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음향방출기술을 이용한 원자력발전소 제어밸브 유체누설 상시감시에 관한 연구
이상국(Sang-Guk Lee),박종혁(Jong-Huck Park),이선기(Sun-Ki Lee),유근배(Keun-Bae Yoo),홍승열(Sung-Yull Hong) 대한기계학회 2006 대한기계학회 춘추학술대회 Vol.2006 No.6
The purpose of this study is to verify availability of the acoustic emission in-situ monitoring method to the internal leak and operating conditions of the major valves at nuclear power plants. In this study, acoustic emission tests are performed when the pressurized temperature water and steam flowed through glove valve for high pressure turbine condensing water dump and main steam condensing water control on the normal size of 1-1/2, 2-1/2 and 2 . The valve internal leak monitoring system for practical field was designed. The acoustic emission method was applied to the valves at the site, and the background noise was measured for the abnormal plant condition. To improve the reliability, a judgment of leak on the system was used various factors which are AE parameters, trend analysis, frequency analysis, voltage analysis and amplitude analysis of acoustic signal emitted from the valve operating condition internal leak.
이상국(Sang-Guk Lee),박종혁(Jong-Huck Park),이선기(Sun-Ki Lee),유근배(Keun-Bae Yoo),홍승열(Sung-Yull Hong) 대한기계학회 2006 대한기계학회 춘추학술대회 Vol.2006 No.11
To verify the system performance of portable AE leak diagnosis system which can measure with moving conditions, AE activities such as RMS voltage level, AE signal trend, leak rate degree according to AE database, FFT spectrum were measured during operation on total 11 valves of the secondary system in nuclear power plant. AE activities were recorded and analyzed from various operating conditions including different temperature, type of valve, pressure difference, valve size and fluid. The results of this field study are utilized to select the type of sensors, the frequency band for filtering and thereby to improve the signal-to-noise ratio for diagnosis for diagnosis or monitoring of valves in operation. As the final result of application study above, portable type leak diagnosis system by AE was developed. The outcome of the study can be definitely applied as a means of the diagnosis or monitoring system for energy saving and prevention of accident for power plant valve.
On-Yu Hong,Sang Yull Kang,Eun-Mi Noh,Hong-Nu Yu,Hye-Yeon Jang,Seong-Hun Kim,Jingyu Hong,Eun Yong Chung,Jong-Suk Kim 생화학분자생물학회 2022 BMB Reports Vol.55 No.2
Aurora kinase is a family of serine/threonine kinases intimatelyassociated with mitotic progression and the development ofhuman cancers. Studies have shown that aurora kinases areimportant for the protein kinase C (PKC)-induced invasion ofcolon cancer cells. Recent studies have shown that aurora kinaseA promotes distant metastasis by inducing epithelial-to-mesenchymaltransition (EMT) in colon cancer cells. However, the roleof aurora kinase A in colon cancer metastasis remains unclear. In this study, we investigated the effects of aurora kinase A onPKC-induced cell invasion, migration, and EMT in human SW480colon cancer cells. Treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA) changed the expression levels of EMT markers,increasing α-SMA, vimentin, and MMP-9 expression and decreasingE-cadherin expression, with changes in cell morphology. TPA treatment induced EMT in a PKC-dependent manner. Moreover,the inhibition of aurora kinase A by siRNAs and inhibitors(reversine and VX-680) suppressed TPA-induced cell invasion,migration, and EMT in SW480 human colon cells. Inhibition ofaurora kinase A blocked TPA-induced vimentin and MMP-9 expression,and decreased E-cadherin expression. Furthermore, theknockdown of aurora kinase A decreased the transcriptionalactivity of NF-κB and AP-1 in PKC-stimulated SW480 cells. Thesefindings indicate that aurora kinase A induces migration andinvasion by inducing EMT in SW480 colon cancer cells. To thebest of our knowledge, this is the first study that showed aurorakinase A is a key molecule in PKC-induced metastasis in coloncancer cells.