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Bilateral inflammatory cysts of the jaw: report of an unusual case
Holla, Vidya A.,Chatra, Laxmikanth,Shenai, Prashanth,Rao, Prasanna Kumar,Veena, K.M.,Prabhu, Rachana Vishnudas Korean Academy of Oral and Maxillofacial Radiology 2012 Imaging Science in Dentistry Vol.42 No.2
Radicular cyst is the most common odontogenic cyst occurring in the jaws. The cyst is commonly found in relation to the maxillary anterior teeth in the third and fifth decade of life. Although multiple radicular cysts are not uncommon in the jaws, bilaterally symmetrical representation of these cysts is rare. Radiographs prior to extraction help in diagnosis of these cysts and thereby prevent further morbidities. We report a case of 16-year-old male patient who presented bilateral radicular cysts symmetrically in the mandible.
Bharath Holla,Sheshachala Karthik,Jitendriya Biswal,Biju Viswanath,Deepak Jayarajan,Rose Dawn Bharath,Ganesan Venkatasubramanian,Vivek Benegal 대한정신약물학회 2018 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.16 No.3
Objective: Baclofen is a promising treatment for alcohol use disorders (AUD), although its clinical response in humans is mixed. The present study aimed at investigating the impact of baclofen treatment on cue-induced brain activation pattern and its relationship with relapse outcomes. Methods: Twenty-three inpatients with AUD underwent a functional magnetic resonance imaging cue-reactivity task before beginning medication with baclofen and 2 weeks later. Twelve additional inpatients with AUD, who did not receive any anticraving medications, formed the control group. All subjects were prospectively followed up for 90 days post-discharge or until lapse to first alcohol use. Results: Whole-brain linear mixed effects analysis revealed a significant group-by-time interaction with greater activation of the bilateral dorsolateral pre-frontal cortex and right anterior cingulate cortex (ACC) following baclofen treatment in comparison with the control group. Further, cox regression analysis revealed that increased activation of ACC and deactivation of insular cortex (IC) was associated with longer time to first alcohol use only in the baclofen treatment group but not in the control group. Conclusion: This study provides preliminary evidence for the neural predictors of baclofen treatment response in AUD. Baclofen treatment in AUD was associated with changes in cue-reactivity at critical brain regions within the incentive- salience network. Importantly, baclofen treatment-related specific activation of regions involved in cognitive control (ACC) and deactivation of regions involved in reward anticipation (IC) prolonged the time to first alcohol drink
Speech induced task specific cranio-cervical tardive dystonia: An unusual phenomenology
Vikram Venkappayya Holla 대한파킨슨병및이상운동질환학회 2021 Journal Of Movement Disorders Vol.14 No.1
Dystonia is defined as sustained or intermittent muscle contractions causing abnormal, often repetitive, movements, postures, or both. Task-specific dystonia (TSD) encompasses a group of focal dystonias, affecting an isolated body part, predominantly laryngeal and hand muscles, and triggered by a specific and often skilled task. Frequently reported TSDs include laryngeal dystonia, writer’s cramp, musician’s dystonia, and occupational dystonia. Speech-induced dystonia often involves laryngeal and cranial muscles, with a speech-induced cervical TSD very rarely reported
Deep Brain Stimulation Battery Exhaustion during the COVID-19 Pandemic: Crisis within a Crisis
Vikram Venkappayya Holla,Koti Neeraja,Bharath Kumar Surisetti,Shweta Prasad,Nitish Kamble,Dwarakanath Srinivas,Ravi Yadav,Pramod Kumar Pal 대한파킨슨병및이상운동질환학회 2020 Journal Of Movement Disorders Vol.13 No.3
The novel coronavirus disease (COVID-19) pandemic and public health measures to control it have resulted in unique challenges in the management of patients with deep brain stimulation (DBS). We report our experience with the management of acute worsening of symptoms due to battery exhaustion in 3 patients with DBS.
Vikram V. Holla 대한파킨슨병및이상운동질환학회 2024 Journal Of Movement Disorders Vol.17 No.1
Isoniazid is an antitubercular drug that is an important part of the first-line treatment regimen for tuberculosis treatment and prophylaxis. Although hepatotoxicity is one of the common side effects of isoniazid, neurological complications such as encephalopathy, seizure, peripheral neuropathy, and occasional ataxia are not uncommon. Isoniazid-induced ataxia is often associated with bilateral dentate nucleus hyperintensity, with only a few reports of additional thalamic hyperintensity. We report a case of possible isoniazid toxicity-induced ataxia in a 23-year-old man in whom magnetic resonance imaging (MRI) of the brain showed bilateral thalamic hyperintensity along with the “face of the giant panda” sign.
