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Jung, Jeeyoun,Jung, Youngae,Bang, Eun Jung,Cho, Sung-il,Jang, You-Jin,Kwak, Jung-Myun,Ryu, Do Hyun,Park, Sungsoo,Hwang, Geum-Sook Raven Press 2014 Annals of Surgical Oncology Vol.21 No.suppl4
<P>Mass screening for gastric cancer (GC), particularly using endoscopy, may not be the most practical approach as a result of its high cost, lack of acceptance, and poor availability. Thus, novel markers that can be used in cost-effective diagnosis and noninvasive screening for GC are needed.</P>
Metabolic profiling study of ketoprofen-induced toxicity
Jeeyoun Jung,황금숙 한국자기공명학회 2011 Journal of the Korean Magnetic Resonance Society Vol.15 No.1
1H nuclear magnetic resonance (NMR) spectroscopy of biological samples has been proven to be an effective and nondestructive approach to probe drug toxicity within an organism. In this study, ketoprofen toxicity was investigated using ^(1)H-NMR spectroscopy coupled with multivariate statistical analysis. Histopathologic test of ketoprofen-induced acute gastrointestinal damage in rats demonstrated a significant dose-dependent effect. Furthermore, principal component analysis (PCA) derived from ^(1)H-NMR spectra of urinary samples showed clear separation between the vehicle-treated control and ketoprofen-treated groups. Moreover, PCA derived from endogenous metabolite concentrations through targeted profiling revealed a dose-dependent metabolic shift between the vehicle-treated control, low-dose ketoprofen-treated (10 mg/kg body weight), and high-dose ketoprofen-treated (50 mg/kg) groups coinciding with their gastric damage scores after ketoprofen administration. The resultant metabolic profiles demonstrated that the ketoprofen-induced gastric damage exhibited energy metabolism perturbations that increased urinary levels of citrate, cis-aconitate, succinate, and phosphocreatine. In addition, ketoprofen administration induced an enhancement of xenobiotic activity in fatty oxidation, which caused increase levels of N-isovalerylglycine, adipate, phenylacetylglycine, dimethylamine, betaine, hippurate, 3-indoxylsulfate, N,N-dimethylglycine, trimethyl-N-oxide, and glycine. These findings demonstrate that ^(1)H-NMR–based urinary metabolic profiling can be used for noninvasive and rapid way to diagnose adverse drug effects and is suitable for explaining the possible biological pathways perturbed by nonsteroidal anti-inflammatory drug toxicity.
Metabolic Responses to <i>Orientia tsutsugamushi</i> Infection in a Mouse Model
Jung, Jeeyoun,Jung, Youngae,Gill, Byoungchul,Kim, Changhun,Hwang, Kyu-Jam,Ju, Young-Ran,Lee, Hye-Ja,Chu, Hyuk,Hwang, Geum-Sook Public Library of Science 2015 PLoS neglected tropical diseases Vol.9 No.1
<▼1><P>Tsutsugamushi disease is an infectious disease transmitted to humans through the bite of the <I>Orientia tsutsugamushi</I>-infected chigger mite; however, host-pathogen interactions and the precise mechanisms of damage in <I>O. tsutsugamushi</I> infections have not been fully elucidated. Here, we analyzed the global metabolic effects of <I>O. tsutsugamushi</I> infection on the host using <SUP>1</SUP>H-NMR and UPLC-Q-TOF mass spectroscopy coupled with multivariate statistical analysis. In addition, the effect of <I>O. tsutsugamushi</I> infection on metabolite concentrations over time was analyzed by two-way ANOVAs. Orthogonal partial least squares-discriminant analysis (OPLS-DA) showed distinct metabolic patterns between control and <I>O. tsutsugamushi</I>-infected mice in liver, spleen, and serum samples. <I>O. tsutsugamushi</I> infection caused decreased energy production and deficiencies in both remethylation sources and glutathione. In addition, <I>O. tsutsugamushi</I> infection accelerated uncommon energy production pathways (i.e., excess fatty acid and protein oxidation) in host body. Infection resulted in an enlarged spleen with distinct phospholipid and amino acid characteristics. This study suggests that metabolite profiling of multiple organ tissues and serum could provide insight into global metabolic changes and mechanisms of pathology in <I>O. tsutsugamushi</I>-infected hosts.</P></▼1><▼2><P><B>Author Summary</B></P><P>Scrub typhus is an acute febrile illness caused by attacks of <I>Orientia tsutsugamushi</I>-carrying mites, and is the most prevalent febrile illness in the Asia-Pacific region. If not properly treated with antibiotics, patients often develop severe vasculitis that affects multiple organs, and the mortality rate can reach 30%. To explore the pathogenic mechanisms underlying the host-pathogen interaction, we characterized metabolic changes in various organs and the serum of <I>O. tsutsugamushi</I>-infected hosts. After <I>O. tsutsugamushi</I> infection, the host experienced decreased energy production, as well as a severe deficiency in re-methylation sources and glutathione, which impaired purine synthesis, DNA and protein methylation. In addition, abnormal pathways for phosphatidylcholine (PC) biosynthesis and phosphoethanolamine methylation were utilized in the enlarged spleen of <I>O. tsutsugamushi</I>-infected hosts. These results suggested that metabolic profiling could provide insight into global metabolic changes in <I>O. tsutsugamushi</I>-infected hosts, and increase our understanding of the pathogenic mechanisms of <I>O. tsutsugamushi</I>, as well as providing novel therapeutic targets for scrub typhus.</P></▼2>
