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Dong Liu,Xiaoying Du,Jianping Deng,Wantai Yang 한국고분자학회 2011 Macromolecular Research Vol.19 No.7
Optically active gels based on helical N-propargylamide polymers were prepared using a one-pot twostep methodology: the pre-formation of helical N-propargylamide copolymer (defined as N=N-HP) and the preparation of gels bearing the helical copolymers. To prepare N=N-HP, N-propargylamide M1, which contained -N=Nfunctional group, and M2, which provided helical polymer chains for the resulting copolymers, underwent copolymerizations in the presence of (nbd)Rh^+B^-(C_6H_5)_4 as a catalyst. -N=N- groups in N=N-HP acted as an initiator to induce the free radical polymerization of styrene, yielding the designed gels. Trimethylol propane triacrylate (TMPTA) was used to improve the cross-linking degree of the gels. The obtained gels were characterized by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and circular dichroism (CD) spectroscopy measurements. The gels showed high optically activity, resulting from the helical structures of the N-propargylamide polymer chains. Preferential adsorption towards (R)-(+)-1-phenylethylamine in the two enantiomers was observed in the obtained gels, demonstrating the potentials of such gels in chiral recognition and chiral resolution.
Tang, Jianping,Li, Qian,Wang, Shuyu,Lee, Dong‐,Kyou,Hui, Pinhong,Niu, Xiaorui,Gutowski Jr., William J.,Dairaku, Koji,McGregor, John,Katzfey, Jack,Gao, Xuejie,Wu, Jia,Hong, Song‐,You,Wang, Wiley 2016 International journal of climatology Vol.36 No.13
<P><B>ABSTRACT</B></P><P>Under the Asia‐Pacific Network for Global Change (APN) project ‘Building Asian Climate Change Scenarios by Multi‐Regional Climate Models Ensemble’ (RMIP III, Regional Model Intercomparision Project), the simulation results of eight regional climate models (RCMs) and two fine‐resolution global climate models are validated for reproducibility of the current surface air temperature climatology (1981–2000), and are used to generate surface air future temperature projections (2041–2060) over the CORDEX‐EA (A Coordinated Regional climate Downscaling Experiment‐East Asia) domain. Four ensemble methods, namely, the equal weighting, the weighted mean, the reliability ensemble averaging, and the performance‐based ensemble averaging, are employed to generate the multi‐model projection of regional climate change over the region. The results show that the regional temperature ensembles of the present climate obtained from all four methods can outperform a single RCM result in aspects of the spatial distribution as well as the seasonal variation over East Asia. The four ensemble methods are then used to project the regional temperature climatology under the IPCC emission scenario of A1B for 2041–2060. Compared with the control climate of 1981–2000, the annual mean temperature of the future climate (2041–2060) increases 1–2 °C in low latitude areas and 2–3 °C in middle–high latitude areas over Asia.</P>
Jiang, Renfang,Dong, Jianping,Joo, Jungnam,Geller, Nancy L,Zheng, Gang Macmillan Publishers Limited 2011 European journal of human genetics Vol.19 No.7
For haplotype analysis of the X chromosome, haplotype-sharing (HS) statistics with sliding windows are defined for males and females separately, which are then combined to a single HS test for the X chromosome. When independent replication samples are not available, the training-testing sets approach is used to validate this procedure and a permutation method is used to obtain its P-value. We applied this method to the X chromosome (with 1804 SNPs) for age-related macular degeneration (AMD). We found a window of five SNPs over a 272 kb region associated with AMD after Bonferroni correction. An examination of the odds ratio and the population attributable risks revealed a disease-preventive haplotype, ATGAC, on these five SNPs. For elderly females without this haplotype, the likelihood of AMD is increased by a factor of 4.75 with a 95% confidence interval (1.43, 15.82). The frequency of ATGAC in HapMap CEU is 0.276. These five SNPs are covered by the gene DIAPH2, which is known to cause premature ovarian failure (POF) in females. Our results indicated that DIAPH2 may be a polygenic pleiotropy for POF and AMD.
Dasheng Li,Dawei Wang,Jianping Dong,Nana Wang,He Huang,Haiwang Xu,Chen Xia 대한영상의학회 2020 Korean Journal of Radiology Vol.21 No.4
The epidemic of 2019 novel coronavirus, later named as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is still gradually spreading worldwide. The nucleic acid test or genetic sequencing serves as the gold standard method for confirmation of infection, yet several recent studies have reported false-negative results of real-time reverse-transcriptase polymerase chain reaction (rRT-PCR). Here, we report two representative false-negative cases and discuss the supplementary role of clinical data with rRT-PCR, including laboratory examination results and computed tomography features. Coinfection with SARS-COV-2 and other viruses has been discussed as well.
