction.</P>
Diniconazole 처리가 일일초와 샐비어의 생장 및 개화에 미치는 영향
Sung-Hwan Choi(최성환),Jum-Soon Kang(강점순),Young-Whan Choi(최영환),Yong-Jae Lee(이용재),Young-Hoon Park(박영훈),Mi-Ra Kim(김미라),Beung-Gu Son(손병구),Hyeun-Kyeung Kim(김현경),Hong-Yul Kim(김홍열),Wook Oh(오욱),Hak-Bo Sim(심학보) 한국생명과학회 2011 생명과학회지 Vol.21 No.7
따라서 본 실험에서는 생장 억제에 효과 있는 기존의 생장억제제인 스미세븐은 고가의 생장억제제이므로 이을 대신할 수 있으며 지금까지는 주로 살균제로 사용되고 있는 빈나리의 농도별 처리가 일일초과 샐비어의 생장 및 개화에 미치는 영향에 대해서 조사하였다. 일일초와 샐비어 모두 빈나리처리에 의해서 생장이 억제되었다. 두 식물체 모두 빈나리 100 ㎎/ℓ 처리가 스미세븐 5 ㎎/ℓ보다 높은 생장억제효과를 나타내었다. 빈나리 처리에 의해서 두 식물체 모두 엽장은 감소하였으나 엽폭은 큰 변화가 없었다. 그 결과 엽형이 둥굴어지는 현상이 나타났다. 개화소요일수는 일일초과 샐비어 모두 대조구에 비해 빈나리 처리시 증가하였다. 일일초의 꽃수는 빈나리 400 ㎎/ℓ 처리를 제외하고 대조구와 큰 차이가 없었다. 샐비어의 경우 빈나리 100, 200 ㎎/ℓ 처리에 의해서 소화수가 증가하였다. This study was conducted to investigate the effects of uniconazole (Sumiseven), an existing expensive growth retardant, and diniconazole (Binnari), used as a cheap germicide, on the growth and flowering of Vinca major and Salvia splendis for the possibility of substitution for expensive growth retardants. The growths of V. major and S. splendis were retarded by Binnari treatment. The effect of Binnari 100 ㎎/ℓ treatment was higher than that of Sumiseven 5 ㎎/ℓ treatment in both plants. The length of leaves was remarkably retarded by Binnari treatment, however, the width of leaves was only slightly retarded, giving the leaf a round shape. The number of days to flowering was increased by Binnari treatment in both in V. major and S. splendis. The number of days to flowering in V. major showed no significant difference compared to the control except by treatemtn with Binnari 400 ㎎/ℓ. The number of florets of S. splendis increased with treatment with Binnari 100 and 200 ㎎/ℓ.