Changes in one-carbon metabolism after duodenal-jejunal bypass surgery
Jung, Jeeyoun,Ha, Tae Kyung,Lee, Jueun,Lho, Yunmee,Nam, Miso,Lee, Doohae,le Roux, Carel W.,Ryu, Do Hyun,Ha, Eunyoung,Hwang, Geum-Sook American Physiological Society 2016 AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND M Vol.310 No.8
<P>Bariatric surgery alleviates obesity and ameliorates glucose tolerance. Using metabolomic and proteomic profiles, we evaluated metabolic changes in serum and liver tissue after duodenal-jejunal bypass (DJB) surgery in rats fed a normal chow diet. We found that the levels of vitamin B-12 in the sera of DJB rates were decreased. In the liver of DJB rats, betaine-homocysteine S-methyltransferase levels were decreased, whereas serine, cystathionine, cysteine, glutathione, cystathionine beta-synthase, glutathione S-transferase, and aldehyde dehydrogenase levels were increased. These results suggested that DJB surgery enhanced trans-sulfuration and its consecutive reactions such as detoxification and the scavenging activities of reactive oxygen species. In addition, DJB rats showed higher levels of purine metabolites such as ATP, ADP, AMP, and inosine monophosphate. Decreased guanine deaminase, as well as lower levels of hypoxanthine, indicated that DJB surgery limited the purine degradation process. In particular, the AMP/ATP ratio and phosphorylation of AMP-activated protein kinase increased after DJB surgery, which led to enhanced energy production and increased catabolic pathway activity, such as fatty acid oxidation and glucose transport. This study shows that bariatric surgery altered trans-sulfuration and purine metabolism in the liver. Characterization of these mechanisms increases our understanding of the benefits of bariatric surgery.</P>
Perspectives on the Market Globalization of Korean Herbal Manufacturers: A Company-Based Survey
Kim, Dongsu,Ahn, Miyoung,Jung, Jeeyoun,Kwon, Soohyun,Park, Eun-Ji,Koo, Ki Hoon,Woo, Jong-Min Hindawi Publishing Corporation 2015 Evidence-based Complementary and Alternative Medic Vol.2015 No.-
<P>The growth of herbal markets has increased substantially in South Korea, but the worldwide market share remains small despite significant governmental efforts. This study aimed to characterize manufacturing employment and identify employees' general perceptions of market expansion. A survey study covering 567 companies was conducted using face-to-face interviews in 2012. Data were analyzed using comparisons among three manufacturing groups (i.e., the herbal dietary supplement manufacturing group, the herbal medicine manufacturing group, and the personal care product manufacturing group) or among the manufacturers themselves. We found that the majority of the manufacturing employee respondents were regular permanent and production workers. The domestic distributors were primarily chain stores/direct outlets or retailers/wholesalers, and the dominant product was red ginseng (<I>hongsam</I>). Although the responding companies exhibited a variety of perspectives, “advertisement/public relations” was cited as the most important factor in the development of the herbal industry. In contrast, “low manpower/seeking business partners” were the most crucial limiting and challenging factors for market globalization. Our results can be used to design a proper national plan by reducing the gaps in perspective between herbal product producers and policy makers.</P>
Korean Studies on Blood Stasis: An Overview
Park, Bongki,You, Sooseong,Jung, Jeeyoun,Lee, Ju Ah,Yun, Kyung-Jin,Lee, Myeong Soo Hindawi Publishing Corporation 2015 Evidence-based Complementary and Alternative Medic Vol.2015 No.-
<P>Blood stasis is one of the important pathological concepts in Korean medicine. We analyzed the Korean studies concerning blood stasis. We searched for articles in eight electronic databases from their inception to September, 2014. We included reviews, clinical studies, and preclinical studies that had studied blood stasis and excluded articles in which blood stasis was not mentioned or in which the original authors had not explained blood stasis. Of 211 total included studies, 19 were reviews, 52 were clinical studies, and 140 were preclinical articles. “Stagnant blood within the body” was the most frequently mentioned phrase of the traditional concept of blood stasis. Traumatic injury was the most frequently studied disease/condition in the clinical studies. In the preclinical studies, coagulopathy was studied most frequently, followed by hyperviscosity, hyperlipidemia, inflammation, neoplasm, ischemic brain injury, and atherosclerosis. Hyeolbuchukeo-tang and Angelicae Gigantis Radix were the most frequent formula and single herb, respectively, used in the blood stasis researches. The results showed that blood stasis was mainly recognized as disorder of circulation and many studies showed the effectiveness of activating blood circulating herbs for diseases and pathologies such as traumatic injury or coagulopathy. Further studies are needed in the pathologic mechanisms and various diseases of blood stasis.</P>