Utility of Clinical Exome Sequencing in Dystonia: A Single-Center Study From India
Vikram Venkappayya Holla,Pramod Kumar Pal 대한파킨슨병및이상운동질환학회 2022 Journal Of Movement Disorders Vol.15 No.2
With the use of next-generation sequencing in clinical practice, several genetic etiologies of dystonia have been identified. This study aimed to ascertain the utility of clinical exome sequencing (CES) in dystonia and factors suggestive of a genetic etiology.
Bilateral inflammatory cysts of the jaw : report of an unusual case
Vidya A. Holla,Laxmikanth Chatra,Prashanth Shenai,Prasanna Kumar Rao,KM Veena,Rachana Vishnudas Prabhu 대한구강악안면방사선학회 2012 Imaging Science in Dentistry Vol.42 No.2
Radicular cyst is the most common odontogenic cyst occurring in the jaws. The cyst is commonly found in relation to the maxillary anterior teeth in the third and fifth decade of life. Although multiple radicular cysts are not uncommon in the jaws, bilaterally symmetrical representation of these cysts is rare. Radiographs prior to extraction help in diagnosis of these cysts and thereby prevent further morbidities. We report a case of 16-year-old male patient who presented bilateral radicular cysts symmetrically in the mandible.
Sialidosis type I without cherry red spot – Is there a genetic basis?
Koti Neeraja,Vikram Venkappayya Holla,Shweta Prasad,Bharath Kumar Surisetti,Kempaiah Rakesh,Nitish Kamble,Ravi Yadav,Pramod Kumar Pal 대한파킨슨병및이상운동질환학회 2021 Journal Of Movement Disorders Vol.14 No.1
Sialidosis is an inborn error of metabolism due to a defect in the NEU1 gene and manifests as two phenotypes: mild type I and severe type II. The cherry red spot (CRS) is a characteristic feature in both types of sialidosis; reports of sialidosis without a CRS are rare. We report two cases of genetically confirmed sialidosis type I with a typical presentation of progressive cortical myoclonus and ataxia but without the CRS. A previously reported homozygous pathogenic variant p.Arg294Cys was detected in the first case, and a novel homozygous pathogenic variant p.Arg305Pro was detected in the second case. Additionally, we reviewed the literature describing cases with similar mutations to find a genetic basis for the absence of a CRS. Milder mutation of both alleles detected in both patients may be the reason for the absence of a CRS.
Clinical and Imaging Profile of Patients with Joubert Syndrome
Bharath Kumar Surisetti,Vikram Venkappayya Holla,Shweta Prasad,Koti Neeraja,Nitish Kamble,Ravi Yadav,Pramod Kumar Pal 대한파킨슨병및이상운동질환학회 2021 Journal Of Movement Disorders Vol.14 No.3
Nine patients were included in the study. All patients had facial dysmorphism and ocular abnormalities, and 4 patients had dystonia. Ocular tilt reaction and alternate skew deviation (66%) were the most common ocular abnormalities. Horizontally aligned superior cerebellar peduncles were observed in all four patients with diffusion tensor imaging, with a lack of decussation in three. Exome sequencing performed in four patients revealed novel variants in the MKS1, CPLANE1, and PIBF1 genes.
Thavasimuthu Nisha Mol,Nitish Kamble,Vikram V. Holla,Rohan Mahale,Pramod Kumar Pal,Ravi Yadav 대한파킨슨병및이상운동질환학회 2021 Journal Of Movement Disorders Vol.14 No.2
ObjectiveaaThere is limited literature on the knowledge, attitude, and perceptions (KAP) of botulinum toxin (BoNT) treatmentamong patients and caregivers. The objective of this study was to assess the KAP in patients undergoing BoNT treatment for movementdisorders. MethodsaaOne hundred patients with movement disorders from National Institute of Mental Health and Neurosciences Hospitalin Bengaluru, South India, were recruited. The patients underwent demographic, clinical, and Patient Knowledge Questionnaireon Botulinum Toxin Use in Movement Disorders (PKQ-BMD)-based evaluations. ResultsaaThe mean age of patients at the time of presentation was 47.97 ± 14.19 years (range, 12–79). Of all the patients, 26 (28%)patients were anxious, and 86% of these patients were reassured after appropriate counseling. There were 83 (89%) patients whofound BoNT to be a costlier option. Education and previous Internet searches influenced positive performance in the “knowledge”domain and overall PKQ-BMD scores. The “number of injections” was also positively correlated with KAP performance. ConclusionaaThis study showed that knowledge and perceptions about BoNT treatment need to be further improved. Wideravailability of the Internet has provided a positive impact on patients’ and carers’ KAP. Internet-based information, higher educationalqualifications of the patients, and a higher number of BoNT injection sessions are the most important predictors of satisfactoryKAP related to BoNT injection treatment in patients with movement disorders