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Manganism without Parkinsonism: Isolated Unilateral Upper Limb Tremor in a Welder
Shweta Prasad,Uzma Shamim,Akanksha Minj,Mohammed Faruq,Pramod Kumar Pal 대한파킨슨병및이상운동질환학회 2019 Journal Of Movement Disorders Vol.12 No.2
Manganese neurotoxicity, or manganism, was first described by Couper et al. in 1837 [1] and presents as hypophonia, excessive salivation, limb tremor, muscle weakness and a bent posture while walking.
Shweta Prasad,Amitabh Bhattacharya,Lulup Kumar Sahoo,Dhruv Batra,Nitish Kamble,Ravi Yadav,Dwarakanath Srinivas,Pramod Kumar Pal 대한파킨슨병및이상운동질환학회 2021 Journal Of Movement Disorders Vol.14 No.1
There are very significant knowledge gaps and misconceptions regarding DBS among patients with PD and caregivers. Adequate and appropriate education is necessary to clarify these misconceptions to avoid the development of unrealistic expectations and poor satisfaction.
Levodopa-Associated Barking Vocalizations
Shweta Prasad,Pramod Kumar Pal 대한파킨슨병및이상운동질환학회 2021 Journal Of Movement Disorders Vol.14 No.2
Involuntary vocalizations include a wide spectrum of soundsassociated with physiological responses such as coughing orsneezing, emotional responses such as laughing or crying, andeven the utterance of words that have a specific intended meaning. 1 These are often associated with Tourette’s syndrome andother tic disorders.
Kinetic model for sorption of divalent heavy metal ions on low cost minerals
Murari Prasad,Aseem Chawla,Rishta Goswami,Shweta Ranshore,Ankita Kulshreshtha,Akhouri Sudhir Kumar Sinha 한국화학공학회 2016 Korean Journal of Chemical Engineering Vol.33 No.2
A mathematical model is proposed that could predict the kinetic parameters for adsorption of divalent heavy metal ions (lead, copper and zinc) onto low-cost adsorbents such as pyrophyllite and rock phosphate using experimental data. The experiments were conducted with the initial concentrations of metal ions ranging from 10mg/L to 100mg/L. The mathematical model is based on the application of the Redlich-Peterson isotherm to mass transfer across the film surrounding the adsorbent. The developed non-linear sorption kinetic (NSK) mathematical model was solved using numerical integration by the trapezoidal method in Microsoft Excel along with the SOLVER function to obtain the best simulated values of the Redlich-Peterson constants A, B, r, the order of reaction n, and the film transfer coefficient α. Dissolution followed by precipitation was found to be the most probable mechanism responsible for heavy metal ion uptake by rock phosphate, while for pyrophyllite physical adsorption was governing mechanism at low concentrations (<100mg/L). The values of parameters A, B, r and α lie in the ranges of 0.015-23.2, 0.00003-3.09, 0.072- 1, and 0.000057-52.8 [(L/mg)(n−1)/min], respectively, under different experimental conditions.
Conformal Quasi Hemi slant Riemannian submersions from cosymplectic manifolds
Rajendra Prasad,Shweta Singh 장전수학회 2023 Proceedings of the Jangjeon mathematical society Vol.26 No.4
Conformal Quasi Hemi slant Riemannian submersions from cosymplectic manifolds
Movement Disorders Associated With Radiotherapy and Surgical Procedures
Bharath Kumar Surisetti,Shweta Prasad,Pramod Kumar Pal 대한파킨슨병및이상운동질환학회 2023 Journal Of Movement Disorders Vol.16 No.1
Occasionally, movement disorders can occur following interventional procedures including but not limited to radiotherapy, dental procedures, and cardiac, cerebral and spinal surgeries. The majority of these disorders tend to be unexpected sequelae with variable phenomenology and latency, and they can often be far more disabling than the primary disease for which the procedure was performed. Owing to poor knowledge and awareness of the problem, delays in diagnosing the condition are common, as are misdiagnoses as functional movement disorders. This narrative review discusses the phenomenology, pathophysiology, and potential treatments of various movement disorders caused by interventional procedures such as radiotherapy and neurological and non-neurological surgeries and procedures.
