Research on Optimal Design for Water Supply and Energy Conservation in High-rise Office Buildings

Hou Gang,Li Bing 보안공학연구지원센터 2016 International Journal of Smart Home Vol.10 No.9

The energy conservation in high-rise office buildings is a key project of building energy conservation work in China. Based on the actual need of projects and with the water environment intelligent monitoring system of photovoltaic power generation as the core, this paper conducts the intelligent and informatization management to the water supply and drainage of high-rise office buildings. Based on the data specification of water supply and drainage design of sanitary ware in China, square-root method is used to design the traffic system, and the rainwater comprehensive utilization system is introduced by referring the advanced experience in China. With shaft power and efficiency index, the superiority of double-pump parallel frequency conversion in the water tank - pump frequency conversion water supply in high-rise office buildings, which provides reference and data base for the subsequent engineering practice and has certain engineering application value.

Intelligent Optimization of Solar Air Heating System in Large Scale Construction of and its Application

Hou Gang,Li Bing 보안공학연구지원센터 2016 International Journal of Smart Home Vol.10 No.8

The monomer thermal performance of solar air collector is the bottleneck problem of the design application of practical engineering. By combining the experimental and theoretical researches, this paper uses the heating load and thermal efficiency of the optimization module at different flow rates, and puts forward the efficiency normalization treatment method; analyzes the heat transfer intensity, heating capacity, thermal efficiency and indoor heating effect of the module under different operation modes; with the microprocessor as the core, sets up the intelligent control system of solar air heating with multiple sensor information fusion; adjust the running state of fan and heating units according to the changes of indoor and outdoor environment in real time. The practical application shows that the intelligent control system can ensure a comfortable indoor environment and improve the thermal efficiency of the system.

Simulation and Energy Analysis of Thermal Environment of Unassisted Passive Solar House

Hou Gang,Li Bing 보안공학연구지원센터 2016 International Journal of Smart Home Vol.10 No.2

The greenhouse effect it the most basic work principle of the passive solar house The passive solar house provide indoor heating relying on natural circulation, without any other mechanical power, with the excess heat stored in the walls, ceilings and ground hot body to radiate heat into the room at night, to maintain a certain temperature. It takes in, keeps, stores and distributes solar thermal energy by reasonable arrangement of building orientation and surrounding environment, smart manipulation of the inner and outer space and the proper selection of the building materials, structure and construction, so as to solve the problem of building heating. The heat collection and storage of the passive solar house mainly uses the building envelop walls or windows or the simple tablet device as a heat collector, which can be freely controlled by people, without the complex mechanical equipment and complex pipe ventilation system. The test takes a residential building as example for energy consumption simulation and from the results; we can obtain the temperature distribution in each room and the distribution of the annual heating and coldness load. Study the effect on the room temperature and reducing heating energy consumption by the different ways of thermal insulation.

Ginsenoside Rh2 Ameliorates Doxorubicin-Induced Senescence Bystander Effect in Breast Carcinoma Cell MDA-MB-231 and Normal Epithelial Cell MCF-10A

Hou, Jin-Gang,Jeon, Byeong-Min,Yun, Yee-Jin,Cui, Chang-Hao,Kim, Sun-Chang MDPI 2019 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.20 No.5

<P>The anthracycline antibiotic doxorubicin is commonly used antineoplastic drug in breast cancer treatment. Like most chemotherapy, doxorubicin does not selectively target tumorigenic cells with high proliferation rate and often causes serve side effects. In the present study, we demonstrated the cellular senescence and senescence associated secretory phenotype (SASP) of both breast tumor cell MDA-MB-231 and normal epithelial cell MCF-10A induced by clinical dose of doxorubicin (100 nM). Senescence was confirmed by flattened morphology, increased level of beta galactose, accumulating contents of lysosome and mitochondrial, and elevated expression of p16 and p21 proteins. Similarly, SASP was identified by highly secreted proteins IL-6, IL-8, GRO, GM-CSF, MCP-1, and MMP1 by antibody array assay. Reciprocal experiments, determined by cell proliferation and apoptosis assays and cell migration and cell invasion, indicated that SASP of MDA-MB-231 cell induces growth arrest of MCF-10A, whereas SASP of MCF-10A significantly stimulates the proliferation of MDA-MB-231. Interestingly, SASP from both cells powerfully promotes the cell migration and cell invasion of MDA-MB-231 cells. Treatment with the natural product ginsenoside Rh2 does not prevent cellular senescence or exert senolytic. However, SASP from senescent cells treated with Rh2 greatly attenuated the above-mentioned bystander effect. Altogether, Rh2 is a potential candidate to ameliorate this unwanted chemotherapy-induced senescence bystander effect. </P>

