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Fawzi J. Abuhijla, MD, MSc,Abdelatif M. Al-Mousa,Issa A. Mohamad,Ramiz A. Abuhijlih,Sondos A. Al-Khatib,Anoud Z. Alnsour,Wafa A. Asha,Shada W. Ramahi,Ali A. Hosni,Fawzi J. Abuhijla 대한방사선종양학회 2019 Radiation Oncology Journal Vol.37 No.1
Purpose: The quality assurance (QA) chart rounds are multidisciplinary meetings to review radiation therapy (RT) treatment plans. This study focus on describing the changes in RT management based on QA round reviews in a single institution. Materials and Methods: After 9 full years of implementation, a retrospective review of all patients whose charts passed through departmental QA chart rounds from 2007 to 2015. The reviewed cases were presented for RT plan review; subcategorized based on decision in QA rounds into: approved, minor modifications or major modifications. Major modification defined as any substantial change which required patient re-simulation or re-planning prior to commencement of RT. Minor modification included treatment plan changes which didn’t necessarily require RT re-planning. Results: Overall 7,149 RT treatment plans for different anatomical sites were reviewed at QA rounds. From these treatment plans, 6,654 (93%) were approved, 144 (2%) required minor modifications, while 351 (5%) required major modifications. Major modification included changes in: selected RT dose (96/351, 27%), target volume definition (127/351, 36%), organs-at-risk contouring (10/351, 3%), dose volume objectives/constraints criteria (90/351, 26%), and intent of treatment (28/351, 8%). The RT plans which required major modification according to the tumor subtype were as follows: head and neck (104/904, 12%), thoracic (12/199, 6%), gastrointestinal (33/687,5%), skin (5/106, 5%), genitourinary (16/359, 4%), breast (104/2387, 4%), central nervous system (36/846, 4%), sarcoma (11/277, 4%), pediatric (7/251, 3%), lymphoma (10/423, 2%), gynecological tumors (2/359, 1%), and others (11/351, 3%). Conclusion: Multi-disciplinary standardized QA chart rounds provide a comprehensive and an influential method on RT plans and/ or treatment decisions.
Fawzy, Amal,Mohamed, Mohamed R,Ali, Mohamed AM,El-Magied, Mohamed H Abd,Helal, Amany M Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.1
Background: Ovarian cancer remains a major worldwide health care issue due to the lack of satisfactory diagnostic methods for early detection of the disease. Prior studies on the role of serum cancer antigen 125 (CA125) and human epididymis protein 4 (HE4) in detecting ovarian cancer presented conflicting results. New tools to improve the accuracy of identifying malignancy are urgently needed. We here aimed to evaluate the diagnostic utility of tissue CA125 and HE4 gene expression in comparison to serum CA125 and HE4 in discriminating benign from malignant pelvic masses. Materials and Methods: One-hundred Egyptian women were enrolled in this study, including 60 epithelial ovarian cancer (EOC) patients and 20 benign ovarian tumor patients, as well as 20 apparently healthy women. Preoperative serum levels of CA125 and HE4 were measured by immunoassays. Tissue expression levels of genes encoding CA125 and HE4 were determined by quantitative real time polymerase chain reaction (qRT-PCR). The diagnostic performance of CA125 and HE4, measured either as mRNA or protein levels, was evaluated by receiver operating characteristic (ROC) curves. Results: The serum CA125+HE4 combination and serum HE4, with area under the curve (AUC) values of 0.935 and 0.932, respectively, performed significantly better than serum CA125 (AUC=0.592; P<0.001). Tissue CA125 and HE4 (AUC=1) performed significantly better than serum CA125 (P<0.001), serum HE4 (P=0.016) and the serum CA125+HE4 combination (P=0.018). Conclusions: Measurement of tissue CA125 and HE4 gene expression not only improves discriminatory performance, but also broadens the range of differential diagnostic possibilities in distinguishing EOC from benign ovarian tumors.
Electroanatomical Mapping of the Urinary Bladder
Fawzy Farag,Martin Koens,Marij Tijssen,Sytse de Jong,Timon Fabius,Johnny Tromp,Hendrikje van Breda,Joep Smeets,Wout Feitz,John Heesakkers 대한배뇨장애요실금학회 2016 International Neurourology Journal Vol.20 No.2
A noncontact mapping system (EnSite) was used for electroanatomical mapping of the bladder simultaneously with pressure flow study in three women with lower urinary tract symptoms. We selected the periods of obvious detrusor activity. Data were processed to remove baseline drift, and an envelope of electrovesicography (EVG) data was created. The correlation coefficient for the correlation between between the EVG envelope and the detrusor pressure (Pdet) was calculated. Bladder geometry was successfully created in all 3 patients. Simultaneous recording of EVG and pressure flow data was successful in 1 patient. Scatter plots were made of the highest correlation coefficient, showing a positive correlation between the Pdet and the envelope, and negative correlation between abdominal pressure (Pabd) and the envelope. Minimal electrical activity could be observed. Significant weak to moderate correlation coefficients were found for the correlations between Pdet and EVG and between Pabd and EVG.
ON IMPULSIVE SYMMETRIC $Psi$-CAPUTO FRACTIONAL VOLTERRA-FREDHOLM INTEGRO-DIFFERENTIAL EQUATIONS
Fawzi Muttar Ismaael 경남대학교 기초과학연구소 2023 Nonlinear Functional Analysis and Applications Vol.28 No.3
We study the appropriate conditions for the findings of uniqueness and existence for a group of boundary value problems for impulsive $\Psi$-Caputo fractional nonlinear Volterra-Fredholm integro-differential equations (V-FIDEs) with symmetric boundary non-instantaneous conditions in this paper. The findings are based on the fixed point theorem of Krasnoselskii and the Banach contraction principle. Finally, the application is provided to validate our primary findings.
