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Yongtao Lin,Mingyue Zhao,Lin Bai,Hailun Li,Yong Xu,Xiang Li,Juan Xie,Yiyuan Zhang,Donghui Zheng 한국공업화학회 2021 Journal of Industrial and Engineering Chemistry Vol.97 No.-
Renal ischemia-reperfusion injury (RI/R) is one of the main causes of acute renal injury and a commonclinical disease with high morbidity and mortality. It is of great significance to deliver microRNAs(miRNAs) to cells and in vivo to realize gene regulation and treatment of related diseases. In this study, wereported that the nanocomplex FMN-17 could realize both therapeutic and functional monitoringsimultaneously in vivo and in vitro. The nanocomplex comprised a cationic cell-penetrating peptidenona-arginine, a targeting ligand folic acid, a caspase-3 responsive moiety, and a Cy imaging moiety. Thenanocomplex FMN-17 has been shown to deliver miR-17-5p efficiently and selectively into HK-2 cells andtissues. Treatment of HK-2 cells with the nanocomplex significantly increased the miR-17-5p level andinhibited apoptosis, as evident by reducing the expression of active caspase-3 and reactive oxygenspecies. Uptake of FMN-17 in vivo alleviated renal tissue injury by histological assessment. In summary,we designed and synthesized a new miRNA delivery system with high transfection efficiency, goodtherapeutic effect, and near-infrared imaging in renal ischemia/reperfusion injury.
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