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What’s new in dermatopathology 2023: WHO 5th edition updates
Ho Jonathan,Chico J Collie 대한병리학회 2023 Journal of Pathology and Translational Medicine Vol.57 No.6
The 5th edition WHO Classification of Skin Tumors (2022) has introduced changes to nomenclature and diagnostics. Important differences are discussed below. Changes in each category of skin tumor have been detailed, with particular emphasis on meaningful advances in our understanding of the molecular pathogenesis of the skin’s diverse tumor landscape.
Flexible Fibrous Piezoelectric Sensors on Printed Silver Electrodes
Ho Yeon Son,Jae Sung Park,Huang, Jonathan,Jiseok Kim,Yoon Sung Nam,Woo Soo Kim IEEE 2014 IEEE TRANSACTIONS ON NANOTECHNOLOGY Vol.13 No.4
<P>Here, we report a facile fabrication of flexible piezoelectric sensors based on highly aligned poly(vinylidene fluoride) (PVDF) nanofibers and printed silver electrodes without any additional poling processes. One-dimensional (1-D) piezoelectric PVDF nanofibers are directly produced onto stamped and sprayed interdigitated electrodes by electrospinning. We studied here the effect of contact area between nanofibers and electrodes by controlling the surface roughness of electrode. PVDF sensors show increased piezoelectric responses with larger actual contact area of the interdigitated electrodes. The measured output voltage under periodic bending stress is up to about 1 V. It is expected that this facile method to fabricate the PVDF sensors can be used to integrate the energy harvesters into flexible and stretchable functional electronic devices.</P>
Unit Cell FEM Analysis Using I-Fiber Single Stitch with Different Thickness
( Jonathan Tapullima ),( Gyu Yeong Park ),( Dong Hwan Yoon ),( Jin Ho Choi ) 한국복합재료학회 2021 Composites research Vol.34 No.1
This paper present a three-dimensional unit cell finite element analysis to predict the pull-out behavior of a single stitch in a composite laminate. The stitching process used for this study correspond to the I-fiber stitching method that has been studied by the Composite Structures Lab (CSL) as a new through-thickness reinforced method. A total of six cases were analyzed, which were divided in two groups by the stitching yarn used, 6k and 12k. Each group of cases have three different thickness according to the amount of plies; 16 plies, 32 plies and 64 plies. The finite element analysis used the cohesive zone method to characterize the single stitch reinforcement in the interface. Due to the complexity of the load vs displacement curves taken from the experimental results, a bilinear and trilinear bridging laws were implemented in the models. The cohesive parameters used for each case showed a good agreement with the experimental data and can be used for future studies.
Ho, I-Ting,Zhang, Zhan,Ishida, Masatoshi,Lynch, Vincent M.,Cha, Won-Young,Sung, Young Mo,Kim, Dongho,Sessler, Jonathan L. American Chemical Society 2014 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY - Vol.136 No.11
<P>Reported here is a new hybrid macrocycle, cyclo[1]furan[1]pyridine[4]pyrrole (<B>1</B>), that bears analogy to the previously reported mixed heterocycle system cyclo[2]pyridine[4]pyrrole (<B>2</B>) and cyclo[6]pyrrole <B>3</B>, an all-pyrrole 22 π-electron aromatic expanded porphyrin. The oxidized, dianionic form of <B>1</B>, [<B>1</B> – 4H]<SUP>2–</SUP>, has been characterized as its uranyl complex. In contrast to <B>2</B> and <B>3</B> and in spite of the presence of a 2,6-disubstituted pyridine subunit, the uranyl complex of [<B>1</B> – 4H]<SUP>2–</SUP> displays solid-state structural and solution-phase spectroscopic features consistent with contributions to the overall electronic structure that involve a conjugated, (4<I>n</I> + 2) π-electron aromatic periphery.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jacsat/2014/jacsat.2014.136.issue-11/ja412520g/production/images/medium/ja-2013-12520g_0014.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/ja412520g'>ACS Electronic Supporting Info</A></P>
Contemporary Interventional Approach to Calcified Coronary Artery Disease
Jonathan Gabriel Sung,Sidney TH Lo,Ho Lam 대한심장학회 2023 Korean Circulation Journal Vol.53 No.1
Calcific coronary artery disease is an increasingly prevalent entity in the catheterization laboratory which has implications for stenting and expected outcomes. With new interventional techniques and equipment, strategies to favorably modify coronary calcium prior to stenting continue to evolve. This paper sought to review the latest advances in the management of severe coronary artery calcification in the catheterization laboratory and discuss contemporary percutaneous interventional approaches.
Tsui, Jonathan H.,Janebodin, Kajohnkiart,Ieronimakis, Nicholas,Yama, David M. P.,Yang, Hee Seok,Chavanachat, Rakchanok,Hays, Aislinn L.,Lee, Haeshin,Reyes, Morayma,Kim, Deok-Ho American Chemical Society 2017 ACS NANO Vol.11 No.12
<P>Despite possessing substantial regenerative capacity, skeletal muscle can suffer from loss of function due to catastrophic traumatic injury or degenerative disease. In such cases, engineered tissue grafts hold the potential to restore function and improve patient quality of life. Requirements for successful integration of engineered tissue grafts with the host musculature include cell alignment that mimics host tissue architecture and directional functionality, as well as vascularization to ensure tissue survival. Here, we have developed biomimetic nanopatterned poly(lactic-<I>co</I>-glycolic acid) substrates conjugated with sphingosine-1-phosphate (S1P), a potent angiogenic and myogenic factor, to enhance myoblast and endothelial maturation. Primary muscle cells cultured on these functionalized S1P nanopatterned substrates developed a highly aligned and elongated morphology and exhibited higher expression levels of myosin heavy chain, in addition to genes characteristic of mature skeletal muscle. We also found that S1P enhanced angiogenic potential in these cultures, as evidenced by elevated expression of endothelial-related genes. Computational analyses of live-cell videos showed a significantly improved functionality of tissues cultured on S1P-functionalized nanopatterns as indicated by greater myotube contraction displacements and velocities. In summary, our study demonstrates that biomimetic nanotopography and S1P can be combined to synergistically regulate the maturation and vascularization of engineered skeletal muscles.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/ancac3/2017/ancac3.2017.11.issue-12/acsnano.7b00186/production/images/medium/nn-2017-001868_0008.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/nn7b00186'>ACS Electronic Supporting Info</A></P>