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오늘 본 자료
Jun Zhang,Yanhui Guo,Weiwei Lu,Xuming Guo,Mingchen Xu,Hongbo Guo 한국공업화학회 2012 Journal of Industrial and Engineering Chemistry Vol.18 No.5
Highly dispersive ammonium dimolybdate crystals with high purity have been prepared through reaction–evaporation–crystallization united route using commercial molybdenum oxide as starting material. The as-prepared ammonium dimolybdate uniform crystals were systematically characterized by X-ray powder diffraction, transmission-reflection optical microscope, Fourier transform infrared spectroscopy and TG-DSC thermal analysis. The Fsss grain diameter, loose packed density, and crystal-grain size distribution were also measured by the Malvern laser particle sizer. These collective characterization and analysis reveal that the ammonium dimolybdate grains are non-agglomerated uniform crystals with well normal distribution and geometric shape. The average Fsss diameter, d(0.5) and loose packed density are 433.316 mm, 470.981 mm and 1.592 g cm3, respectively, which could well meet the quality requirements for the subsequent production of molybdenum powders.
Conversion of syngas to C2+ oxygenates over Rh-based/SiO2 catalyst: The promoting effect of Fe
Jun Yu,Dongsen Mao,Lupeng Han,Qiangsheng Guo,Guanzhong Lu 한국공업화학회 2013 Journal of Industrial and Engineering Chemistry Vol.19 No.3
The effect of Fe promoter on the catalytic properties of Rh–Mn–Li/SiO2 catalyst for CO hydrogenation was investigated. The catalysts were comprehensively characterized by means of X-ray diffraction (XRD), N2adsorption–desorption, temperature programmed reduction (TPR), temperature programmed desorption (TPD), temperature programmed surface reaction (TPSR), and diffuse reflectance infrared Fourier transform spectroscopy (DRIFTS). Activity testing results showed that low loading of Fe (≤0.1 wt%)improved the reactivity and yield of C2+ oxygenates; however, the opposite effect appeared at the high values of Fe (>0.1 wt%). Characterization results suggested that the addition of Fe strengthened the Rh–Mn interaction and increased the desorption/transformation rate of adsorbed CO, which could be responsible for the increase of CO conversion. But on the other hand, the existence of Fe might deposit over the Rh surface, and decreased the number of active sites, resulting in the decrease of CO conversion when the Fe amount was excessive. The selectivity to C2+ oxygenates varied inversely with the reducibility of Rh oxide species. Moreover, it is proposed that the transformation of dicarbonyl Rh+(CO)2into H–Rh–CO is favorable for the formation of C2+ oxygenates, and the hydrogenation ability of Fe can increase the hydrogenation of acetaldehyde to ethanol.
( Guo Jun Lang ),( Ming Yan Zhang ),( Bao Ling Li ),( Lin Lin Yu ),( Xing Meng Lu ),( Chuan Xi Zhang ) 생화학분자생물학회 (구 한국생화학분자생물학회) 2010 BMB Reports Vol.43 No.8
Several organophosphorus (OP) insecticides can selectively kill the silkworm maggot, Exorista sorbillans (Es) (Diptera: Tachinidae), while not obviously affecting the host (Bombyx mori) larvae, but the mechanism is not yet clear. In this study, the cDNA encoding an acetylcholinesterase (AChE) from the field Es was isolated. One point mutation (Gly353Ala) was identified. The Es-353G AChE and Es-353A AChE were expressed in baculovirus- insect cell system, respectively. The inhibition results showed that for eserine and Chlorpyrifos, Es-353A AChE was significantly less sensitive than Es-353G AChE. Meanwhile, comparison of the I(50) values of eserine, dichlorvos, Chlorpyrifos and omethoate of recombinant Es AChEs with its host (Bombyx mori) AChEs indicated that, both Es AChEs are more sensitive than B. mori AChEs. The results give an insight of the mechanism that some OP insecticides can selectively kills Es while without distinct effect on its host, B. mori. [BMB reports 2010; 43(8): 573-578]
LU ZHANG,Peihui Yang,YAN-JIE GUO,JIAN-JUN LUO,GUI-MIN SUN,ZHI-HONG LIANG,YAN-JUAN TANG 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2014 NANO Vol.9 No.3
A novel core – shell hybrid nanostructure was constructed by employing gold nanorod (AuNR)combined with rhodamine B (RB) as a core and silica as a shell. The poly(sodium 4-styr-enesulfonate) (PSS), a negatively charged polyelectrolyte, played the role of linker to electro-statically trap RB on AuNRs. Due to the °uorescence spectral overlap between RB and AuNRs at560 nm, the red °uorescence and enhanced green °uorescence of the hybrid nanostructures wereobserved obviously, which is capable for dual-color labeling. To reduce toxic side e®ects ofAuNRs, silica was coated on AuNRs as a shell to fabricate the novel core – shell hybrid nano-structure function as a dual-color labeling for cancer-cell imaging. The fabricated compositestructures were characterized by transmission electron microscopy (TEM), absorption spectrum,°uorescence spectrum, zeta potential measurements and laser scanning confocal microscope(LSCM). The experiment results con¯rmed that the obtained hybrid nanostructures providedexcellent photostability, biocompatibility and active surface for further biological functionali-zation. The novel composite structures may have great potential application in cell multicolorlabeling and imaging instead of traditional °uorescent dyes.
