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- 저자 : Hsiao-Yun Lu (검색결과 1 건)
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Hsiao-Yun Lu,Yi-Jou Tai,Yu-Li Chen,Ying-Cheng Chiang,Heng-Cheng Hsu,Wen-Fang Cheng 대한부인종양학회 2021 Journal of Gynecologic Oncology Vol.32 No.2
Objective: Cytoreductive surgery followed by adjuvant chemotherapy is a standard frontlinetreatment for epithelial ovarian cancer (EOC). We aimed to develop an ovarian cancer riskscore (OVRS) based on the expression of 10 ovarian-cancer-related genes to predict thechemoresistance, and outcomes of EOC patients. Methods: We designed a case-control study with total 149 EOC women including 75chemosensitives and 74 chemoresistants. Gene expression was measured using thequantitative real-time polymerase chain reaction. We tested for correlation between theOVRS and chemosensitivity or chemoresistance, disease-free survival (DFS), and overallsurvival (OS), and validated the OVRS by analyzing patients from the TCGA database. Results: The chemosensitive group had lower OVRS than the chemoresistant group (5 vs. 15, p≤0.001, Mann-Whitney U test). Patients with disease relapse (13 vs. 5, p<0.001, Mann Whitney U test) or disease-related death (13.5 vs. 6, p<0.001) had higher OVRS than thosewithout. OVRS ≥10 (hazard ratio=3.29; 95% confidence interval=1.94–5.58; p<0.001) was theonly predictor for chemoresistance in multivariate analysis. The median DFS (5 months vs. 24 months) and OS (39 months vs. >60 months) of patients with OVRS ≥10 were significantlyshorter than those of patients with OVRS <9). The high OVRS group also had significantlyshorter median OS than the low OVRS group in 255 patients in the TCGA database (39 vs. 49months, p=0.046). Conclusions: Specific genes panel can be clinically applied in predicting the chemoresistanceand outcome, and decision-making of epithelial ovarian cancer.
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