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RISS 인기검색어
- 검색키워드
- 저자 : Jeevithan, Elango (검색결과 3 건)
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Saravanakumar, Kandasamy,Jeevithan, Elango,Chelliah, Ramachandran,Kathiresan, Kandasamy,Wen-Hui, Wu,Oh, Deog-Hwan,Wang, Myeong-Hyeon Elsevier 2018 INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES Vol.119 No.-
<P><B>Abstract</B></P> <P>Chitosan (CS), a novel biomaterial is widely used as a drug nano-carrier for cancer treatments. Towards this aim, anticancer and antibacterial activities of CS-nanoparticles-linked zinc (Zn-CSNPs) were evaluated. The particle size of CSNPs was lowered (113.09 nm) compared to Zn-CSNPs (160.7 nm). Both nanoparticles (CSNPs and Zn-CSNPs) were spherical in shape, polydispersive and homogenous. Fourier transforms infrared spectrophotometer (FTIR) and energy dispersive X-ray spectroscopy (EDX) analysis confirmed the different molecular arrangement of NPs and the presence of Zn in Zn-CSNPs and CS in both NPs, respectively. Zn-CSNPs had higher inhibitory activity against tested pathogens with a minimal inhibitory concentration (MIC) of 9.25–13.5 μg·mL<SUP>−1</SUP> and showed the complete inhibition of <I>Staphylococcus aureus</I> and <I>Escherichia coli</I>. Zn-CSNPs have triggered the apoptosis through activation of first apoptosis signal receptor/cluster of differentiation 95 (Fas/CD95), and apoptotic-regulatory genes and caused 65–70% of cellular damage in human acute T-lymphocyte leukemia (6T-CEM) cells. Overall, internalizing properties of Zn from CSNPs is a promising therapeutic approach to treat Zn-deficiency related diseases particularly human acute leukemia (HAL).</P> <P><B>Highlights</B></P> <P> <UL> <LI> Zinc-chitosan nanoparticles (Zn-CSNPs) spherical shape with good polydispersion </LI> <LI> Zn-CSNPs inhibit the growth of clinical pathogens especially <I>S</I>. <I>aureus</I> and <I>E</I>.<I>coli</I>. </LI> <LI> Zn-CSNPs triggered apoptosis via Fas and caspase-cascade pathway in 6T-CEM </LI> <LI> These NPs can be used to treat bacterial infections, zinc deficiency related diseases. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
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Saravanakumar, Kandasamy,Chelliah, Ramachandran,MubarakAli, Davoodbasha,Jeevithan, Elango,Oh, Deog-Hwan,Kathiresan, Kandasamy,Wang, Myeong-Hyeon Elsevier 2018 International journal of biological macromolecules Vol.118 No.2
<P><B>Abstract</B></P> <P>This paper reports the synthesis of chitosan nanoparticles (T-CSNPs) using the fungal enzyme of <I>Trichoderma harzianum</I> and its biocompatibility, antioxidant and bactericidal properties. The T-CSNPs synthesis was confirmed by absorbance at 280 nm using UV–Vis spectrophotometer. T-CSNPs were of spherical shape, as evident by field emission transmission electron microscopic (FETEM) analysis, and the average size of T-CSNPs was 90.8 nm, as calculated using particle size analyzer (PSA). The functional groups showed modifications of chitosan in T-CSNPs as evident by fourier-transform infrared spectroscopic (FTIR) analysis. T-CSNPs were found soluble at the wide range of pH, showing 100% solubility at pH 1–3 and 72% at pH 10. The T-CSNPs exhibited antioxidant property in a dose-dependent manner with pronounced activity at 100 mg·mL<SUP>−1</SUP>. The T-CSNPs also showed bactericidal activity against <I>Staphylococcus aureus</I> and <I>Salmonella enterica</I> Typhimurium by causing detrimental effects on bacterial cells. The T-CSNPs (50 μg·mL<SUP>−1</SUP>) did not display any cytotoxic effect on murine fibroblast NIH-3T3 cells, as evident by cell viability and acridine orange/ethidium bromide staining assays, which confirmed biocompatibility of the nanoparticles. This work suggested further investigations on the utilization of the mycosynthesized nanochitosan in biomedical applications.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Synthesized the bioactive chitosan nanoparticles (T-CSNPs) using fungal extract of <I>Trichoderma</I> sp. </LI> <LI> Determined the molecular weight of enzyme in the fungal extract </LI> <LI> Enhanced the antioxidant and the bactericidal activities of T-CSNPs </LI> <LI> Assessed the biocompatibility of the T-CSNPs through cytotoxicity assay against NIH-3T3 cells </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
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Saravanakumar, Kandasamy,Mandava, Suresh,Chellia, Ramachandran,Jeevithan, Elango,Babu Yelamanchi, Ravi Shankar,Mandava, Deepthi,Wen-Hui, Wu,Lee, Jongkook,Oh, Deog-Hwan,Kathiresan, Kandasamy,Wang, Myeo Elsevier 2019 Microbial pathogenesis Vol.126 No.-
<P><B>Abstract</B></P> <P>The present study aimed to purify and identify the metabolites from <I>T. atroviride</I> using high-performance liquid chromatography (HPLC) and <SUP>1</SUP>H and <SUP>13</SUP>C nuclear magnetic resonance spectrometer (NMR) followed by analyzing their toxicological, antibacterial and anticancer properties. This work identified two metabolites - TM1 and TM2. TM1 was in two forms: (i) 1, 3-dione-5, 5-dimethylcyclohexane; and, (ii) 2-enone-3hydroxy −5,5-dimethylcylohex, while TM2 was 4H-1,3-dioxin-4-one-2,3,6-trimethyl. These metabolites did not exhibit any irritant or allergic reaction as revealed by HET- CAM test. TM2 significantly inhibited the growth of <I>H. pylori</I> and Shigella toxin producing <I>Escherichia coli</I> (STEC) as evident by <I>in vitro</I> and microscopic observations of bacterial cell death. TM2 also induced the cell death and cytotoxicity, as revealed by cell viability test and western blot analysis. According to microscopic, flow cytometer and western blot analysis, TM2 treated cells displayed higher ROS, cell death, and apoptosis-related protein expression than TM1 and control. This study concluded that TM2 derived from <I>T. atroviride</I> was a potential therapeutic agent for anti-prostate cancer and antibiotic agent against MDR- <I>H. pylori</I> and STEC and it is also recommended to carry out further <I>in vivo</I> animal model experiments with improved stability of the metabolites for future pharmaceutical trails.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Fungal metabolites against <I>H. pylori</I> and Shigella toxin producing <I>Escherichia coli</I> (STEC). </LI> <LI> <I>Trichoderma</I> derived metabolites exhibited the antibacterial, and anticancer activity. </LI> <LI> TM2 reported as the potential therapeutic agent against - <I>H. pylori</I>, STEC, and anti-prostate cancer. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
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