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세계지리 수업에서 여행기를 활용한 정의적 영역의 보완
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Biomechanics and functional preconditions for terrestrial lifestyle in basal tetrapods^ with special consideration of Tiktaalik roseae
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모심과 살림
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Priority substances in sediments of the "Carska Bara" special nature reserve^ a natural scientific research area on the UNESCO list
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중환자실 입원환자의 구강간호 프로토콜 개발
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현장검사기기 i-STAT의 평가
- 검색키워드
- 저자 : Huanhuan Gao (검색결과 5 건)
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DHEM: a deep heat energy method for steady-state heat conduction problems
Huanhuan Gao,Wenjie Zuo,Zengming Feng,Jinxing Yang,Tingting Li,Ping Hu 대한기계학회 2022 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.36 No.11
Based on the deep energy method recently brought forward to handle linearelastic or hyper-elastic finite deformation problems in solid mechanics, in this paper, we propose a deep heat energy method (DHEM) which is specially tailored to deal with structural steady-state heat conduction problems with the help of deep learning techniques. In our work, the deep neural networks are utilized to construct the admissible temperature fields; secondly, the potential energy functional in the heat conduction process which works as the loss function of the deep neural networks is calculated by numerical integration techniques; finally, the parameters of the network including weights and bias, are optimized by the quasi-Newton method to yield the minimal of the potential energy functional which indicates the heat conduction has entered a steady state. Numerical examples with a diversity of materials, including the isotropic and homogeneous material, the orthotropic material, the non-homogeneous materials and temperature dependent materials, are carried out to illustrate the validity and capacity of DHEM in both linear uncoupled and thermal-material coupling heat conduction problems.
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Ethanol Induces Autophagy Regulated by Mitochondrial ROS in Saccharomyces cerevisiae
( Hongjuan Jing ),( Huanhuan Liu ),( Lu Zhang ),( Jie Gao ),( Haoran Song ),( Xiaorong Tan ) 한국미생물 · 생명공학회 2018 Journal of microbiology and biotechnology Vol.28 No.12
Ethanol accumulation inhibited the growth of Saccharomyces cerevisiae during wine fermentation. Autophagy and the release of reactive oxygen species (ROS) were also induced under ethanol stress. However, the relation between autophagy and ethanol stress was still unclear. In this study, expression of the autophagy genes ATG1 and ATG8 and the production of ROS under ethanol treatment in yeast were measured. The results showed that ethanol stress very significantly induced expression of the ATG1 and ATG8 genes and the production of hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) and superoxide anion (O<sub>2</sub> <sup>·-</sup>). Moreover, the atg1 and atg8 mutants aggregated more H<sub>2</sub>O<sub>2</sub> and O<sub>2</sub> <sup>·-</sup> than the wild-type yeast. In addition, inhibitors of the ROS scavenging enzyme induced expression of the ATG1 and ATG8 genes by increasing the levels of H<sub>2</sub>O<sub>2</sub> and O<sub>2</sub> <sup>·-</sup>. In contrast, glutathione (GSH) and N-acetylcystine (NAC) decreased ATG1 and ATG8 expression by reducing H<sub>2</sub>O<sub>2</sub> and O<sub>2</sub> <sup>·-</sup> production. Rapamycin and 3-methyladenine also caused an obvious change in autophagy levels and simultaneously altered the release of H<sub>2</sub>O<sub>2</sub> and O<sub>2</sub> <sup>·-</sup>. Finally, inhibitors of the mitochondrial electron transport chain (mtETC) increased the production of H<sub>2</sub>O<sub>2</sub> and O<sub>2</sub> <sup>·-</sup> and also promoted expression levels of the ATG1 and ATG8 genes. In conclusion, ethanol stress induced autophagy which was regulated by H<sub>2</sub>O<sub>2</sub> and O<sub>2</sub> <sup>·-</sup> derived from mtETC, and in turn, the autophagy contributed to the elimination H<sub>2</sub>O<sub>2</sub> and O<sub>2</sub> <sup>·-</sup>.
