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- 저자 : Hailun Xie (검색결과 2 건)
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Hailun Xie,Yizhen Gong,Jiaan Kuang,Ling Yan,Guotian Ruan,Shuangyi Tang,Feng Gao,Jialiang Gan 대한암학회 2020 Cancer Research and Treatment Vol.52 No.3
Purpose This study aimed to establish whether computed tomography (CT)–determined sarcopenia is a useful imaging biomarker for postoperative outcome in elderly colorectal cancer (CRC) patients, and construct sarcopenia-based nomograms to predict individual outcomes after surgery. Materials and Methods CT imaging data of 298 elderly CRC patients who underwent surgery in 2012-2014 were retrospectively analyzed. Skeletal muscle mass was determined by CT, and sarcopenia was diagnosed based on the optimal cutoff value determined by X-tile program. The correlation between sarcopenia and risk of preoperative nutrition and postoperative complications was evaluated. A Cox proportional hazards model was used to determine survival predictors. Sarcopenia-based nomograms were developed based on multivariate analysis, and calibrated using concordance index and calibration curves. Results A total 132 patients (44.3%) had sarcopenia based on the optimum cutoff values (29.9 cm2/m2 for women and 49.5 cm2/m2 for men). Sarcopenia was an independent risk factor for preoperative nutrition (p < 0.001; odds ratio [OR], 3.405; 95% confidence interval [CI], 1.948 to 5.954) and postoperative complications (p=0.008; OR, 2.192; 95% CI, 1.231 to 3.903). Sarcopenia was an independent predictor for poor progression-free survival (p < 0.001; hazard ratio [HR], 2.175; 95% CI, 1.489 to 3.179) and overall survival (p < 0.001; HR, 2.524; 95% CI, 1.721 to 3.703). Based on multivariate analysis, we produced four nomograms that had better predictive performance. Conclusion CT-determined sarcopenia is a useful imaging biomarker for predicting preoperative nutritional risk, postoperative complications, and long-term outcomes in elderly CRC patients. The sarcopenia-based nomograms can provide a scientific basis for guiding therapeutic schedule and follow-up strategies.
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Yongtao Lin,Mingyue Zhao,Lin Bai,Hailun Li,Yong Xu,Xiang Li,Juan Xie,Yiyuan Zhang,Donghui Zheng 한국공업화학회 2021 Journal of Industrial and Engineering Chemistry Vol.97 No.-
Renal ischemia-reperfusion injury (RI/R) is one of the main causes of acute renal injury and a commonclinical disease with high morbidity and mortality. It is of great significance to deliver microRNAs(miRNAs) to cells and in vivo to realize gene regulation and treatment of related diseases. In this study, wereported that the nanocomplex FMN-17 could realize both therapeutic and functional monitoringsimultaneously in vivo and in vitro. The nanocomplex comprised a cationic cell-penetrating peptidenona-arginine, a targeting ligand folic acid, a caspase-3 responsive moiety, and a Cy imaging moiety. Thenanocomplex FMN-17 has been shown to deliver miR-17-5p efficiently and selectively into HK-2 cells andtissues. Treatment of HK-2 cells with the nanocomplex significantly increased the miR-17-5p level andinhibited apoptosis, as evident by reducing the expression of active caspase-3 and reactive oxygenspecies. Uptake of FMN-17 in vivo alleviated renal tissue injury by histological assessment. In summary,we designed and synthesized a new miRNA delivery system with high transfection efficiency, goodtherapeutic effect, and near-infrared imaging in renal ischemia/reperfusion injury.
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