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Fourati, Amine,Ghorbel, Iyadh,Karra, Amir,Elleuch, Mohamed Habib,Ennouri, Khalil Korean Society of Plastic and Reconstructive Surge 2019 Archives of Plastic Surgery Vol.46 No.2
Forearm fractures are common injuries in childhood. Median nerve entrapment is a rare complication of forearm fractures, but several cases have been reported in the literature. This case report discusses the diagnosis and management of median nerve entrapment in a 13-year-old male who presented acutely with a both-bone forearm fracture and numbness in the median nerve distribution. Following the delayed diagnosis, surgical exploration revealed complete nerve entrapment and a nerve graft was performed.
Amine Fourati,Iyadh Ghorbel,Amir Karra,Mohamed Habib Elleuch,Khalil Ennouri 대한성형외과학회 2019 Archives of Plastic Surgery Vol.46 No.2
Forearm fractures are common injuries in childhood. Median nerve entrapment is a rare complication of forearm fractures, but several cases have been reported in the literature. This case report discusses the diagnosis and management of median nerve entrapment in a 13-yearold male who presented acutely with a both-bone forearm fracture and numbness in the median nerve distribution. Following the delayed diagnosis, surgical exploration revealed complete nerve entrapment and a nerve graft was performed.
Adjuvant-dependent innate and adaptive immune signatures of risk of SIV<sub>mac251</sub> acquisition
Vaccari, Monica,Gordon, Shari N,Fourati, Slim,Schifanella, Luca,Liyanage, Namal P M,Cameron, Mark,Keele, Brandon F,Shen, Xiaoying,Tomaras, Georgia D,Billings, Erik,Rao, Mangala,Chung, Amy W,Dowell, Ka Nature Publishing Group 2016 Nature medicine Vol.22 No.7
<P>A recombinant vaccine containing Aventis Pasteur's canarypox vector (ALVAC)-HIV and gp120 alum. decreased the risk of HIV acquisition in the RV144 vaccine trial. The substitution, of alum with the more immunogenic MF59 adjuvant is under consideration for the next efficacy human trial. We found here that an ALVAC-simian immunodeficiency virus (SIV) and gp120 alum (ALVAC-SIV + gp120) equivalent vaccine, but not an ALVAC-SIV + gp120 MF59 vaccine, was efficacious in delaying the onset of SIVmac251 in rhesus macaques, despite the higher immunogenicity of the latter adjuvant. Vaccine efficacy was associated with alum-induced, but not with MF59-induced, envelope (Env)-dependent mucosal innate lymphoid cells (ILCs) that produce interleukin (IL)-17, as well as with mucosal IgG to the gp120 variable region 2 (V2) and the expression of 12 genes, ten of which are part of the RAS pathway. The association between RAS activation and vaccine efficacy was also observed in an independent efficacious SIV-vaccine approach. Whether RAS activation, mucosal ILCs and antibodies to V2 are also important hallmarks of HIV-vaccine efficacy in humans will require further studies.</P>