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RISS 인기검색어
- 검색키워드
- 저자 : Elizabethe A. Esteves (검색결과 2 건)
- 무료
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Modified Soybean Affects Cholesterol Metabolism in Rats Similarly to a Commercial Cultivar
Elizabethe A. Esteves,Josefina Bressan,Neuza M.B. Costa,Hercia S.D. Martino,Shawn S. Donkin,Jon A. Story 한국식품영양과학회 2011 Journal of medicinal food Vol.14 No.11
The consumption of soy protein lowers blood cholesterol in humans and animals. Breeding may alter the physiological effects of soybeans, such as its cholesterol-lowering property. Our hypothesis is that breeding affects the hypocholesterolemic effect of soy by modulating the expression of key hepatic enzymes related to cholesterol and bile acid biosynthesis, as well as altering fecal neutral and acidic steroid excretion. Therefore the aim of this study was to evaluate the effect of a new Brazilian soybean cultivar (UFV-116), lacking lipoxygenases 2 and 3, compared with a commercial cultivar (OCEPAR-19), on 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGR) and cholesterol 7α-hydroxylase (CYP7A) mRNA expression and fecal steroid output in rats. Thirty-six male rats were fed UFV-116, OCEPAR-19, or casein as the protein source, with or without addition of dietary cholesterol (0.25%). Blood and liver cholesterol, HMGR and CYP7A mRNA abundance, and fecal excretion of steroids were measured. Blood and liver cholesterol levels were lowered by both soybean cultivars, with and without cholesterol, but UFV-116 was more effective when included in the cholesterol-free diet. Both soy diets promoted lower levels of HMGR mRNA, higher levels of CYP7A mRNA, and higher excretion of fecal secondary bile acids. There was higher fecal neutral steroid output when cholesterol was added to all diets. These data show that both soybean cultivars acted similarly in lowering serum and hepatic cholesterol; therefore, breeding did not affect the hypocholesterolemic effect of the new cultivar.
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Myrciaria cauliflora Peel Flour Had a Hypolipidemic Effect in Rats Fed a Moderately High-Fat Diet
Clina´scia R.R. Arau´jo,Elizabethe A. Esteves,Nísia A.V. Dessimoni-Pinto,Ângela G. Batista 한국식품영양과학회 2014 Journal of medicinal food Vol.17 No.2
The aim of this study was to evaluate the hypolipidemic effects of Myrciaria cauliflora peel flour (MPF) in rats. Previously, it was determined the proximate composition, total phenolics, and anthocyanins of MPF. Then, groups of male rats were randomly assigned to one of the five treatment groups. The standard group received a basal diet as recommended by the American Institute of Nutrition (AIN93M). The control group (CTRL) received the AIN93M diet, which added 7% of pork lard. The jaboticaba groups had their diets similar to CTRL, but added MPF at 7 ( JAB1), 10 ( JAB2), or 15% ( JAB3). Serum and liver cholesterol as well as serum levels of high-density lipoprotein (HDL), triglycerides (TG), and glucose were evaluated. Fecal output of lipids was also measured. MPF had expressive amounts of fibers (25.28 – 2.52 g/ 100 g), total phenolics (18.95 – 5.27 mg/100 g), and anthocyanins (6.82 – 0.18 mg/100 g). The inclusion of the MPF at three ratios, reduced serum cholesterol and TG compared with CTRL. JAB3 raised serum HDL and reduced liver cholesterol compared with CTRL. JAB3 and JAB2 reduced serum glucose compared with CTRL. JAB groups eliminated more feces and had pH values lower than CTRL. However, there was no difference in lipid fecal output between all groups. MPF has a hypolipidemic potential, especially on reducing serum cholesterol and TG. These effects can be attributed, at least in part, to its fiber and phenolic composition.
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