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National Cancer Incidence for the Year 2002 in Korea
Hai-Rim Shin,Kyu-Won Jung,Young-Joo Won,Hyun-Joo Kong,Seon-Hee Yim,Joohon Sung,Sun-Won Seo,Ki-Young Kim,Sang-Yi Lee,In-Sik Kong,In Kyoung Hwang,Choong Won Lee,Ze-Hong Woo,Tae-Yong Lee,Jin-Su Choi,Cheo 대한암학회 2007 Cancer Research and Treatment Vol.39 No.4
Hai-Rim Shin,Yoon-Ok Ahn,Jong-Myon Bae,Myung-Hee Shin,Duk-Hee Lee,Choong-Won Lee,Heechoul Ohrr,Don-Hee Ahn,Jacques Ferlay,Dornald Maxwell Parkin,Dae-Kyu Oh,Jae-Gahb Park 대한암학회 2002 Cancer Research and Treatment Vol.34 No.6
Purpose: We estimated the incidence of cancer inKorea.Materials and Methods: The indicence of cancer wasestimated using national mortality data, and the incidencedata from four frontier regional cancer registries,including Kangwha, Seoul, Busan and Deagu. These fourregistries served a population about seventeen million,which is almost 38% of entire population in Korea.Results: The overall age-standardized incidence rates(ASR) were 287.0 and 163.1 per 100,000 for males andfemales, respectively. Among males, stomach cancer wasthe most frequent (ASR 69.6), followed by lung cancers,including bronchus cancer (ASR 54.5), liver cancer (ASR47.0) and colo-rectal cancer (ASR 25.2). The most frequentsites of cancer in females, by rank order, were stomach(ASR 26.8), breast (ASR 20.1), uterine cervix (ASR 18.0),colo-rectum (ASR 15.9), lung (ASR 13.0) and liver (ASR12.0).Conclusion: It is hoped that these results will providevaluable leads for cancer research and cancer control inKorea. (Cancer Res Treat. 2002;34:405-408)
HAI JOON LEE,ILL WON KIM,CHANG DO KIM,GWIY SANG CHUNG,JAE SHIN LEE,SUN HEE KANG 한국물리학회 2006 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.49 No.III
We have fabricated 99.0SnO2+0.5CoO+0.5ZnO (SCZ) varistor ceramics by using a solid-state reaction method and studied the influence of sintering temperature on the nonlinear electrical properties by measuring the impedance, the grain and the grain boundary resistance, the breakdown field, and the nonlinear coefficient as functions of the temperature, the electric field, and the frequency. The conduction behaviors of O0 ions (0.6 eV) was found to be dominated by reduction of Co00 Sn and Zn00 Sn defects (0.4 eV) with increasing sintering temperature. The breakdown field (EB, 800 900 V/cm) and the nonlinear coefficient (, 9.3) of the SCZ ceramics were stabilized above a sintering temperature of 1350 C.
( Hai Jin Kim ),( Jeong Han Kim ),( Sung Noh Hong ),( Soon Young Ko ),( Won Hyeok Choe ),( So Young Kwon ),( Chang Hong Lee ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.-
Background: It is well known that Non-alcoholic Fatty Liver Disease (NAFLD) patients have increased coronary heart disease (CHD) risk. On the other hand, CHD risk of fatty liver patients other than NAFLD has not been well estimated. The aim of this study is to compare CHD risk of NAFLD with alcohol related fatty liver individuals. Methods: Individuals who underwent voluntary general health examination at Konkuk university Health Care Center were recruited. We included into the study population patients who underwent abdominal imaging study and who were verified of the presence fatty liver (N=9,935). Then we sub-grouped the fatty liver patients into NAFLD and alcoholic fatty liver, according to the amount of alcohol intake (<140 g/week in male and <70 g/week in female) with imaging study results. The Framingham Risk Score (FRS) was used for evaluation of CHD risk at those patients. Results: Fatty liver was diagnosed in 4,039 of the 9,935 individuals (NAFLD 2,273 and alcoholic fatty liver 1,766). The 5,986 normal individuals constituted the control group. The mean FRS (-0.2 vs. 2.6, p<0.001) and mean estimated 10 year CHD risk (3.2% vs. 4.3%, p<0.001) higher at fatty liver than normal group. Among individuals with fatty liver, the mean FRS (2.8 vs. 2.4, p=0.004) and mean estimated 10 year CHD risk (4.5% vs. 4.0%, p<0.001) were higher in NAFLD group. After adjusted by age using ANCOVA, however, mean FRS (2.4 vs. 2.8, p<0.001) and mean estimated 10 year CHD risk (4.3 vs. 4.4, p<0.001) were higher in alcoholic fatty liver group. Conclusions: Fatty liver patients have higher CHD risk than normal population, as expected. In addition, our data suggest that higher CHD risk is anticipated in alcohol related fatty liver individuals than in NAFLD individuals.
