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Modeling refractory concrete lining of fluid catalytic cracking units of oil refineries
Ana B.C.G. Silva,Henrique C.C. Andrade,Eduardo M.R. Fairbairn,Jose C.F. Telles,Fernando L.B. Ribeiro,Romildo D. Toledo-Filho,Jorivaldo Medeiros 사단법인 한국계산역학회 2020 Computers and Concrete, An International Journal Vol.25 No.1
This work presents a numerical modeling procedure to simulate the refractory concrete lining in fluid catalytic cracking units of oil refineries. The model includes the simulation of the anchors that reinforce the contact between the refractory concrete and the steel casing. For this purpose, the constitutive relations of an interface finite element are set to values that represent the homogenized behavior of the anchored interface. The parameters of this constitutive relation can be obtained by experimental tests. The model includes also multi-surface plasticity, in order to represent the behavior of the refractory concrete lining. Since the complexity of real case applications leads to high computational costs, the models presented here were implemented in a high-performance parallelized finite element platform. A case study representing a riser similar to the ones used by the refinery industry demonstrates the potential of the model.
A general tangent operator applied to concrete using a multi-surface plasticity model
Ana Beatriz C.G. Silva,Jose Claudio F. Telles,Eduardo M.R. Fairbairn,Fernando Luiz B. Ribeiro 사단법인 한국계산역학회 2015 Computers and Concrete, An International Journal Vol.16 No.2
The present paper aims at developing a method to accommodate multi-surface concrete plasticity from the point of view of a consistency concept applied to general tangent operators. The idea is based on a Taylor series expansion of the actual effective stress at the stress point corresponding to the previous accumulated true stresses plus the current increment values, initially taken to be elastic. The proposed algorithm can be generalized for any multi-surface criteria combination and has been tested here for typical cement-based materials. A few examples of application are presented to demonstrate the effectiveness of the multi-surface technique as used to a combination of Rankine and Drucker-Prager yield criteria.
Original Article : Influence of P53 on the radiotherapy response of hepatocellular carcinoma
( Ana R. Gomes ),( Ana M. Abrantes ),( Ana F. Brito ),( Mafalda Laranjo ),( Joao E. Casalta Lopes ),( Ana C. Goncalves ),( Ana B. Sarmento Ribeiro ),( Maria F. Botelho ),( Jose G. Tralhao ) 대한간학회 2015 Clinical and Molecular Hepatology(대한간학회지) Vol.21 No.3
Background/Aims: Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide, and it has a poor prognosis and few therapeutic options. Radiotherapy is one of the most effective forms of cancer treatment, and P53 protein is one of the key molecules determining how a cell responds to radiotherapy. The aim of this study was to determine the therapeutic effi cacy of iodine-131 in three human HCC cell lines. Methods: Western blotting was used to measure P53 expression. The effects of radiotherapy with iodine-131 were assessed by using the clonogenic assay to evaluate cell survival. Flow cytometry was carried out to examine the effectsof iodine-131 on cell death, oxidative stress, reduced intracellular glutathione expression, the mitochondrial membrane potential, and the cell cycle. Results: The P53 protein was not expressed in Hep3B2.1-7 cells, was expressed at normal levels in HepG2 cells, and was overexpressed in HuH7 cells. P53 expression in the HuH7 and HepG2 cell lines increased after internal and external irradiation with iodine-131. Irradiation induced a decrease in cell survival and led to a decrease in cell viability in all of the cell lines studied, accompanied by cell death via late apoptosis/necrosis and necrosis. Irradiation with 131-iodine induced mostly cell-cycle arrest in the G0/G1 phase. Conclusions: These results suggest that P53 plays a key role in the radiotherapy response of HCC. (Clin Mol Hepatol 2015;21:257-267)