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Multibody dynamics analysis of a silent chain drive timing system
Jinxing Yang,Zengming Feng,Huanhuan Gao,Tianrui Wang,Kai Xu 대한기계학회 2023 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.37 No.4
Multibody dynamics analysis of a silent chain drive timing system can quickly detect system defects in the product design stage and shorten the development cycle. At present, most of the research on chain drives focuses on roller chains. A 3D silent chain drive timing system model considering the fluctuation of crankshaft sprocket speed and camshaft sprocket torque was established in this paper based on recursive algorithm and Hertz contact theory. The accuracy of the model was verified by comparing the experimental and simulation results of the chain tension. The simulation results show that the chain tension fluctuation with time is obviously affected by the camshaft torque fluctuation, and the maximum chain tension ranges from 233 N to 1202 N, which is less than the safe rotation fatigue limit 1600 N. When the crankshaft sprocket speed is 6000 r/min, the maximum contact force between the chain and crankshaft sprocket and slack guide is 751 N and 588 N, respectively. The maximum chain fluctuation caused by meshing impact between chain and sprocket and polygon effect is 0.52 mm and 0.48 mm, respectively. The system transmission error ranges from 0.14° to 0.38°, which is less than 1° of the maximum allowable transmission error.
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Degradation Characteristics and Metabolic Pathway of 17β-estradiol (E2) by Rhodococcus sp. DS201
Qingmiao Yu,Ping Wang,Dongbo Liu,Ruixia Gao,Huanhuan Shao,Hongyan Zhao,Zhe Ma,Dan Wang,Hongliang Huo 한국생물공학회 2016 Biotechnology and Bioprocess Engineering Vol.21 No.6
In this study an E2-degrading bacterium was isolated from the activated sludge of a municipal treatment plant that treats the waste from a contraceptive medicineprocessing factory in Beijing, China. Using the observed morphological and physiological features of the bacterium and 16S rRNA sequence analysis, this bacterial strain was identified as Rhodococcus sp. DS201. Using single-factor experiments and orthogonal tests, it was demonstrated that, when strain DS210 bacteria were inoculated into MM medium at an initial concentration of 1 mg/L with an initial pH of 7 and an inoculum amount of 1%, complete degradation of E2 by this strain was achieved within 3 days at 30oC. After strain DS201 had degraded the E2, several E2 metabolites were detected in the culture extracts using high-performance liquid chromatography (HPLC); they were then further identified using HPLC with tandem mass spectrometry (LC-MS/MS). Mass spectrum analysis of the E2 degradation identified the following products: pent- 4-enoic acid; 2-ethyl-3-hydroxy-6-methylcyclohexane-1- carboxylic acid; 3-(7a-methyl-1,5-dioxooctahydro-1H-inden- 4-yl) propanoic acid; and 5-hydroxy-4-(3-hydroxypropyl)- 7a-methyloctahydro-1H-inden-1-one. These products have not previously been reported as parts of a mechanism for microbial E2 degradation and were suspected to be new metabolite products. Therefore, the E2 degradation pathway by strain DS201 is proposed herein.
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Hardware Implementation of Two-level Scheduling Algorithm in μC/OS-II
Guangwu Zhang,Yan Li,Yidong Chen,Huaiguo Dong,Huanhuan Chi,Min Shi,Junfeng Gao 보안공학연구지원센터 2016 International Journal of Smart Home Vol.10 No.4
Aiming at the problem that μC/OS-II does not support round-robin scheduling of the same priority task, a two-level hybrid task scheduling strategy was proposed. In the first level, by putting the task priority as criterion for task scheduling, a preemptive scheduling of different priority task was implemented. And in the second level, adopting time slice circulars scheduling strategy, round-robin scheduling of same priority task was implemented. The waiting list of tasks was designed by on-chip registers of FPGA and the ready list of tasks was designed by RAM of FPGA, and to implement time slice circulars scheduling, hardware circuit for finding successor of task was designed. The system adopted VHDL, and simulated by the software ISE10.1. The simulation results show that the hardware implementation of the system is well-worked.
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