( Hai Jin Kim ),( Jeong Han Kim ),( Won Hyeok Choe ),( So Young Kwon ),( Chang Hong Lee ) 대한간학회 2014 Clinical and Molecular Hepatology(대한간학회지) Vol.20 No.2
Background/Aims: A close relationship has been established between nonalcoholic fatty liver disease (NAFLD) and an elevated risk of coronary heart disease (CHD), but little is known about the association between alcoholic fatty liver disease (AFLD) and CHD risk. The aim of this study was to determine whether AFLD is associated with elevated CHD risk. Methods: We retrospectively enrolled 10,710 subjects out of 11,469 individuals who visited the Konkuk University Health Care Center for a routine health checkup in 2010. AFLD was diagnosed made when the usual amount of alcohol consumption exceeded 210 g/week in males and 140 g/week in females for the previous 2 years and when hepatic steatosis was detected by liver ultrasonography. The 10-year risk for CHD was estimated using the Framingham Risk Score. Results: Hepatic steatosis was diagnosed in 4,142 of the 10,710 individuals (38.7%); the remainder (i.e., n=6,568) became the control group. The 4,142 individuals with hepatic steatosis were divided into two groups: NAFLD (n=2,953) and AFLD (n=1,189). The risk of CHD was higher in AFLD (6.72±0.12) than in the control group (5.50±0.04, P<0.001), and comparable to that in NAFLD (7.32±0.07, P=0.02). Conclusions: Individuals with AFLD have an elevated 10-year risk of CHD that is comparable to those with NAFLD. Therefore, AFLD should be considered a significant risk for future CHD, and preventive measures should be considered earlier. (Clin Mol Hepatol 2014;20:154-161)
Lee, Younghyun,Kim, Yang Jee,Choi, Young Joo,Lee, Joong Won,Lee, Sunyeong,Cho, Yoon Hee,Chung, Hai Won Informa Healthcare 2015 International Journal of Radiation Biology Vol.91 No.2
<P><I>Purpose</I>: We investigated the association between occupational radiation exposure and DNA methylation changes in nuclear power plant workers. We also evaluated whether radiation- induced DNA methylation alterations are associated with chromosome aberrations.</P><P><I>Materials and methods</I>: The study population included 170 radiation-exposed workers and 30 controls. We measured global, long interspersed nuclear element-1 (LINE-1), and satellite 2 methylation levels in blood leukocyte DNA. The analysis of chromosome aberrations was performed on peripheral lymphocytes.</P><P><I>Results</I>: Global DNA methylation levels were lower in radiation-exposed workers than in controls. The methylation levels were negatively associated with the recent 1.5-year radiation dose in a multiple linear regression model (β = − 0.0088, <I>p</I> ≤ 0.001); the levels increased proportionally with the total cumulative dose in radiation-exposed workers. LINE-1 methylation levels were higher in radiation-exposed workers than in controls and were significantly associated with the total cumulative radiation dose in a multiple linear regression model (β = − 0.031, <I>p</I> = 0.035). Global DNA methylation levels were also correlated with chromosome aberrations among workers. Workers with low global methylation levels had a higher frequency of chromosome aberrations than did subjects with high global methylation levels.</P><P><I>Conclusion</I>: Occupational exposure to low-dose radiation could affect DNA methylation levels, and the radiation-induced DNA methylation alterations may be associated with chromosome aberrations.</P>
Factors Affecting the Rat of Release of 5- Fluorouracil from Ethylene - Vinyl Acetate Matrices
Lee,Hai Bang,Oh,Seaung Youl,Chung,Hee Won,Cho,Sun Hang 한국약제학회 1994 Journal of Pharmaceutical Investigation Vol.24 No.3
We have studied the effect of loading amount and particle size on the rate of release of 5-fluorouracil (5-FU) from ethylene-vinyl acetate (EVA_c) matrix. Release rate increased as the loading amount and particle size increase. We also studied the effect of additives (lactose and algin) on the rate of release of 5-FU. Both algin and lactose promoted the rate of release. The ability to increase the rate is in the order of algin>lactose>5-FU. Scanning electron microscope study clearly shows that large cavities and cracks are created. The results imply that, by the proper combinations of the amount of the additive, EVA_c and drug, the rate of drug release can be modulated over a wide range of values.