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EEG, fMRI, EAV 및 SQUID장치(裝置)를 이용(利用)한 기공현상(氣功現狀) 측정(測定)
장경선 ( Kyeong Seon Jang ),정찬원 ( Chan Won Jeong ),최찬헌 ( Chan Hun Choi ),윤유식 ( Wu Sik Yoon ),소철호 ( Cheal Ho So ),나창수 ( Chang Su Na ) 대한경락경혈학회 2004 Korean Journal of Acupuncture Vol.21 No.2
Objectives: Human physiological changes in the state of qigong has been measured using EEG(Electroencephalography), functional MRI(functional Magnetic Resonance Image), EAV(Electro-Acupuncture according to Voll) and SQUID(Superconducting Quantum Interference Device) measurements. Methods & Results: EEGs were measured to study the differences between Qigong masters and Qi receiver on the changes of EEG. During Qigong, an alpha waves were increased. The power spectra indicate that the peak frequency of alpha waves increased during Qigong. Qi receiver`s EEG signals seemed to affected by the state of himself. Brain activation did not observed when qigong master concentrates the Qi at Laogong(P8). But a localization of fMRI signal in the sensory cortex was observed by electric acupuncture stimulation at Laogong(P8). Five phase deviation of EAV were clearly changed in the both cases of Qigong master and Qi receiver. When a Qigong master concentrates the Qi at Yintang, Laogong(P8), Qihai(CV6) meridian points during Qigong state, the change of magnetic field around acupoints Yintang, Laogong points has been measured using 40-Channel DROS-SQUID apparatus. After smoothing process of the continuously measured magnetic signal around acupoints for a few minutes, we could observe that a series of peaks, magnitude of -1.0~2.5pT appeared. But there was no significant difference in changes of magnetic signal around acupoints. Physical signals of magnetocardiogram has been measured by using 2-Channel DROS SQUID(Magnetocardiogram). Physical signals of magnetocardiogram were clealy changed at the ST segments after S-wave when qigong master concentrates the Qi.
CDRgator: An Integrative Navigator of Cancer Drug Resistance Gene Signatures
Jang, Su-Kyeong,Yoon, Byung-Ha,Kang, Seung Min,Yoon, Yeo-Gha,Kim, Seon-Young,Kim, Wankyu Korean Society for Molecular and Cellular Biology 2019 Molecules and cells Vol.42 No.3
Understanding the mechanisms of cancer drug resistance is a critical challenge in cancer therapy. For many cancer drugs, various resistance mechanisms have been identified such as target alteration, alternative signaling pathways, epithelial-mesenchymal transition, and epigenetic modulation. Resistance may arise via multiple mechanisms even for a single drug, making it necessary to investigate multiple independent models for comprehensive understanding and therapeutic application. In particular, we hypothesize that different resistance processes result in distinct gene expression changes. Here, we present a web-based database, CDRgator (Cancer Drug Resistance navigator) for comparative analysis of gene expression signatures of cancer drug resistance. Resistance signatures were extracted from two different types of datasets. First, resistance signatures were extracted from transcriptomic profiles of cancer cells or patient samples and their resistance-induced counterparts for >30 cancer drugs. Second, drug resistance group signatures were also extracted from two large-scale drug sensitivity datasets representing ~1,000 cancer cell lines. All the datasets are available for download, and are conveniently accessible based on drug class and cancer type, along with analytic features such as clustering analysis, multidimensional scaling, and pathway analysis. CDRgator allows meta-analysis of independent resistance models for more comprehensive understanding of drug-resistance mechanisms that is difficult to accomplish with individual datasets alone (database URL: http://cdrgator.ewha.ac.kr).
P003 : Blood type B-specific difference in skin phenotypes of Korean women
( Jang Hee Oh ),( Inn Gyung Oh ),( Chi Hyun Park ),( Min Kyeong Shin ),( Serah Lee ),( Dong Hun Lee ),( Mira Choi ),( Seon Pil Jin ),( Soyun Cho ),( Jin Ho Chung ) 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.2
Background: ABO blood group antigen expression was found on many tissues including the granular of the epidermis. Objectives: To investigate the blood type-specific difference in normal skin phenotypes in Korean women. Methods: Skin hydration, transepidermal water loss (TEWL), wrinkle depth, elasticity, or skin erythema/melanin index, were analyzed according to the blood type. Results: The skin hydration at buttock skin showed significantly lower in B blood type individuals than non-blood type B individuals of same young age range (20~49 yr, mean age; 34.0±9.3 yr, n=40), but TEWL of them showed no difference. However, the skin hydration and TEWL in old age range (54~84 yr, mean age; 70.4±6.2 yr, n=126) showed no B blood type-specific difference in inner-arm skin. The eye wrinkle depth in old B blood type individuals also was observed to be significantly deeper than non-B blood type individuals of same old age range. Deeper eye wrinkle was also observed in O blood type than A or AB blood type, but seemed less than B blood type. However, their skin elasticity showed no difference. The melanin index in old B blood type individuals also showed less measurement, which means bright skin color, than non-B blood type individuals, while the erythema index did not. Conclusion: In conclusion, we found that B blood type individuals probably has most distinct skin phenotypes, including less hydration, deeper eye wrinkle, and bright skin color in Korean women.
Kyeong Mi Kim,Nam Seon Kang,Hyeong Seok Jang,Joon Sang Park,Byung Hee Jeon,Ji Won Hong 한국해양바이오학회 2017 한국해양바이오학회지 Vol.9 No.2
A unicellular green alga was axenically isolated from the Port of Jeongja, Ulsan, Korea. Morphological, molecular, and biochemical analyses revealed that the isolate belonged to Heterochlorella luteoviridis. This is the first report of this species in Korea. The microalgal strain was named as H. luteoviridis MM0014 and its growth, lipid composition, and biomass properties were investigated. The strain thrived over a wide range of temperatures (5–30°C) and withstood up to 0.5 M NaCl. The results of gas chromatography/mass spectrometry analysis showed that the isolate was rich in nutritionally important polyunsaturated fatty acids. Its major fatty acids were linoleic acid (35.6%) and α-linolenic acid (16.2%). Thus, this indigenous marine microalga is a potential alternative source of ω3 and ω6 polyunsaturated fatty acids, which are currently obtained from fish and plant oils. Ultimate analysis indicated that the gross calorific value was 19.7 MJ kg-1. In addition, the biomass may serve as an excellent animal feed because of its high protein content (51.5%). Therefore, H. luteoviridis MM0014 shows promise for applications in the production of microalgae-based biochemicals and biomass feedstock.