Study on Ginsenoside Rh1Derivatives and its Anti-tumor Bioactivity

Jing-Gang Hou,Lei Liu,Mi-Ra Lee,Zheng Li,Chang-Jin Oh,Jun-Hyuck Choi,Jung-Hee Cho,Byung-Chan Kim,Ran Kim,Eun-Kyoung Mo,Chang-Keun Sung 고려인삼학회 2011 고려인삼학회 학술대회 Vol.2011 No.4

MiR-99a Inhibits Cell Proliferation and Tumorigenesis through Targeting mTOR in Human Anaplastic Thyroid Cancer

Huang, Hou-Gang,Luo, Xi,Wu, Shuai,Jian, Bin Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.12

MicroRNAs (miRNAs) are emerging as critical regulators in carcinogenesis and tumor progression. Recently, miR-99a has been reported as a tumor suppressor gene in various human cancers, but its functions in the context of anaplastic thyroid cancer (ATC) remain unknown. In this study, we reported that miR-99a was commonly downregulated in ATC tissue specimens and cell lines with important functional consequences. Overexpression of miR-99a not only dramatically reduced ATC cell viability by inducing cell apoptosis and accumulation of cells at G1 phase, but also inhibited tumorigenicity in vivo. We then screened and identified a novel miR-99a target, mammalian target of rapamycin (mTOR), and it was further confirmed by luciferase assay. Up-regulation of miR-99a would markedly reduce the expression of mTOR and its downstream phosphorylated proteins (p-4E-BP1 and p-S6K1). Similar to restoring miR-99a expression, mTOR down-regulation suppressed cell viability and increased cell apoptosis, whereas restoration of mTOR expression significantly reversed the miR-99a antitumor activity and the inhibition of mTOR/p-4E-BP1/p-S6K1 signal pathway profile. In clinical specimens and cell lines, mTOR was commonly overexpressed and its protein levels were statistically inversely correlated with miR-99a expression. Taken together, our results demonstrated for the first time that miR-99a functions as a tumor suppressor and plays an important role in inhibiting the tumorigenesis through targeting the mTOR/p-4E-BP1/p-S6K1 pathway in ATC cells. Given these, miR-99a may serve as a novel prognostic/diagnostic and therapeutic target for treating ATC.

Electricity Effectively Utilization by Integrating Microbial Fuel Cells with Microbial Immobilization Technology for Denitrification

Lian-gang Hou,Qin-zheng Yang,Jun Li 한국생물공학회 2020 Biotechnology and Bioprocess Engineering Vol.25 No.3

We report a novel strategy of integrating microbial fuel cell (MFC) with microbial immobilization technology (MIT) in a sequencing batch reactor (SBR) to test the performance of nitrate removal for the first time. Results showed that MFC could enhance nitrate removal in the novel integrated system, especially for wastewater with low carbon-to-nitrogen ratios, and the nitrate removal efficiency reached 91.35% in the lab-scale integrated system, including 12.25% nitrate consumption by MFC in one typical cycle. The anode of MFC recovered energy in the form of electricity, floating cathode of MFC prevented the loss of immobilized denitrifying bacteria particles and degraded a portion of nitrate, and the maximum voltage production of MFC was 0.246 V. The novel integrated system in this paper showed excellent nitrate removal performance and it will be a highly potential novel setup for efficient nitrate removal of wastewater treatment.

