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P124 : The efficacy and safety of cryo fat reduction in the treatment of pseudogynecomastia
( Jung Tae Park ),( Bori Kim ),( Sang Young Byun ),( Soon Hyo Kwon ),( Jung Won Shin ),( Kyoung Chan Park ),( Jung Im Na ),( Chang Hun Huh ) 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.2
Background: Options for the treatment of pseudogynecomastia, a condition of enlarged male breast primarily due to the accumulation of adipose tissue, have been limited, including weight reduction and surgical liposuction. Cryo fat reduction provides noninvasive, selective, localized subcutaneous adipocyte destruction without epidermal or dermal injury by inducing adipocyte apoptosis. Objectives: This study was designed to evaluate the efficacy of cryo fat reduction in the treatment of pseudogynecomastia. Methods: In this prospective, 28-week trial, 12 male patients with psudogynecomastia were treated with cryo fat reduction twice bimonthly. Efficacy was determined by breast circumference measurement, ultrasonographic measurement of subcutaneous layer thickness, physician’s global photographic assessment, and patient’s satisfaction at baseline at week 4, week 8, week 16 and week 28. Safety was evaluated by questionnaire at each visit. Results: For the 11 subjects completing the trial, breast circumference and thickness of fat layer determined by ultasonography significantly improved at week 8, andgradually reduced until week 28. Physician’s photographic assessment and patient’s satisfaction showed significant improvement at each visit. No adverse event was observed except transient pain immediately after the treatment and bruise at the treated site. Conclusion: Cryo fat reduction is a safe and effective therapeutic option of the treatment of pseudogynecomastia.
HUH, Sun Young,SHIN, Jung-Won,NA, Jung-Im,HUH, Chang-Hun,YOUN, Sang-Woong,PARK, Kyoung-Chan Wiley (Blackwell Publishing) 2010 The Journal of Dermatology Vol.37 No.4
<P>Abstract Melasma is an acquired pigmentary disorder that most commonly occurs in women of child-bearing age. Melasma is therapeutically challenging, and most commercially available hypopigmenting agents include tyrosinase inhibitors, which regulate the rate-limiting step of melanogenesis. 4-n-Butylresorcinol has received considerable attention as a novel hypopigmenting agent in the last 15 years because it has an inhibitory effect against tyrosinase and tyrosinase-related protein-1. However, the hypopigmenting effect of 4-n-butylresorcinol in human subjects has only been shown in a few studies. Liposome encapsulation is known to improve stabilization and enhance penetration of the product. Therefore, this study was conducted to evaluate the hypopigmenting efficacy and safety of liposome-encapsulated 4-n-butylresorcinol 0.1% cream in patients with melasma. This was a randomized, double-blind, vehicle-controlled and split-face comparison study. Twenty-three patients with a clinical diagnosis of melasma were included. 4-n-Butylresorcinol 0.1% cream or vehicle was applied to each side of the face twice daily for 8 weeks. Clinical and photographic evaluations, Mexameter measurements and assessment of patient satisfaction and side-effects were performed at baseline, 4 and 8 weeks. All subjects completed the study. Mexameter measurements demonstrated that the melanin index of the 4-n-butylresorcinol-treated side showed a significant decrease when compared with the vehicle-treated side after 8 weeks (P = 0.043). No adverse reactions were observed throughout the study. Subjectively, 4-n-butylresorcinol was considered to be efficacious in more than 60% of the patients after 8 weeks of treatment. In conclusion, liposome-encapsulated 4-n-butylresorcinol 0.1% cream was well tolerated and showed significant higher efficacy than vehicle alone for the treatment of melasma.</P>
나정임 ( Jung-im Na ),박정태 ( Jung Tae Park ),김보리 ( Bo Ri Kim ),김인수 ( In Su Kim ),최지웅 ( Woong Choi ),황영지 ( Young Ji Hwang ),신정원 ( Jung-won Shin ),허창훈 ( Chang Hun Huh ) 대한피부과학회 2016 대한피부과학회지 Vol.54 No.4
Carbon dioxide (CO2) laser is one of the most widely used lasers in dermatology. CO2 laser can precisely ablate the skin with good hemostasis, which makes it an ideal surgical laser. With the development of pulsed CO2 laser, which enabled cleaner ablation with less residual thermal damage, CO2 laser resurfacing became the gold standard for skin rejuvenation. The rejuvenation effect of full-face CO2 laser resurfacing is unparalleled to other methods; however, it is associated with a relative high incidence of side effects and prolonged downtime. Fractional CO2 laser was developed to overcome this problem. With a new technology of fractionating the laser beam into hundreds of microbeams, fractional CO2 laser resurfacing can improve various skin conditions including skin laxity, photodamage, and acne scars with short downtime and significantly lesser side effects. For optimal treatment results, clinicians have to decide the treatment depth and density based on proper understanding of the laser tissue interaction and underlying skin conditions. (Korean J Dermatol 2016;54(4):233~240)
( Sun Young Huh ),( Jung Won Shin ),( Jung Im Na ),( Chang Hun Huh ),( Sang Woong Youn ),( Kyoung Chan Park ) 대한피부과학회 2010 Annals of Dermatology Vol.22 No.1