Daojie Wang,Cuiling Yang,Long Dong,Jiacheng Zhu,Jianping Wang,Shufeng Zhang 한국식물학회 2015 Journal of Plant Biology Vol.58 No.4
Brassica napus is a dicotyledonous plant in the family Brassicaceae. It is an important oil crop which has been widely cultivated over the world. However, drought stress is a very important threatening to B. napus production. In this study, two B. napus strains with different resistance to drought stress were treated with 200 g/L PEG-6000 as drought simulation agent (marked as S, R)and two controls were treated with 1/2 Hoagland medium(marked as ST, RT). With the help of Illumina paired-end RNA-seq technology and de novo assembly by Trinity, we obtained 107,294 Unigenes (integrated four sample results) with an average length of 834 bp and N50 1245. Of these Unigenes, 84,768, 92,545, 54,857, 28,129, 75,278 were assigned to NR, NT, Swiss-Prot, COG and GO database respectively. A total of 46,861 were mapped to 128 pathways by BLAST comparison against the KEGG database. In order to have an overall understanding of the unique genes’ expression difference among four samples, we utilized RPKM to calculate Unigene expression, and to identify differentially expressed genes. Besides, 22,414 SSRs were developed in this study.
David Jiyao Chou,Kelly Yinching Lam,Jianping Chen,Ping Yao,Tina Tingxia Dong,Aizhen Xiong,Guixin Chou,Zhengtao Wang,Karl Wah-Keung Tsim 셀메드 세포교정의약학회 2014 셀메드 (CellMed) Vol.4 No.4
Linderae Radix, the dry roots of Lindera aggregata (Sims) Kosterm, has long been used as traditional Chinese medicine for treatment of inflammatory diseases. The total alkaloids are believed to be the active components responsible for anti-inflammation of Linderae Radix. Here, the total alkaloids of Linderae Radix were extracted and isolated, including 12 isoquinoline alkaloids and 1 furan sesquiterpene. Within the alkaloids, norisoboldine, boldine, linderaline, isoboldine, reticuline, N-methyllaurotetanine, norjuziphine were found to be the major ingredients. In lipopolysaccharide-treated macrophage RAW 264.7 cells, application of Linderae Radix extract, or total alkaloids, suppressed the transcription of pro-inflammatory cytokines, interleukin-1β and interleukin-6. Out of the 12 alkaloids, norisoboldine, boldine, and isoboldine were tested in lipopolysaccharide-treated macrophages, and norisoboldine was the strongest alkaloid in suppressing the cytokine expressions. The current studies suggested that the identification of alkaloids from Linderae Radix could provide a plausible explanation for herbal therapeutic functions.
Li, Qian,Wang, Shuyu,Lee, Dong‐,Kyou,Tang, Jianping,Niu, Xiaorui,Hui, Pinhong,Gutowski Jr., William J.,Dairaku, Koji,McGregor, John L.,Katzfey, Jack,Gao, Xuejie,Wu, Jia,Hong, Song‐,You,Wan Wiley 2016 International journal of climatology Vol.36 No.13
<P><B>ABSTRACT</B></P><P>Under the framework of an project ‘Building Asian Climate Change Scenarios by Multi‐Regional Climate Models Ensemble’, the ability of eight regional climate models and two fine‐resolution global climate models to reproduce late 20th century (1981–2000) precipitation climatology is assessed. Future precipitation change (2041–2060) under the A1B scenario is also quantified by applying four different ensemble methods: equal weighting, weighted mean (WM), reliability ensemble averaging (REA) and performance‐based ensemble averaging, after applying fourfold cross‐validation using observation and multi‐model‐simulated precipitation. The results indicate that the ensemble of simulated precipitation outperforms any single RCM in many aspects. Among the four ensemble approaches, the WM and REA methods show better skill in improving the simulation results, and are used for ensemble prediction of regional climate in Asia. Under the A1B scenario, the WM method estimates future precipitation change of approximately 0.2 mm day<SUP>−1</SUP> with less precipitation in northern and western China and northern India, and more precipitation in most other areas in Asia. The future annual precipitation will decrease by 0.1‐0.5 mm day<SUP>−1</SUP> in northern India, Pakistan and the central area of southern China. No significant change is found over eastern Kazakhstan, Mongolia, north‐central and western China.</P>