Life-Cycle Theory of Corporate Dividend Policy in Jordan
Fawzi A,AL SAWALQA 한국유통과학회 2021 The Journal of Asian Finance, Economics and Busine Vol.8 No.6
The study examines the effect of book value per share, retained earnings per share, asset turnover ratio, and age on dividend per share of non-financial Jordanian listed companies for the period from 2015 to 2019. The research hypotheses were formulated and evaluated based on the related dividend policy theories, in addition to prior empirical findings. Based on cross-section time-series data, a panel data model with 110-firm-year observations was developed. Both Random Effect Model (REM) and REM with Robust Standard Errors were employed to test the study hypotheses. Consistent with the life-cycle theory argument of dividend policy, the results of REM with Robust Standard Errors show that book value per share and retained earnings per share have a positive and significant relationship with dividend per share, while the relationship between asset turnover ratio and dividend per share is insignificant. With respect to the firm age, the results show an insignificant relationship with dividend per share. The findings of the current study show that both assets and stockholders’ equity of balance sheet are critical items in explaining the dividend policy of Jordanian non-financial firms. Thus, policy-makers, investors, financial analysts, and researchers are invited to employ and consider the current study model in any possible relevant contexts.
Fawzy, Mariam M,Wahid, Ahmed,Nazmy, Maiiada H,Hashem, Mohamed,Waked, Imam,Abdelwahab, Sayed F Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.4
Background: HCV is a major global health problem. IL-27 is a member of the IL-6/IL-12 cytokine family with a broad range of anti-inflammatory properties. Recent studies highlighted the effect of a SNP in the IL-27 promoter region on modulating the progression of infectious diseases and individual responses to therapy. Aim of the work: The present study investigated the potential role of (-964 A/G) SNP in the promoter region of IL-27p28 gene (alleles rs153109) on the outcome of HCV infection among genotype 4a infected patients. Materials and Methods: HCV genotyping confirmed that all of the HCV-infected patients had genotype 4a infection. Genomic DNA was extracted from 111 patients with chronic HCV infection, 42 spontaneous resolvers (SR) and 16 healthy controls. IL- 27p28.rs153109 genotyping was assessed using PCR-RFLP then confirmed by DNA sequencing. Results: The frequency of IL-27-p28.rs153109AA, AG, and GG genotypes among chronically infected subjects were 74.8 %, 25.2%, and 0% while among the SR, they were 57.1%, 35.7%, and 7.14%, respectively. Our data show the unique presence of G/G genotype in the SR group (3 patients; 7.14%). Moreover, the "G" allele frequencies among chronic and resolved subjects were 12.6% and 25.0%, respectively (p=0.0136). Importantly, subjects with the GG genotype were more likely to clear their HCV infection than those with the AA genotype (p=0.0118). Conclusions: HCV genotype 4a subjects with the IL-27-p28.rs153109 A/G and G/G genotype were more likely to clear their HCV infection. Therefore, we propose IL- 27p28.rs153109SNPas a genetic biomarker for predicting HCV infection outcome.
Fawzi Muttar Ismaael 경남대학교 기초과학연구소 2024 Nonlinear Functional Analysis and Applications Vol.29 No.1
In this paper, we investigate the suitable conditions for the existence results for a class of $\Im$-Hilfer fractional nonlinear Fredholm-Volterra models with new conditions. The findings are based on Banach contraction principle and Schauder's fixed point theorem. Also, the generalized Hyers-Ulam stability and generalized Hyers-Ulam-Rassias stability for solutions of the given problem are provided.
Attaby, Fawzy A.,Elneairy, M.A.A.,Elsayed, M.S. The Pharmaceutical Society of Korea 1999 Archives of Pharmacal Research Vol.22 No.2
The reaction of thiocyanoacetamide (1) with ${\alpha},{\beta}$-unsaturated ketones 2a,b resulted in the formation of the corresponding newly synthesized 1(H)-pyridinethione derivatives 3a,b. Compounds 3a,b were used as synthons for the preparation of 2-S-alkyl-, 2-S-acetamidopyridine, thieno[2,3-b]pyridine and pyrazolo[3,4-b]pyridine derivatives via a wide range of reactions with different reagents. The antimicrobial activity of some of the newly synthesized compounds was tested. Compounds 3a, 11a, 15a, and 19a,b were found to be the most active ones.
Attaby, Fawzy-A.,Eldin, Sanaa-M. The Pharmaceutical Society of Korea 1990 Archives of Pharmacal Research Vol.13 No.3
It has been found that $\alpha, \beta$-unsaturated nitrile derivatives 1-3 reached with S- methylisothiourea to give the prpone derivatives 4-6 respectively. Cyclisation of 4-6 using ethanolic hydrochloric acid afforded the pyridine derivatives 7-9 in good yields. On the other hand, the reactions of hydrazine hydrate and of phenylhydrazine with each of 7-9 gave the corresponding pyrazolopyridine derivatives 10-15. The structures of the newly synthesised derivatives were assigned on the basis of elemental analyses, IR and $^1H$-NMR spectral data studies.
Attaby, Fawzy A.,Zaki, Mayssoune Y.,Abdelhamid, Abdou O.,Ramadan, Nazmy A. The Pharmaceutical Society of Korea 1990 Archives of Pharmacal Research Vol.13 No.4
2-Bromo (2'-benzofury)gloxal-2-aryhydrazones I reacted with nucleophiles displacing the bromide. Treatment of I with active methylene compounds yield the pyrazole derivatives VIII-XI. Compounds XII-XIV reacted with hydrazine to give pyrazolo (3, 4-dipyridazine derivative XIV-XIV. The structures of the products were assigned and confirmed on the basis of their elemental analysis and spectral data.