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Frequency of CYP2C9 alleles in Koreans and their effects on losartan pharmacokinetics
Bae, Jung-woo,Choi, Chang-ik,Kim, Mi-jeong,Oh, Da-hee,Keum, Seul-ki,Park, Jung-in,Kim, Bo-hye,Bang, Hye-kyoung,Oh, Sung-gon,Kang, Byung-sung,Park, Hyun-joo,Kim, Hae-deun,Ha, Ji-hey,Shin, Hee-jung,Kim, Springer Science and Business Media LLC 2011 Acta pharmacologica Sinica. Vol.32 No.10
Laparoscopic repair of delayed rupture of cesarean section scar site occurred 1 year after delivery
( Ji Hyun Keum ),( Joong Sub Choi ),( Jaeman Bae ),( Un Suk Jung ),( Won Moo Lee ),( Jeong Min Eom ),( A Ra Koh ) 대한산부인과학회 2016 대한산부인과학회 학술대회 Vol.102 No.-
The long-term risks of cesarean section include; (1) uterine rupture of the incision site before delivery, (2) complications with future pregnancies such as cesarean scar pregnancy and abnormal implantation of placenta, (3) malpositioned intrauterine devices and endometriosis of the site. We report a case of delayed rupture of cesarean section scar site occurred 1 year after delivery. A 38-year-old woman was referred to our hospital with cyclic lower abdominal pain. She had a cesarean section approximately 1 year earlier. The pain started since her menstruation had resumed after giving birth. In the diagnostic work-up, a pelvic MRI showed an about 7 cm sized well defined cystic lesion at the cesarean section scar site. We performed a laparoscopic surgery on October 14, 2015. Operative finding showed a 7 cm distended cystic lesion between the posterior bladder wall and anterior lower uterine body. We opened the lesion by a peritoneum incision and drained the dark brown colored cystic fluid. After we pushed the bladder wall away from the cyst, we resected the lesion completely from the cesarean section scar site. Then, we discovered perforation of lower uterine wall, connected to endometrial cavity. The perforation site was repaired using laparoscopic intracorporeal suturing, and we confirmed no leakage at the site. The patient recovered with no problems. The histopathology report showed atypical epitheloid trophoblastic lesion. We present this case along with a video clip.
Physicochemical Properties of Mung Bean Starch Paste, a Main Ingredient of Omija-eui
Keum-Il Jang,Hyun Jeong Han,Kwang Yeon Lee,In Young Bae,Ji Yeon Lee,Mi Kyung Kim,Hyeon Gyu Lee 한국식품과학회 2009 Food Science and Biotechnology Vol.18 No.4
As a principle ingredient in omija-eui, the physicochemical properties of mung bean starch (MBS) paste were investigated and compared to those of rice and corn starch. The amylose and the protein content of MBS were higher than those of rice or corn starch while the total sugar content and the swelling power of MBS were lower. In addition, the clarity of MBS paste was higher than either rice or corn starch paste. Regarding pasting properties, the peak viscosity and cool paste viscosity of MBS were higher than those of either rice or corn starch. During the freeze-thaw cycle, MBS exhibited higher degree of syneresis than corn and rice starch, which decreased with high starch concentration and heating temperature. The paste properties and freeze-thaw stability of MBS showed a potential for improving the quality of omija-eui.
( Ji Hyun Keum ),( Joong Sub Choi ),( Jaeman Bae ),( Won Moo Lee ),( Jung Min Eom ),( Hyo Jin Lee ),( Eunsaem Choi ) 대한산부인과학회 2018 대한산부인과학회 학술대회 Vol.104 No.-
Objective: This study aimed to compare the overall survival and disease free survival between laparoscopically-assisted staging surgery and laparotomic staging surgery for primary epithelial ovarian cancer. Methods: We reviewed clinical charts of women with epithelial ovarian cancer in tertiary Korean medical centers. We conducted the study using case-matched analysis to obtain equal cohorts of patients with respect to age, FIGO stage, histopathologic type, and tumor grade to assess surgical outcomes and survival. Results: Fifty-two patients (26 matched pairs) with epithelial ovarian cancer were selected to the study. There were no significant differences from two groups in terms of demographic and clinical characteristics. At a median follow-up of 69 months (range, 15-146 months), disease-free survival (P: 0.72) and overall survival (P: 0.53) were similar in both groups. Conclusion: Laparoscopically-assisted staging surgery did not show the differences in overall survival and disease free survival compared to laparotomic staging surgery. Laparoscopically-assisted staging surgery can be offered a treatment modality for selected women with advanced epithelial ovarian cancer.