Evaluating fire resistance of prestressed concrete bridge girders

Gang Zhang,Venkatesh Kodur,Wei Hou,Shuanhai He 국제구조공학회 2017 Structural Engineering and Mechanics, An Int'l Jou Vol.62 No.6

This paper presents an approach for evaluating performance of prestressed concrete (PC) bridge girders exposed to fire. A finite element based numerical model for tracing the response of fire exposed T girders is developed in ANSYS. The analysis is carried out in three stages, namely, fire temperature calculation, cross sectional temperature evaluation, and then strength, deformation and effective prestress analysis on girders exposed to elevated temperatures. The applicability of the computer program in tracing the response of PC bridge girders from the initial preloading stage to failure stage, due to combined effects of fire and structure loading, is demonstrated through a case study, and validated by test data of a scaled PC box girder under ISO834 fire condition. Results from the case study show that fire severity has a significant influence on the fire resistance of PC T girders and hydrocarbon fire is most dangerous for the girder. The prestress loss caused by elevated temperature is about 10% under hydrocarbon fire till the girder failure, which can lead to the increase in deflection of the PC girder. The rate of deflection failure criterion is suggested to determine the failure of PC T girder under fire.

A numerical method for evaluating fire performance of prestressed concrete T bridge girders

Gang Zhang,Venkatesh Kodur,Chaojie Song,Wei Hou,Shuanhai He 사단법인 한국계산역학회 2020 Computers and Concrete, An International Journal Vol.25 No.6

This paper presents a numerical method for evaluating fire performance of prestressed concrete (PC) T shaped bridge girders under combined effect of structural loading and hydrocarbon fire exposure conditions. A numerical model, developed using the computer program ANSYS, is employed to investigate fire response of PC T shaped bridge girders by taking into consideration structural inherent parameters, namely; arrangement of prestressing strands with in the girder section, thickness of concrete cover over prestressing strands, effective degree of prestress and content of prestressing strands. Then, a sequential thermo-mechanical analysis is performed to predict cross sectional temperature followed by mechanical response of T shaped bridge girders. The validity of the numerical model is established by comparing temperatures, deflections and failure time generated from fire tests. Through numerical studies, it is shown that thickness of concrete cover and arrangement of prestressing strands in girder section have significant influence on the fire resistance of PC T shaped bridge girders. Increase in effective degree of prestress in strands with triangular shaped layout and content in prestressing strands can slow down the progression of deflections in PC T shaped bridge girder towards the final stages of fire exposure, to thereby preventing sudden collapse of the girder. Rate of deflection based failure criterion governs failure in PC T shaped bridge girders under most hydrocarbon fire exposure conditions. Structural inherent parameters incorporated into sectional configuration can significantly enhance fire resistance of PC bridge girders; thus mitigating fire induced collapse of these bridge girders.

Workspace analysis of 3-CPS parallel micro-manipulator for mirror active adjusting platform

Gang Cheng,Bing-jing Qiu,De-hua Yang,Hou-guang Liu 대한기계학회 2013 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.27 No.12

In order to adjust telescope mirrors with high precision, a 3 cylindrical-prismatic-spherical (CPS) parallel micro-manipulator with 6 degrees-of-freedom (DOF) and partial decoupling is proposed. Structure characteristics of the micro-manipulator were analyzed and the kinematic equations were derived based on Euler method. To avoid tedious derivation, Jacobian matrix with screw theory representing the input and output relation of micro-manipulator is established by using velocity influence coefficient method. Combining topological structure characteristics of the 3-CPS parallel micro-manipulator, the solving procedures of workspace are obtained. Moreover, the position workspace with a given orientation and the orientation workspace with a given translation position are constructed by numerical simulations. The workspace range is chosen as the optimization goal of structure parameters, and the circumcircle radius ratio of base and moving platform and the lengths of each sub-link are optimized. The maximum condition number and the minimum singular value are chosen as the precision indexes to analyze the precision performance of the workspace. Then, the properties of the position workspaces with various orientations and the orientation workspaces with various positions are simulated numerically, and the simulation results prove that the 3-CPS parallel micro-manipulator has an ability to achieve high precision operations. This research provides a workspace modeling and optimization method for the practical application in telescope mirror adjustment or other fields requiring high precision.