Background: Melasma is a common acquired symmetrical hypermelanosis that occurs on sun-exposed areas, and it is frequently observed among women. Various treatment modalities have been tried, but none are completely satisfactory. 4-n-butylresorcinol, which is a resorcinol derivative that has an inhibitory effect on both tyrosinase and tyrosinase-related protein-1, was introduced in 1995 and it has received increasing attention as a new hypopigmenting agent. However, the hypopigmenting effect of 4-n-butylresorcinol in human subjects has only been shown in a few studies. Objective: The aim of this study was to investigate the hypopigmenting efficacy and safety of 4-n-butylresorcinol 0.1% cream for the treatment of melasma. Methods: Twenty patients with melasma were enrolled to this randomized, double-blind, vehicle-controlled, split-face comparative study. The patients were instructed to apply 4-n-butylresorcinol 0.1% cream or vehicle to each side of the face twice daily for 8 weeks. Mexameter measurements were performed along with photography at baseline, 4 weeks and 8 weeks. Adverse events were observed and recorded throughout the study. Results: All the patients completed the study. Mexameter measurements demonstrated that the melanin index of the treated side showed a significant decrease when compared with that of the vehicle-treated side after 4 weeks (p=0.006) and after 8 weeks (p<0.0005). All the adverse reactions were mild and transient. Conclusion: 4-n-butylresorcinol 0.1% cream showed rapid efficacy and it was well tolerated when used for the treatment of melasma. (Ann Dermatol 22(1) 21∼25, 2010)
( Jung Im Na ),( Sang Young Byun ),( Mi Young Jeong ),( Kyoung Chan Park ),( Chang Hun Huh ) 대한피부과학회 2014 Annals of Dermatology Vol.26 No.6
Background: Formaldehyde (FA) and other volatile organic compounds (VOCs) are considered among the main causes of atopic aggravation. Their main sources include wallpapers, paints, adhesives, and flooring materials. Objective: To assess the effects of environmentally friendly wallpaper and flooring material on indoor air quality and atopic dermatitis severity. Methods: Thirty patients with atopic dermatitis were enrolled in this study. To improve air quality, the wallpaper and flooring in the homes of the subjects were replaced with plant- or silica-based materials. The indoor air concentration of FA and the total VOCs (TVOCs) were measured before remodeling and 2, 6, and 10 weeks thereafter. Pruritus and the severity of atopic eczema were evaluated by using a questionnaire and the eczema area and severity index (EASI) score before and at 4, 8, and 12 weeks after remodeling. The subjects were instructed to continue their therapy for atopic dermatitis. Results: The houses of 24 subjects were remodeled; all subjects completed the study. The concentration of FA in ambient air significantly decreased within 2 weeks after remodeling. The TVOC level showed a decrease at week 2 but increased again at weeks 6 and 10. The reduction of pruritus and EASI score was statistically significant in patients whose baseline EASI score was >3. Conclusion: Replacing the wallpaper and flooring of houses with environmentally friendly material reduced FA in ambient air and improved pruritus and the severity of atopic eczema. The improvement of pruritus and eczema was statistically significant in patients whose baseline EASI score was >3. (Ann Dermatol 26(6) 688∼692, 2014)
재활승마가 뇌병변 장애아동들의 대동작 운동기능과 균형성에 미치는 효과
임재현(Im, Jae-Hyun),허정훈(Huh, Jung-Hoon) 한국체육과학회 2013 한국체육과학회지 Vol.22 No.3
The purpose of this study was to investigate the effects of rehabilitation horse riding on the gross motor function and muscle balance of mentally disabled children. Six mentally disable children (boys and girls) were selected for this study. Each of the subjects participated in 12 sessions of rehabilitation horse riding over a period of 3 months. Before and after measurements were taken using the gross motor function evaluation, pediatric balance scale and observation techniques. The gross motor function evaluation score was higher after the training for the subject A lying down more and flipping over, for B standing on all fours and kneeling, for E and F sitting down, and for C and D standing. There was a slight difference in the improvement of muscle balance while the subjects were walking. From observation the training affected all of subjects’ psychological state. In conclusion, this study provides evidence that rehabilitation horse riding have positive effects on gross motor function skills of mentally disabled children.
강직척추염 환자의 대동맥 탄력성의 변화, 유병기간과 BASDAI 사이의 연관성
김현정 ( Hyun Jung Kim ),이지현 ( Ji Hyun Lee ),허정은 ( Jung Eun Huh ),최성원 ( Seong Won Choi ),최재원 ( Jae Won Choi ),박근모 ( Keun Mo Park ),조경임 ( Kyung Im Cho ) 대한류마티스학회 2008 대한류마티스학회지 Vol.15 No.3
Objective: Cardiac manifestations are well recognized complication of ankylosing spondylitis (AS). They include aortic incompetence, conduction defects, mitral valve disease, pericarditis and cardiomyopathy. There was one study to evaluate the change of aortic elasticity in AS patient and the association between the aortic strain and duration of AS, Bath Ankylosing Spondylitis Disease Activity Index (BASDAI). We designed this study to determine whether aortic elasticity changes in Korean AS patients and is associated with the duration of AS or BASDAI. Methods: 18 AS patients without cardiovascular involvement and 18 sex and age-matched healthy subjects were enrolled in the study. Aortic strain and distensibility was calculated from aortic diameters measured by echocardiography and blood pressure measured by sphygmomanometry. Results: The mean aortic strain and mean aortic distensibility in AS group indicated that there was not any correlation with those of control group, based on the statistical analysis. Moreover, there was no statistical correlation between the means of aortic strain, aortic distensibility and the duration or BASDAI of AS. Conclusion: In patients with AS without cardiac involvement, the aortic elasticity was not decreased than that of control group, and aortic strain and distensibility were not correlated with the duration or BASDAI of AS.