SLAMF7 is critical for phagocytosis of haematopoietic tumour cells via Mac-1 integrin
Chen, Jun,Zhong, Ming-Chao,Guo, Huaijian,Davidson, Dominique,Mishel, Sabrin,Lu, Yan,Rhee, Inmoo,Pé,rez-Quintero, Luis-Alberto,Zhang, Shaohua,Cruz-Munoz, Mario-Ernesto,Wu, Ning,Vinh, Donald C.,Si Nature Publishing Group 2017 Nature Vol. No.
<P>Cancer cells elude anti-tumour immunity through multiple mechanisms, including upregulated expression of ligands for inhibitory immune checkpoint receptors(1,2). Phagocytosis by macrophages plays a critical role in cancer control(3-6). Therapeutic blockade of signal regulatory protein (SIRP)-alpha, an inhibitory receptor on macrophages, or of its ligand CD47 expressed on tumour cells, improves tumour cell elimination in vitro and in vivo(7-10), suggesting that blockade of the SIRP alpha-CD47 checkpoint could be useful in treating human cancer(11-14). However, the prophagocytic receptor(s) responsible for tumour cell phagocytosis is(are) largely unknown. Here we find that macrophages are much more efficient at phagocytosis of haematopoietic tumour cells, compared with non-haematopoietic tumour cells, in response to SIRP alpha-CD47 blockade. Using a mouse lacking the signalling lymphocytic activation molecule (SLAM) family of homotypic haematopoietic cell-specific receptors, we determined that phagocytosis of haematopoietic tumour cells during SIRP alpha-CD47 blockade was strictly dependent on SLAM family receptors in vitro and in vivo. In both mouse and human cells, this function required a single SLAM family member, SLAMF7 (also known as CRACC, CS1, CD319), expressed on macrophages and tumour cell targets. In contrast to most SLAM receptor functions(15-17), SLAMF7-mediated phagocytosis was independent of signalling lymphocyte activation molecule-associated protein (SAP) adaptors. Instead, it depended on the ability of SLAMF7 to interact with integrin Mac-1 (refs 18-20) and utilize signals involving immunoreceptor tyrosine-based activation motifs(21,22). These findings elucidate the mechanism by which macrophages engulf and destroy haematopoietic tumour cells. They also reveal a novel SAP adaptor-independent function for a SLAM receptor. Lastly, they suggest that patients with tumours expressing SLAMF7 are more likely to respond to SIRP alpha-CD47 blockade therapy.</P>
Proteomic Analysis of the Triglyceride-Rich Lipoprotein-Laden Foam Cells
Yanjun Lu,Jianli Guo,Yong Di,Yiqiang Zong,Shen Qu,Jun Tian 한국분자세포생물학회 2009 Molecules and cells Vol.28 No.3
In hypertriglyceridaemic individuals, atherosclerogenesis is associated with the increased concentrations of very low density lipoprotein (VLDL) and VLDL-associated rem-nant particles. In vitro studies have suggested that VLDL induces foam cells formation. To reveal the changes of the proteins expression in the process of foam cells formation induced by VLDL, we performed a proteomic analysis of the foam cells based on the stimulation of differentiated THP-1 cells with VLDL. Using two-dimensional gel electro-phoresis (2-DE) and matrix-assisted laser-desorption ioni-zation time-of-flight mass spectrometry (MALDI-TOF MS) analysis, 14 differentially expressed proteins, containing 8 up-regulated proteins and 6 down-regulated proteins were identified. The proteins are involved in energy metabolism, oxidative stress, cell growth, differentiation and apoptosis, such as adipose differentiation-related protein (ADRP), enolase, S100A11, heat shock protein 27 and so on. In addition, the expression of some selected proteins was confirmed by Western blot and RT-PCR analysis. The re-sults suggest that VLDL not only induces lipid accumula-tion, but also brings about foam cells diverse characteris-tics by altering the expression of various proteins.