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Zhen-Jian Lin,Xiao-Ming Lu,Tian-Jiao Zhu,Yu-Chun Fang,Qian-Qun Gu,Weiming Zhu 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.9
An endophytic Streptomyces sp. (AC-2) was isolated from the root of Cistanches deserticola Y.C.Ma..Chemical investigations of the culture broth of AC-2 afforded fifteen compounds including K1115 A (1), tyrosol (2), phenylethylamine derivatives (3, 4), cyclic dipeptides (5-8), nucleosides and their aglycones (9-13), N-acetyltryptamine (14), and pyrrole-2-carboxylic acid (15). Only tyrosol can promote an increase of intracellular cAMP special on GPR12 transfected cells, such as CHO and HEK293, which means it may be a possible ligand for GPR12.
Lin, Zhen-Jian,Lu, Xiao-Ming,Zhu, Tian-Jiao,Fang, Yu-Chun,Gu, Qian-Qun,Zhu, Weiming 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.9
An endophytic Streptomyces sp. (AC-2) was isolated from the root of Cistanches deserticola Y.C.Ma.. Chemical investigations of the culture broth of AC-2 afforded fifteen compounds including K1115 A (1), tyrosol (2), phenylethylamine derivatives (3, 4), cyclic dipeptides (5-8), nucleosides and their aglycones (9-13), N-acetyltryptamine (14), and pyrrole-2-carboxylic acid (15). Only tyrosol can promote an increase of intracellular cAMP special on GPR12 transfected cells, such as CHO and HEK293, which means it may be a possible ligand for GPR12.
Xu, Hui-Min,Zhu, Jian-Guo,Gu, Lian,Hu, Song-Qun,Wu, Hao Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.4
Vascular endothelial growth factor 2 (VEGFR2) was initially identified as a receptor of VEGF on endothelial cells with a role in regulating angiogenesis during organism development and tumorigenesis. Previously, in cancer tissue, VEGFR2 has been reported to be expressed in endothelial cells. In our research, we found that VEGFR2 was expressed not only in endothelial cells but also cancer cells in head and neck squamous cell carcinomas (HNSCCs). Knockdown of VEGFR2 in Hep2 cells could arrest the cell cycle in G0/G1, leading to a decrease in proliferation. We also present evidence that MAPK/ERK signal pathways and expression of CDK1 downstream of VEGFR2 might regulate proliferation and cell cycle arrest. Furthermore, we discovered that down-regulate VEGRF2 in Hep2 cells could significantly affect the invasion ability. Taken together, our data suggest that VEGFR2 might regulate proliferation and invasion in HNSCC cancer cells in vivo.
Myopericytoma Involving the Parotid Gland as Depicted on Multidetector CT
Zhi-Gang Chu,Jian-Qun Yu,Zhi-Gang Yang,Zhi-Yu Zhu,Hong-Mei Yuan 대한영상의학회 2009 Korean Journal of Radiology Vol.10 No.4
Myopericytoma is a newly proposed subgroup of perivascular tumors in the World Health Organization classification of soft tissue tumors. In this study, we report a case of a benign myopericytoma with detailed multidetector CT (MDCT) findings in the parotid gland, a location that has not been described for this type of tumor previously. The clinical presentation, imaging features, histopathological and immunohistochemical findings, and the differential diagnosis with other tumors in the parotid gland are described and reviewed.
The Application of Built-in Beam Element Method in the Aqueduct Pile Foundation Analysis
Shiyang Pan,Tongchun Li,Xiao Qing Liu,Jian-qun Zhu,Zhen Cui,Zhengyi Wang 대한토목학회 2023 KSCE Journal of Civil Engineering Vol.27 No.7
The solution using built-in beam element method to increase the calculation efficiency of aqueduct pile foundations is studied in this work. The formulations of built-in beam element method based on the normal generalized displacement method of beam element are introduced in this work. Then, the validity of the built-in beam element method is checked by a static problem of a simplified aqueduct model. Furthermore, the solution to increase calculation efficiency by built-in beam element method for aqueduct pile foundations is introduced by studying the features of built-in beam element method and normal generalized displacement method of beam element in models with different grid density and foundation stiffness. Finally, a static problem of an arch aqueduct is solved using the summed solution. The results show that it is feasible to improve efficiency with sufficient accuracy by reasonably selecting the built-in beam element method and normal generalized displacement method in the analysis of aqueduct pile foundation.
Two New Metabolites with Cytotoxicities from Deep-Sea Fungus, Aspergillus sydowi YH11-2
De-Hai Li,Sheng-Xin Cai,Li Tian,Zhen-Jian Lin,Tian-Jiao Zhu,Yu-Chun Fang,Pei-Pei Liu,Qian-Qun Gu,Wei-Ming Zhu 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.9
Two new compounds, 2, 3, 5-trimethyl-6-(3-oxobutan-2-yl)-4H-pyran-4-one (1) and (2R)-2, 3- dihydro-7-hydroxy-6, 8-dimethyl-2-[(E)-prop-1-enyl] chromen-4-one (2), together with six known compounds (3-8), were isolated from a deep-sea fungus, identified as Aspergillus sydowi, by a bioassay-guided method. Their structures were elucidated by spectroscopic methods and the cytotoxicities were evaluated by SRB method.
Seismic Factor of Safety for 3D Reinforced Soil Slope with Piles under Unsaturated Condition
Jia-jing Wei,Hong Liao,Li-Li Liu,Jian-qun Zhu 대한토목학회 2022 KSCE JOURNAL OF CIVIL ENGINEERING Vol.26 No.9
This study investigates the seismic stability of reinforced slope under a three-dimensional (3D) rotational horn-like failure mechanism, using the pseudo-dynamic approach and provides a new procedure to estimate factor of safety (FS) for slope. Such a procedure is able to figure out the influences of the seismic force, the soil property and the reinforcement by piles. Pseudo-dynamic approach is used to describe the seismic force in the time-to-spatial fields in unsaturated soils where matric suction works. Compared to the pseudo-static approach, the current approach considers the effects of time and spatial through the horizontal and vertical shear waves. For the pile driving, different insertion depths can yield various results, whether two work conditions of considering the pile resistance or not are discussed. FS of this study undergoes a decrement as the increase of the pile resistance and seismic force, indicating that the insertion depth affects FS where FS decreases in the early period of pile driving, after that increases and keeps constant in the late of pile driving, showing evident unimodal characteristics during the pile driving. The new expressions for slope reinforced by piles are presented for practical use in unsaturated soil engineering.
Two New Metabolites with Cytotoxicities from Deep-Sea Fungus, Aspergillus sydowi YH11-2
Li, De-Hai,Cai, Sheng-Xin,Tian, Li,Lin, Zhen-Jian,Zhu, Tian-Jiao,Fang, Yu-Chun,Liu, Pei-Pei,Zhu, Wei-Ming,Gu, Qian-Qun 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.9
Two new compounds, 2, 3, 5-trimethyl-6-(3-oxobutan-2-yl)-4H-pyran-4-one (1) and (2R)-2, 3-dihydro-7-hydroxy-6, 8-dimethyl-2-[(E)-prop-1-enyl] chromen-4-one (2), together with six known compounds (3-8), were isolated from a deep-sea fungus, identified as Aspergillus sydowi, by a bioassay-guided method. Their structures were elucidated by spectroscopic methods and the cytotoxicities were evaluated by SRB method.