The Non-Motor Symptom Profile of Progressive Supranuclear Palsy
Sudhakar Pushpa Chaithra,Shweta Prasad,Vikram Venkappayya Holla,Albert Stezin,Nitish Kamble,Ravi Yadav,Pramod Kumar Pal 대한파킨슨병및이상운동질환학회 2020 Journal Of Movement Disorders Vol.13 No.2
ObjectiveaaNon-motor symptoms (NMSs) significantly contribute to increased morbidity and poor quality of life in patients withparkinsonian disorders. This study aims to explore the profile of NMSs in patients with progressive supranuclear palsy (PSP) usingthe validated Non-Motor Symptom Scale (NMSS). MethodsaaSeventy-six patients with PSP were evaluated in this study. Motor symptoms and NMSs were evaluated using the PSPRating Scale (PSPRS), Unified Parkinson’s Disease Rating Scale-III, Montreal Cognitive Assessment, Hamilton Depression (HAMD)and Anxiety Rating Scales, Parkinson’s Disease Sleep Scale (PDSS) and NMSS. NMS severity and prevalence were also comparedbetween patients with PSP-Richardson syndrome (PSP-RS) and those with PSP-parkinsonism. ResultsaaAll subjects in this cohort reported at least 2 NMSs. The most prevalent NMSs in patients with PSP were in the domainsof sleep/fatigue, mood/cognition, and sexual function. The least prevalent NMSs were in the domains of cardiovascular includingfalls, and perceptual problems/hallucinations. Significant correlations were observed between the NMSS scores and HAM-D,PDSS, PSPRS scores and PSPRS sub-scores. The severity of NMSs was unrelated to the duration of illness. Patients with PSP-RSreported a higher severity of drooling, altered smell/taste, depression and altered interest in sex and a higher prevalence of sexualdysfunction. ConclusionaaNMSs are commonly observed in patients with PSP, and the domains of sleep, mood and sexual function aremost commonly affected. These symptoms contribute significantly to disease morbidity, and clinicians should pay adequate attentionto identifying and addressing these symptoms.
Clinical and Imaging Profile of Patients with Joubert Syndrome
Bharath Kumar Surisetti,Vikram Venkappayya Holla,Shweta Prasad,Koti Neeraja,Nitish Kamble,Ravi Yadav,Pramod Kumar Pal 대한파킨슨병및이상운동질환학회 2021 Journal Of Movement Disorders Vol.14 No.3
Nine patients were included in the study. All patients had facial dysmorphism and ocular abnormalities, and 4 patients had dystonia. Ocular tilt reaction and alternate skew deviation (66%) were the most common ocular abnormalities. Horizontally aligned superior cerebellar peduncles were observed in all four patients with diffusion tensor imaging, with a lack of decussation in three. Exome sequencing performed in four patients revealed novel variants in the MKS1, CPLANE1, and PIBF1 genes.
Sialidosis type I without cherry red spot – Is there a genetic basis?
Koti Neeraja,Vikram Venkappayya Holla,Shweta Prasad,Bharath Kumar Surisetti,Kempaiah Rakesh,Nitish Kamble,Ravi Yadav,Pramod Kumar Pal 대한파킨슨병및이상운동질환학회 2021 Journal Of Movement Disorders Vol.14 No.1
Sialidosis is an inborn error of metabolism due to a defect in the NEU1 gene and manifests as two phenotypes: mild type I and severe type II. The cherry red spot (CRS) is a characteristic feature in both types of sialidosis; reports of sialidosis without a CRS are rare. We report two cases of genetically confirmed sialidosis type I with a typical presentation of progressive cortical myoclonus and ataxia but without the CRS. A previously reported homozygous pathogenic variant p.Arg294Cys was detected in the first case, and a novel homozygous pathogenic variant p.Arg305Pro was detected in the second case. Additionally, we reviewed the literature describing cases with similar mutations to find a genetic basis for the absence of a CRS. Milder mutation of both alleles detected in both patients may be the reason for the absence of a CRS.
Deep Brain Stimulation Battery Exhaustion during the COVID-19 Pandemic: Crisis within a Crisis
Vikram Venkappayya Holla,Koti Neeraja,Bharath Kumar Surisetti,Shweta Prasad,Nitish Kamble,Dwarakanath Srinivas,Ravi Yadav,Pramod Kumar Pal 대한파킨슨병및이상운동질환학회 2020 Journal Of Movement Disorders Vol.13 No.3
The novel coronavirus disease (COVID-19) pandemic and public health measures to control it have resulted in unique challenges in the management of patients with deep brain stimulation (DBS). We report our experience with the management of acute worsening of symptoms due to battery exhaustion in 3 patients with DBS.