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RISS 인기검색어
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- 저자 : Gul Karima (검색결과 2 건)
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Stem Cell Oriented Exosomes Regulate Cell Proliferation in Hepatoma Carcinoma
Gul Karima,신규순,정재민,최동호,황경균,홍종욱 한국생물공학회 2023 Biotechnology and Bioprocess Engineering Vol.28 No.2
Reprogrammed hepatic stem cells can generate a variety of extracellular vesicular particles including exosomes with similar therapeutic potential. However, their functional application in cancer therapy is restricted due to a poor understanding of their physical properties, antiproliferative effects, and the underlying mechanism. Here, we explore reprogrammed stem cells that can release vesicular particles with physical properties of exosomes that can exert anti-proliferative effects by regulating cell proliferationrelated genes. We obtain vesicular particles with properties of exosomes expressing CD81 and CD63 with the size distribution peak observed at 155 nm. We analyze that as compared to non-treated conditions, vesicular particles have reduced cell proliferation of Hep G2 by 93.6% after 72 h. Furthermore, we also identify that B-cell lymphoma 2 has been reduced by 89.64% and activation of caspase- 3 has occurred in treated conditions via the mitochondrial pathway. Therefore, our results may highlight the potential of exosomes from hepatic stem cells to play a vital role in treating liver pathologies.
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A Simple Paper-Based α-Amylase Separating System for Potential Application in Biological Sciences
형수진,Gul Karima,신규순,김광식,홍종욱 한국바이오칩학회 2021 BioChip Journal Vol.15 No.3
The salivary glands are closely associated with stress conditions and the neuroendocrine system. The concentrations of these salivary biomarkers fluctuate with a person’s disease status. Until now, salivary diagnostics have been promising; however, the analytical tools for detecting salivary biomarkers have remained burdensome due to the lack of user-friendly and costeff ective equipment. In this study, we used a microfluidic starch-coated paper-based chip to isolate α-amylase from human saliva. The concentration of α-amylase on the head and tail sections of the paper-based chip was compared in the presence or absence of starch. We found that α-amylase was highly concentrated only in the head section of the starch-coated paperbased chip through Western blotting (WB) and enzyme-linked immunosorbent assay (ELISA). We expect our designed paper-based chip will aid in α-amylase detection technologies using saliva and small amounts of other biofluids including blood, tears, pancreatic juice, and urine.
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