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RISS 인기검색어
- 검색키워드
- 저자 : Hyein Yeo (검색결과 3 건)
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Characteristics of Epilepsy in Children with Cerebral Palsy: A Single Tertiary Center Study
Hyein Yeo,한지윤,Jee Min Kim 대한소아신경학회 2023 대한소아신경학회지 Vol.31 No.4
Purpose: The aim of this study was to describe the characteristics of epilepsy in cerebral palsy (CP) patients and identify risk factors for epilepsy and drug-resistant epilepsy. Methods: CP patients aged 18 years old or younger who visited the pediatric neurology department and/or rehabilitation department of a tertiary care hospital between January 2016 and December 2022 with a minimum follow-up period of 2 years were included. Demographic and clinical data, seizure characteristics, brain imaging, electroencephalography, and genetic evaluation results were reviewed retrospectively. Results: Among 268 patients included in this study, 36.9% had epilepsy and 10.8% had drug-resistant epilepsy. Asphyxia (29.3%), hemorrhage, infarction, and brain infection (25.3%) were associated with epilepsy. Epileptic CP patients were more likely to experience neonatal seizures (18.2% vs. 4.1%, P<0.001) and febrile seizures (12.1% vs. 7.1%, P=0.02) than non-epilepsy CP patients. The most common cerebral subtype in patients with epilepsy was spastic quadriplegia (59.6%). Epilepsy patients were more severely impaired in gross motor function, with worse intellectual disability. Patients with macrocephaly or cerebral malformation were more likely to have drug resistance. Valproate (51.7% and 25.7%) and levetiracetam (41.4% and 25.7%) were the two most commonly used antiseizure medications, both in monotherapy and polytherapy. Conclusion: A history of asphyxia, febrile seizure, neonatal seizure, spastic quadriplegia, more severely impaired gross motor function, and intellectual disability were found to be risk factors for epilepsy. Further research with prospective data collection to develop a model for predicting seizures or epilepsy in CP patients is needed.
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Kwon Yeonju,Lee Hyein,Park Hyemin,Lee Boyoung,Kwon Tae-Uk,Kwon Yeo-Jung,Chun Young-Jin 한국독성학회 2023 Toxicological Research Vol.39 No.4
The Hippo pathway is a signaling pathway that controls organ size in animals by regulating cell proliferation and apoptosis. Yes-associated protein 1 (YAP1), an oncogene associated with the development and progression of breast cancer, is downregulated by the Hippo pathway and is associated with the development and progression of breast cancer. Yippee-like 3 (YPEL3) is a target gene of the tumor suppressor protein p53, and its activation has been shown to inhibit cell growth, induce cellular senescence, and suppress tumor cell metastasis. In this study, we found that YAP1 inhibits the expression of YPEL3 expression in breast cancer cells. Furthermore, a decrease in lamin B1, a marker protein of cellular senescence, coupled with the activation of senescence-associated β-galactosidase indicated that upregulating YPEL3 levels through YAP1 downregulation can induce cellular senescence. Additionally, elevated YPEL3 levels resulted in higher levels of oxygen consumption rate in mitochondria, thus promoting apoptosis. This suggests that YPEL3 plays a crucial role in regulating oxidative stress and cell apoptosis in breast cancer cells. Therefore, the interaction between YAP1 and YPEL3 represents a novel mechanism of cellular senescence mediated by the Hippo signaling pathway. Collectively, our findings suggest that the Hippo signaling pathway plays an important role in regulating cellular senescence, which could have implications for the development of new therapeutic strategies for diseases such as cancer.
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Lim Boram,Kim Young‐Hun,Kim Hyein,Park Myeongnam,Yeo Huisu,Koo Sangho 대한화학회 2022 Bulletin of the Korean Chemical Society Vol.43 No.8
2,7-Diphenalkyl-4-octenedials 3 were prepared for the syntheses of 13,130- diphenalkyl β-carotenes 1b–1d, which serve as the intramolecular models for the π-stacking interactions of chlorophylls and carotenoids. The optimal tether length of the 13-phenalkyl substituents in carotenes 1b–1d for the maximum π–π interactions with the polyene chain was decided to be a three-methylene unit based on the most up-field chemical shifts of the nearby protons of H11 and H15 by the magnetic anisotropic effect of benzene rings, which would provide a valuable information in the assembly of a single molecular light-harvesting/ energy-transferring unit for artificial photosynthetic system.
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