( Ji Hyun Keum ),( Jaeman Bae ),( Joong Sub Choi ),( Won Moo Lee ),( Jeong Min Eom ),( Hyo Jin Lee ),( Yun Seo Choe ) 대한산부인과학회 2018 대한산부인과학회 학술대회 Vol.104 No.-
The patient, a 50-year-old woman (gravida 2, para 2), visited the local clinic for constipation. Image studies revealed a 10 cm, heterogenous, multi-septated mass in both ovaries. Initial CA 125 was 100.7 U/ml. A pap smear was performed, and the result was negative. During surgery, the tumor was noted to arise from both ovaries. Laparoscopic bilateral salpingo-oophorectomy was performed. Microscopic evaluation of the right ovary revealed ovarian choriocarcinoma, a borderline mucinous tumor, and metastatic adenocarcinoma. Left ovary evaluation revealed an ovarian borderline mucinous tumor and metastatic adenocarcinoma. After confirming the final histological examination, laparoscopic re-staging surgery was performed. Microscopic finding of the uterus was endocervical adenocarcinoma with direct extension to the endometrium and myometrium and a pelvic lymph node on the left side revealed metastatic adenocarcinoma. After surgery, we performed concurrent chemo-radiation therapy with weekly cisplatin (50 mg/m2) for cervical cancer. Abdominal CT was performed and there was no evidence of recurrence. However, -HCG increased from 18.6 to 65.24 (mIU/ml). Chemotherapy was decided and treatment with an EMA-CO regimen was started. At this time, a lesion was observed in the right upper lobe of the chest radiograph. Three cycles of EMA-CO chemotherapy were performed. -HCG after three cycles of chemotherapy was 93.64 (mIU/ml). On chest CT, the size of the nodule in the right upper lobe was increased to 2 cm. Therefore, We changed chemotherapy regimen into Paclitaxel andcarboplatin. AfCHter the second cycle of chemotherapy, the patient was admitted due to worsening of chest metastases with fever, sore throat, and leukopenia. Chest nodule was confirmed to chroicarcinoma through fine needle aspiration biopsy and serum level of -HCG was increased after changing the regimen with EP-EMA and topotecan and bevacizumab. She died after brain metastasis.
연구논문 : 과흥분성 조절 전략을 적용한 초등 과학 영재교육 프로그램이 초등과학 영재의 과제 집착력 및 창의적 인성에 미치는 영향
문지영 ( Ji Young Moon ),배진호 ( Jin Ho Bae ),소금현 ( Keum Hyun So ) 한국초등과학교육학회 2014 초등과학교육 Vol.33 No.3
The purpose of this study was to develop a science gifted education program as a strategy for modulating gifted children`s overexcitabilities and to examine the effect of such program on task commitment and creative personality. The results of this study were as follows. First, science gifted education program which modulated gifted children`s overexcitabilities showed significant effect on the improvement of task commitment. Looking at sub domains, significant results were obtained at self-regulation. Second, science gifted education program which modulated gifted children`s overexcitabilities showed significant effect on the improvement of creative personality. Looking at sub domains, significant results were obtained at the self-conviction and humors. Third, students who experienced the classes showed affirmative responses that the new teaching method was interesting and helpful. Looking at the above results, science gifted education program which modulated gifted children`s overexcitabilities can be considered as effective for improving task commitment and creative personality of elementary scientific gifted students.
김지은 ( Ji Eun Kim ),방소영 ( So Young Bang ),안상봉 ( Sang Bong Ahn ),임금남 ( Keum Nam Rim ),김현수 ( Hyun Soo Kim ),엄완식 ( Wan Sik Uhm ),김태환 ( Tae Hwan Kim ),전재범 ( Jae Bum Jun ),배상철 ( Sang Cheol Bae ),유대현 ( Dae H 대한류마티스학회 2007 대한류마티스학회지 Vol.14 No.4
Objective: Juvenile rheumatoid arthritis (JRA) is classified as polyarticular, oligoarticular, and systemic onset type by clinical symptoms presented during first six months. This study was performed to investigate the clinical features and course of systemic onset JRA. Methods: We performed a retrospective study for patients who were diagnosed as JRA between March 2000 and March 2006 according to the JRA criteria of the International League of Association for Rheumatology (ILAR). Results: Of the 216 JRA patients, 33 patients (11 male/ 22 female) were systemic onset type. Because of insufficient data, 6 patients were excluded. Chief complaints at the time of diagnosis were fever (81.5%) and arthralgia (77.7%). During the disease course, all patients manifested fever and arthritis, rash (59.2%) and splenomegaly (22.2%) also occurred. Most patients had symmetric (81.5%) arthritis, and involved more than five joints (59.3%) including knee and wrist. Anemia, leukocytosis, and thrombocytosis were common laboratory abnormalities. Almost all patients had elevated level of C-reactive protein and erythrocyte sediment rate. Some patients had positive results about immunologic marker such as rheumatoid factor (3.8%), antinuclear antibody (57.7%), and antiperinuclear factor (9.5%). Therapeutic regimens included glucocorticoids (88.9%), nonsteroidal anti-inflammatory drugs (81.5%), methotrexate (81.5%), and hydroxychloroquine (55.6%). Biologic agents were applied in 5 patients, and 3 showed improvement of disease activity. Combination therapy was introduced in 18.5% of patients, and 63% of patients still required medications. Conclusion: In Korea, systemic onset JRA patients had variable clinical manifestations and chronic course of disease, which often extended into adulthood.